All Outputs (114)

Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic (2022)
Journal Article

One of the greatest challenges facing the medical community today is the ever-increasing trajectory of antimicrobial resistance (AMR), which is being compounded by the decrease in our antimicrobial armamentarium. From their initial discovery to the c... Read More about Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic.

Right fronto-parietal networks mediate the neurocognitive benefits of enriched environments (2022)
Journal Article

Exposure to enriched environments throughout a lifetime, providing so-called reserve, protects against cognitive decline in later years. It has been hypothesized that high levels of alertness necessitated by enriched environments might strengthen the... Read More about Right fronto-parietal networks mediate the neurocognitive benefits of enriched environments.

The association between inadequate sleep and accelerated brain ageing (2022)
Journal Article

Numerous studies indicate large heterogeneity in brain ageing, which can be attributed to modifiable lifestyle factors, including sleep. Inadequate sleep has been previously linked to gray (GM) and white (WM) matter changes. However, the reported fin... Read More about The association between inadequate sleep and accelerated brain ageing.

Effect of Tranexamic Acid Administration on Remote Cerebral Ischemic Lesions in Acute Spontaneous Intracerebral Hemorrhage: A Substudy of a Randomized Clinical Trial (2022)
Journal Article

Importance: Hyperintense foci on diffusion-weighted imaging (DWI) that are spatially remote from the acute hematoma occur in 20% of people with acute spontaneous intracerebral hemorrhage (ICH). Tranexamic acid, a hemostatic agent that is under invest... Read More about Effect of Tranexamic Acid Administration on Remote Cerebral Ischemic Lesions in Acute Spontaneous Intracerebral Hemorrhage: A Substudy of a Randomized Clinical Trial.

Optimising respiratory support for early COVID-19 pneumonia: a computational modelling study (2022)
Journal Article

Background: Optimal respiratory support in early COVID-19 pneumonia is controversial and remains unclear. Using computational modelling, we examined whether lung injury might be exacerbated in early COVID-19 by assessing the impact of conventional ox... Read More about Optimising respiratory support for early COVID-19 pneumonia: a computational modelling study.

Consensus Definition of Misophonia: A Delphi Study (2022)
Journal Article

Misophonia is a disorder of decreased tolerance to specific sounds or their associated stimuli that has been characterized using different language and methodologies. The absence of a common understanding or foundational definition of misophonia hind... Read More about Consensus Definition of Misophonia: A Delphi Study.

Association between time to treatment and clinical outcomes in endovascular thrombectomy beyond 6 hours without advanced imaging selection (2022)
Journal Article

Background: The effectiveness and safety of endovascular thrombectomy (EVT) in the late window (6-24 hours) for acute ischemic stroke (AIS) patients selected without advanced imaging is undetermined. We aimed to assess clinical outcomes and the relat... Read More about Association between time to treatment and clinical outcomes in endovascular thrombectomy beyond 6 hours without advanced imaging selection.

Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis (2022)
Journal Article

Understanding how neurohormonal gut-brain signaling regulates appetite and satiety is vital for the development of therapies for obesity and altered eating behavior. However, reported brain areas associated with appetite or satiety regulators show in... Read More about Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis.

Quantitative chemical exchange saturation transfer imaging of nuclear overhauser effects in acute ischemic stroke (2022)
Journal Article

Purpose: In chemical exchange saturation transfer imaging, saturation effects between (Formula presented.) 2 to (Formula presented.) 5 ppm (nuclear Overhauser effects, NOEs) have been shown to exhibit contrast in preclinical stroke models. Our previo... Read More about Quantitative chemical exchange saturation transfer imaging of nuclear overhauser effects in acute ischemic stroke.

Easy to interpret Coordinate Based Meta-Analysis of neuroimaging studies: Analysis of Brain Coordinates (ABC) (2022)
Journal Article

Background: Functional MRI and voxel-based morphometry are important in neuroscience. They are technically challenging with no globally optimal analysis method, and the multiple approaches have been shown to produce different results. It is useful to... Read More about Easy to interpret Coordinate Based Meta-Analysis of neuroimaging studies: Analysis of Brain Coordinates (ABC).

