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Consensus on Hearing Aid Candidature and Fitting for Mild Hearing Loss, With and Without Tinnitus: Delphi Review (2015)
Journal Article
Sereda, M., Hoare, D. J., Nicholson, R., Smith, S., & Hall, D. A. (2015). Consensus on Hearing Aid Candidature and Fitting for Mild Hearing Loss, With and Without Tinnitus: Delphi Review. Ear and Hearing, 36(4), 417-429. https://doi.org/10.1097/AUD.0000000000000140

Objectives: In many countries including the United Kingdom, hearing aids are a first line of audiologic intervention for many people with tinnitus and aidable hearing loss. Nevertheless, there is a lack of high quality evidence to support that the... Read More about Consensus on Hearing Aid Candidature and Fitting for Mild Hearing Loss, With and Without Tinnitus: Delphi Review.

Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer (2015)
Journal Article
Zamberlan, F., Lesbats, C., Rogers, N. J., Krupa, J. L., Pavlovskaya, G. E., Thomas, N. R., …Meersmann, T. (2015). Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer. ChemPhysChem, 16(11), https://doi.org/10.1002/cphc.201500367

A new approach for hyperpolarized 129Xe molecular sensors is explored using paramagnetic relaxation agents that can be deactivated upon chemical or enzymatic reaction with an analyte. Cryptophane encapsulated 129Xe within the vicinity of the paramagn... Read More about Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer.

The relationship of speech intelligibility with hearing sensitivity, cognition, and perceived hearing difficulties varies for different speech perception tests (2015)
Journal Article
Heinrich, A., Henshaw, H., & Ferguson, M. A. (2015). The relationship of speech intelligibility with hearing sensitivity, cognition, and perceived hearing difficulties varies for different speech perception tests. Frontiers in Psychology, 6, https://doi.org/10.3389/fpsyg.2015.00782

Listeners vary in their ability to understand speech in noisy environments. Hearing sensitivity, as measured by pure-tone audiometry, can only partly explain these results, and cognition has emerged as another key concept. Although cognition relates... Read More about The relationship of speech intelligibility with hearing sensitivity, cognition, and perceived hearing difficulties varies for different speech perception tests.

Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388) (2015)
Journal Article
Beridze, M., Christensen, H., Dineen, R. A., Duley, L., Heptinstall, S., James, M., …Bath, P. M. (2015). Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388). International Journal of Stroke, 10(7), https://doi.org/10.1111/ijs.12538

RATIONALE: The risk of recurrence following a stroke or transient ischemic attack is high, especially immediately after the event. HYPOTHESIS: Because two antiplatelet agents are superior to one in patients with non-cardioembolic events, more... Read More about Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388).

Unraveling the multiscale structural organization and connectivity of the human brain: the role of diffusion MRI (2015)
Journal Article
Bastiani, M., & Roebroeck, A. (2015). Unraveling the multiscale structural organization and connectivity of the human brain: the role of diffusion MRI. Frontiers in Neuroanatomy, 9, https://doi.org/10.3389/fnana.2015.00077

The structural architecture and the anatomical connectivity of the human brain show different organizational principles at distinct spatial scales. Histological staining and light microscopy techniques have been widely used in classical neuroanatomic... Read More about Unraveling the multiscale structural organization and connectivity of the human brain: the role of diffusion MRI.

Brightness masking is modulated by disparity structure (2015)
Journal Article
Pelekanos, V., Ban, H., & Welchman, A. E. (2015). Brightness masking is modulated by disparity structure. Vision Research, 110(Part A), 87-92. https://doi.org/10.1016/j.visres.2015.02.010

The luminance contrast at the borders of a surface strongly influences surface’s apparent brightness, as demonstrated by a number of classic visual illusions. Such phenomena are compatible with a propagation mechanism believed to spread contrast info... Read More about Brightness masking is modulated by disparity structure.

Auditory training can improve working memory, attention, and communication in adverse conditions for adults with hearing loss (2015)
Journal Article
Ferguson, M. A., & Henshaw, H. (2015). Auditory training can improve working memory, attention, and communication in adverse conditions for adults with hearing loss. Frontiers in Psychology, 6, Article 556. https://doi.org/10.3389/FPG.2015.00556

Auditory training (AT) helps compensate for degradation in the auditory signal. A series of three high-quality training studies are discussed, which include, (i) a randomized controlled trial (RCT) of phoneme discrimination in quiet that trained adul... Read More about Auditory training can improve working memory, attention, and communication in adverse conditions for adults with hearing loss.

Development of a simple and sensitive HPLC-UV method for the simultaneous determination of cannabidiol and ?(9)-tetrahydrocannabinol in rat plasma (2015)
Journal Article
Zgair, A., Wong, J., Sabri, A., Fischer, P., Barrett, D., Constantinescu, C., & Gershkovich, P. (2015). Development of a simple and sensitive HPLC-UV method for the simultaneous determination of cannabidiol and ?(9)-tetrahydrocannabinol in rat plasma. Journal of Pharmaceutical and Biomedical Analysis, 114, 145-151. doi:10.1016/j.jpba.2015.05.019

Randomized phase 1b trial of MOR103, a human antibody to GM-CSF, in multiple sclerosis (2015)
Journal Article
Constantinescu, C. S., Asher, A., Fryze, W., Kozubski, W., Wagner, F., Aram, J., …Radue, E. W. (2015). Randomized phase 1b trial of MOR103, a human antibody to GM-CSF, in multiple sclerosis. Neurology, Neuroimmunology and Neuroinflammation, 2(4), Article e117. https://doi.org/10.1212/nxi.0000000000000117

Objectives: To determine the safety, pharmacokinetics (PK), and immunogenicity of the recombinant human monoclonal antibody MOR103 to granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with multiple sclerosis (MS) with clinical or... Read More about Randomized phase 1b trial of MOR103, a human antibody to GM-CSF, in multiple sclerosis.

Cortical cross-modal plasticity following deafness measured using functional near-infrared spectroscopy (2015)
Journal Article
Hartley, D. E., & Dewey, R. S. (2015). Cortical cross-modal plasticity following deafness measured using functional near-infrared spectroscopy. Hearing Research, 325, 55-63. https://doi.org/10.1016/j.heares.2015.03.007

Evidence from functional neuroimaging studies suggests that the auditory cortex can become more responsive to visual and somatosensory stimulation following deafness, and that this occurs predominately in the right hemisphere. Extensive cross-modal p... Read More about Cortical cross-modal plasticity following deafness measured using functional near-infrared spectroscopy.

Source space estimation of oscillatory power and brain connectivity in tinnitus (2015)
Journal Article
Palmer, A. R., Zobay, O., Hall, D. A., Sereda, M., & Adjamian, P. (2015). Source space estimation of oscillatory power and brain connectivity in tinnitus. PLoS ONE, 10(3), Article e0120123. https://doi.org/10.1371/journal.pone.0120123

© 2015 Zobay et al. Tinnitus is the perception of an internally generated sound that is postulated to emerge as a result of structural and functional changes in the brain. However, the precise pathophysiology of tinnitus remains unknown. Llinas' thal... Read More about Source space estimation of oscillatory power and brain connectivity in tinnitus.

Pharmacological treatment and prevention of cerebral small vessel disease: a review of potential interventions (2015)
Journal Article
Bath, P. M., & Wardlaw, J. M. (2015). Pharmacological treatment and prevention of cerebral small vessel disease: a review of potential interventions. International Journal of Stroke, 10(4), https://doi.org/10.1111/ijs.12466

Small vessel disease encompasses lacunar stroke, white matter hyperintensities, lacunes and microbleeds. It causes a quarter of all ischemic strokes, is the commonest cause of vascular dementia, and the cause is incompletely understood. Vascular prop... Read More about Pharmacological treatment and prevention of cerebral small vessel disease: a review of potential interventions.

Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis (2015)
Journal Article
Cook, K. W., Crooks, J., Hussain, K., O'Brien, K., Braitch, M., Kareem, H., …Gran, B. (2015). Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis. Frontiers in Microbiology, 6, Article 52. https://doi.org/10.3389/fmicb.2015.00052

Recent research has demonstrated that infection with the bacterial pathogen Helicobacter pylori is less common amongst patients with multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS). We aimed to compa... Read More about Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis.

The just-noticeable difference in speech-to-noise ratio (2015)
Journal Article
McShefferty, D., Whitmer, W. M., & Akeroyd, M. A. (2015). The just-noticeable difference in speech-to-noise ratio. Trends in Hearing, 19(1), https://doi.org/10.1177/2331216515572316

Just-noticeable differences (JNDs) have been measured for various features of sounds, but despite its importance to communication, there is no benchmark for what is a just-noticeable—and possibly meaningful—difference in speech-to-noise ratio (SNR).... Read More about The just-noticeable difference in speech-to-noise ratio.

Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil–DNA glycosylase impair learning in a mouse model of vascular cognitive impairment (2015)
Journal Article
Jadavji, N. M., Farr, T. D., Lips, J., Khalil, A. A., Boehm-Sturm, P., Foddis, M., …Dirnagl, U. (2015). Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil–DNA glycosylase impair learning in a mouse model of vascular cognitive impairment. Behavioural Brain Research, 283, https://doi.org/10.1016/j.bbr.2015.01.040

Dietary deficiencies in folic acid result in elevated levels of plasma homocysteine, which has been associated with the development of dementia and other neurodegenerative disorders. Previously, we have shown that elevated levels of plasma homocystei... Read More about Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil–DNA glycosylase impair learning in a mouse model of vascular cognitive impairment.

Prevalence and characteristics of spontaneous tinnitus in 11-year-old children (2015)
Journal Article
Baguley, D. M., Humphriss, R., & Hall, A. J. (2016). Prevalence and characteristics of spontaneous tinnitus in 11-year-old children. International Journal of Audiology, 55(3), 142-148. https://doi.org/10.3109/14992027.2015.1120890

Objective: To estimate the prevalence of spontaneous tinnitus in 11-year-old children. Design: A prospective UK population-based study. Study sample: A total of 7092 children from the Avon longitudinal study of parents and children (ALSPAC) who atten... Read More about Prevalence and characteristics of spontaneous tinnitus in 11-year-old children.

Do orally administered antibiotics reach concentrations in the middle ear sufficient to eradicate planktonic and biofilm bacteria?: a review (2015)
Journal Article
Belfield, K., Bayston, R., Birchall, J., & Daniel, M. (2015). Do orally administered antibiotics reach concentrations in the middle ear sufficient to eradicate planktonic and biofilm bacteria?: a review. International Journal of Pediatric Otorhinolaryngology, 79(3), 296-300. doi:10.1016/j.ijporl.2015.01.003

INTRODUCTION: Infectious conditions of the middle ear are a common and significant cause of morbidity and mortality worldwide. Systemic antibiotics are frequently used, but their effectiveness will depend on whether an adequate antibiotic concentrat... Read More about Do orally administered antibiotics reach concentrations in the middle ear sufficient to eradicate planktonic and biofilm bacteria?: a review.