Jivesh Ramduny
The association between inadequate sleep and accelerated brain ageing
Ramduny, Jivesh; Bastiani, Matteo; Huedepohl, Robin; Sotiropoulos, Stamatios N.; Chechlacz, Magdalena
Authors
Matteo Bastiani
Robin Huedepohl
STAMATIOS SOTIROPOULOS STAMATIOS.SOTIROPOULOS@NOTTINGHAM.AC.UK
Professor of Computational Neuroimaging
Magdalena Chechlacz
Abstract
Numerous studies indicate large heterogeneity in brain ageing, which can be attributed to modifiable lifestyle factors, including sleep. Inadequate sleep has been previously linked to gray (GM) and white (WM) matter changes. However, the reported findings are highly inconsistent. By contrast to previous research independently characterizing patterns of either GM or WM changes, we used here linked independent component analysis (FLICA) to examine covariation in GM, and WM in a group of older adults (n = 50). Next, we employed a novel technique to estimate the brain age delta (difference between chronological and brain age assessed using neuroimaging data) and study its associations with sleep quality and sleep fragmentation, hypothesizing that inadequate sleep accelerates brain ageing. FLICA revealed a number of multimodal components, associated with age, sleep quality, and sleep fragmentation. Subsequently, we show significant associations between brain age delta and inadequate sleep, suggesting 2 years deviation above the chronological age. Our findings indicate sensitivity of multimodal approaches and brain age delta in detecting link between inadequate sleep and accelerated brain ageing.
Citation
Ramduny, J., Bastiani, M., Huedepohl, R., Sotiropoulos, S. N., & Chechlacz, M. (2022). The association between inadequate sleep and accelerated brain ageing. Neurobiology of Aging, 114, 1-14. https://doi.org/10.1016/j.neurobiolaging.2022.02.005
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 14, 2022 |
Online Publication Date | Mar 25, 2022 |
Publication Date | Jun 1, 2022 |
Deposit Date | Feb 23, 2022 |
Publicly Available Date | Apr 6, 2022 |
Journal | Neurobiology of Aging |
Print ISSN | 0197-4580 |
Electronic ISSN | 1558-1497 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 114 |
Pages | 1-14 |
DOI | https://doi.org/10.1016/j.neurobiolaging.2022.02.005 |
Keywords | Geriatrics and Gerontology; Developmental Biology; Neurology (clinical); Aging; General Neuroscience |
Public URL | https://nottingham-repository.worktribe.com/output/7477529 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S0197458022000264?via%3Dihub |
Files
The association between inadequate sleep and accelerated brain ageing
(2.9 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
You might also like
Ball and rackets: inferring fiber fanning from diffusion-weighted MRI
(2012)
Journal Article
The topographic connectome
(2013)
Journal Article
The minimal preprocessing pipelines for the Human Connectome Project
(2013)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search