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Unraveling the multiscale structural organization and connectivity of the human brain: the role of diffusion MRI

Bastiani, Matteo; Roebroeck, Alard

Unraveling the multiscale structural organization and connectivity of the human brain: the role of diffusion MRI Thumbnail


Authors

Matteo Bastiani

Alard Roebroeck



Abstract

The structural architecture and the anatomical connectivity of the human brain show different organizational principles at distinct spatial scales. Histological staining and light microscopy techniques have been widely used in classical neuroanatomical studies to unravel brain organization. Using such techniques is a laborious task performed on 2-dimensional histological sections by skilled anatomists possibly aided by semi-automated algorithms. With the recent advent of modern magnetic resonance imaging (MRI) contrast mechanisms, cortical layers and columns can now be reliably identified and their structural properties quantified post-mortem. These developments are allowing the investigation of neuroanatomical features of the brain at a spatial resolution that could be interfaced with that of histology. Diffusion MRI and tractography techniques, in particular, have been used to probe the architecture of both white and gray matter in three dimensions. Combined with mathematical network analysis, these techniques are increasingly influential in the investigation of the macro-, meso-, and microscopic organization of brain connectivity and anatomy, both in vivo and ex vivo. Diffusion MRI-based techniques in combination with histology approaches can therefore support the endeavor of creating multimodal atlases that take into account the different spatial scales or levels on which the brain is organized. The aim of this review is to illustrate and discuss the structural architecture and the anatomical connectivity of the human brain at different spatial scales and how recently developed diffusion MRI techniques can help investigate these.

Journal Article Type Article
Acceptance Date May 21, 2015
Online Publication Date Jun 9, 2015
Publication Date Jun 9, 2015
Deposit Date Oct 16, 2018
Publicly Available Date Oct 16, 2018
Journal Frontiers in Neuroanatomy
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 9
Article Number 77
DOI https://doi.org/10.3389/fnana.2015.00077
Keywords diffusion MRI, cortical layers and areas, cytoarchitecture, myeloachtecture, structural connectivity
Public URL https://nottingham-repository.worktribe.com/output/1169194
Publisher URL https://www.frontiersin.org/articles/10.3389/fnana.2015.00077/full

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