Experiences of receiving a diagnosis of multiple sclerosis: a meta-synthesis of qualitative studies (2022)
Journal Article

Purpose: This meta-synthesis aimed to synthesise qualitative evidence on experiences of people with Multiple Sclerosis (MS) in receiving a diagnosis, to derive a conceptual understanding of adjustment to MS diagnosis. Methods: Five electronic databas... Read More about Experiences of receiving a diagnosis of multiple sclerosis: a meta-synthesis of qualitative studies.

Dataset of British English speech recordings for psychoacoustics and speech processing research: The clarity speech corpus (2022)
Journal Article

This paper presents the Clarity Speech Corpus, a publicly available, forty speaker British English speech dataset. The corpus was created for the purpose of running listening tests to gauge speech intelligibility and quality in the Clarity Project, w... Read More about Dataset of British English speech recordings for psychoacoustics and speech processing research: The clarity speech corpus.

Concurrent mapping of brain ontogeny and phylogeny within a common connectivity space (2022)
Working Paper

Developmental and evolutionary effects on brain organisation are complex, yet linked, as evidenced by the striking correspondence in cortical expansion changes. However, it is still not possible to study concurrently the ontogeny and phylogeny of cor... Read More about Concurrent mapping of brain ontogeny and phylogeny within a common connectivity space.

Smartphone App–Based Noncontact Ecological Momentary Assessment With Experienced and Naïve Older Participants: Feasibility Study (2022)
Journal Article

Background: Smartphone app–based ecological momentary assessment (EMA) without face-to-face contact between researcher and participant (app-based noncontact EMA) potentially provides a valuable data collection tool when geographic, time, and situati... Read More about Smartphone App–Based Noncontact Ecological Momentary Assessment With Experienced and Naïve Older Participants: Feasibility Study.

Complementary and Alternative Medicine and Tinnitus (2022)
Book Chapter

An Exploratory Investigation of Pupillometry As a Measure of Tinnitus Intrusiveness on a Test of Auditory Short-Term Memory (2022)
Journal Article

Objectives: The purpose of the current study was to investigate the potential of pupillometry to provide an objective measure of competition between tinnitus and external sounds during a test of auditory short-term memory. Design: Twelve participants... Read More about An Exploratory Investigation of Pupillometry As a Measure of Tinnitus Intrusiveness on a Test of Auditory Short-Term Memory.

Evaluation of home-delivered live-voice auditory training for adult hearing aid users involving their communication partners: a randomised controlled trial (2022)
Journal Article

Objective: To examine the benefits of home-delivered auditory training for adult hearing aid users using live-voice conversations in the presence of a single-talker distractor (experimental group) or in quiet (active-control group). Design: Randomise... Read More about Evaluation of home-delivered live-voice auditory training for adult hearing aid users involving their communication partners: a randomised controlled trial.

Outgrowth endothelial progenitor cells restore cerebral barrier function following ischaemic damage: the impact of NOX2 inhibition (2022)
Journal Article

Disruption of blood-brain barrier (BBB), formed mainly by human brain microvascular endothelial cells (HBMECs), constitutes the major cause of mortality following ischaemic stroke. This study investigates whether OECs (outgrowth endothelial cells) ca... Read More about Outgrowth endothelial progenitor cells restore cerebral barrier function following ischaemic damage: the impact of NOX2 inhibition.

Rate and severity of radiological features of physical abuse in children during the first UK-wide COVID-19 enforced national lockdown (2022)
Journal Article

Objective To assess the number, type and outcome of radiological investigations for children presenting to hospital with suspected physical abuse (SPA; including abusive head trauma) during the first national COVID-19 enforced lockdown compared with... Read More about Rate and severity of radiological features of physical abuse in children during the first UK-wide COVID-19 enforced national lockdown.

The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure (2022)
Journal Article

The COVID-19 pandemic resulted in catastrophic levels of morbidity and mortality for care home residents. Despite this, research platforms for COVID-19 in care homes arrived late in the pandemic compared with other care settings. The Prophylactic The... Read More about The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure.