All Outputs (133)

Cerebellar repetitive transcranial magnetic stimulation restores pharyngeal brain activity and swallowing behaviour after disruption by a cortical virtual lesion (2019)
Journal Article
Sasegbon, A., Watanabe, M., Simons, A., Michou, E., Vasant, D. H., Magara, J., Bath, P. M., Rothwell, J., Inoue, M., & Hamdy, S. (2019). Cerebellar repetitive transcranial magnetic stimulation restores pharyngeal brain activity and swallowing behaviour after disruption by a cortical virtual lesion. Journal of Physiology, 597(9), 2533-2546. https://doi.org/10.1113/jp277545

Repetitive transcranial magnetic stimulation (rTMS) can alter neuronal activity within the brain with therapeutic potential. Low frequency stimulation to the ‘dominant’ cortical swallowing projection induces a ‘virtual‐lesion’ transiently suppressing... Read More about Cerebellar repetitive transcranial magnetic stimulation restores pharyngeal brain activity and swallowing behaviour after disruption by a cortical virtual lesion.

It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis (2019)
Journal Article
Appleton, J. P., Woodhouse, L. J., Belcher, A., Bereczki, D., Berge, E., Caso, V., Chang, H. M., Christensen, H. K., Collins, R., Gommans, J., Laska, A. C., Ntaios, G., Ozturk, S., Sare, G. M., Szatmari, S., Wang, Y., Wardlaw, J. M., Sprigg, N., & Bath, P. M. (2019). It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis. Stroke and Vascular Neurology, 4(1), 28-35. https://doi.org/10.1136/svn-2019-000232

Background There is concern that blood pressure (BP) lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis. We assessed the effect of glyceryl trinitrate (GTN) in patients with carotid steno... Read More about It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis.

Effects of tinnitus on cochlear implant programming (2019)
Journal Article
Pierzycki, R. H., Corner, C., Fielden, C. A., & Kitterick, P. T. (2019). Effects of tinnitus on cochlear implant programming. Trends in Hearing, 23, https://doi.org/10.1177/2331216519836624

Clinical observations suggest that tinnitus may interfere with programming cochlear implants (CIs), the process of optimizing the transmission of acoustic information to support speech perception with a CI. Despite tinnitus being highly prevalent amo... Read More about Effects of tinnitus on cochlear implant programming.

Exploring the experiences of cancer patients with chemotherapy induced ototoxicity: qualitative study using online health forums (2019)
Journal Article
Pearson, S. E., Taylor, J. A., Hoare, D. J., Patel, P., & Baguley, D. M. (2019). Exploring the experiences of cancer patients with chemotherapy induced ototoxicity: qualitative study using online health forums. JMIR Cancer, 5(1), Article e10883. https://doi.org/10.2196/10883

Background: Many cancer patients and survivors experience permanent and life-debilitating effects, such as ototoxicity, from treatment. Ototoxicity manifests as high-frequency hearing loss and tinnitus, which can have a detrimental effect on the qual... Read More about Exploring the experiences of cancer patients with chemotherapy induced ototoxicity: qualitative study using online health forums.

Short-term morbidity factors associated with length of hospital stay (LOS): development and validation of a hip fracture specific postoperative morbidity survey (HF-POMS) (2019)
Journal Article
Moppett, I. (2019). Short-term morbidity factors associated with length of hospital stay (LOS): development and validation of a hip fracture specific postoperative morbidity survey (HF-POMS). Injury, 50(4), 931-938. https://doi.org/10.1016/j.injury.2019.03.009

Background: We aimed to describe and quantify postoperative complications in the older hip fracture population, develop and validate a hip fracture postoperative morbidity survey tool (HF–POMS).

Methods: A prospective clinical observation study o... Read More about Short-term morbidity factors associated with length of hospital stay (LOS): development and validation of a hip fracture specific postoperative morbidity survey (HF-POMS).

The social value of the arts for care home residents in England: A Social Return on Investment (SROI) analysis of the Imagine Arts programme (2019)
Journal Article
Bosco, A., Schneider, J., & Broome, E. (2019). The social value of the arts for care home residents in England: A Social Return on Investment (SROI) analysis of the Imagine Arts programme. Maturitas, 124, 15-24. https://doi.org/10.1016/j.maturitas.2019.02.005

Misophonia: A scoping review of research (2019)
Journal Article
Potgieter, I., MacDonald, C., Partridge, L., Cima, R., Sheldrake, J., & Hoare, D. J. (2019). Misophonia: A scoping review of research. Journal of Clinical Psychology, 75(7), 1203-1218. https://doi.org/10.1002/jclp.22771

Objective
To scope the literature describing misophonia populations, management, and research opportunities.

Method
Literature searches for research studies describing patients diagnosed with misophonia, defining a patient profile, or outlining... Read More about Misophonia: A scoping review of research.

MRS and DTI evidence of progressive posterior cingulate cortex and corpus callosum injury in the hyper-acute phase after Traumatic Brain Injury (2019)
Journal Article
Lawrence, T. P., Steel, A., Ezra, M., Speirs, M., Pretorius, P. M., Douaud, G., Sotiropoulos, S., Cadoux-Hudson, T., Emir, U. E., & Voets, N. L. (2019). MRS and DTI evidence of progressive posterior cingulate cortex and corpus callosum injury in the hyper-acute phase after Traumatic Brain Injury. Brain Injury, 33(7), 854-868. https://doi.org/10.1080/02699052.2019.1584332

The posterior cingulate cortex (PCC) and corpus callosum (CC) are susceptible to trauma, but injury often evades detection. PCC Metabolic disruption may predict CC white matter tract injury and the secondary cascade responsible for progression. While... Read More about MRS and DTI evidence of progressive posterior cingulate cortex and corpus callosum injury in the hyper-acute phase after Traumatic Brain Injury.

The genetic vulnerability to cisplatin ototoxicity: a systematic review (2019)
Journal Article
Edvall, N. K., Cederroth, C. R., Tserga, E., Nandwani, T., Edvall, N. K., Bulla, J., Patel, P., Canlon, B., Cederroth, C. R., & Baguley, D. M. (2019). The genetic vulnerability to cisplatin ototoxicity: a systematic review. Scientific Reports, 9, Article 3455. https://doi.org/10.1038/s41598-019-40138-z

Ototoxicity is one of the major side-effects of platinum-based chemotherapy, in particular cisplatin (cis-diammine dichloroplatinum II). To our knowledge, no systematic review has previously provided a quantitative summary estimate of the impact of g... Read More about The genetic vulnerability to cisplatin ototoxicity: a systematic review.

High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging (2019)
Journal Article
van der Plas, M. C., Teeuwisse, W. M., Schmid, S., Chappell, M., & van Osch, M. J. (2019). High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging. Magnetic Resonance in Medicine, 81(6), 3734-3744. https://doi.org/10.1002/mrm.27692

Purpose
The goal of this study was to achieve high temporal resolution, multi‐time point pseudo‐continuous arterial spin labeling (pCASL) MRI in a time‐efficient manner, while maintaining whole‐brain coverage.

Methods
A Hadamard 8‐matrix was use... Read More about High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging.

Standardised profiling for tinnitus research: the European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ) (2019)
Journal Article
Genitsaridi, E., Partyka, M., Gallus, S., Lopez-Escamez, J. A., Schecklmann, M., Mielczarek, M., Trpchevska, N., Santacruz, J. L., Schoisswohl, S., Riha, C., Lourenco, M., Biswas, R., Liyanage, N., Cederroth, C. R., Perez-Carpena, P., Devos, J., Fuller, T., Edvall, N. K., Hellberg, M. P., D'Antonio, A., …Hall, D. A. (2019). Standardised profiling for tinnitus research: the European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ). Hearing Research, 377, 353-359. https://doi.org/10.1016/j.heares.2019.02.017

Background
The heterogeneity of tinnitus is substantial. Its numerous pathophysiological mechanisms and clinical manifestations have hampered fundamental and treatment research significantly. A decade ago, the Tinnitus Research Initiative introduced... Read More about Standardised profiling for tinnitus research: the European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ).

Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement (2019)
Journal Article
Faas, H. M., Krupa, J. L., Taylor, A. J., Zamberlan, F., Philp, C. J., Williams, H. E., Johnson, S. R., Pavlovskaya, G. E., Thomas, N. R., & Meersmann, T. (2019). Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement. Contrast Media and Molecular Imaging, 2019, 1-13. https://doi.org/10.1155/2019/4826520

Paramagnetic gadolinium ions (Gd III), complexed within DOTA-based chelates, have become useful tools to increase the magnetic resonance imaging (MRI) contrast in tissues of interest. Recently, " on/off " probes serving as 19 F·MRI biosensor for targ... Read More about Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement.

Acute dual antiplatelet therapy for minor ischaemic stroke or transient ischaemic attack (2019)
Journal Article
Wang, Y., Johnston, S. C., Bath, P. M., Grotta, J. C., Pan, Y., Amarenco, P., Wang, Y., Simon, T., Kim, J. S., Jeng, J.-S., Liu, L., Lin, Y., Wong, K. S. L., Wang, D., & Li, H. (2019). Acute dual antiplatelet therapy for minor ischaemic stroke or transient ischaemic attack. BMJ, 364, Article l895. https://doi.org/10.1136/bmj.l895

Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation (2019)
Journal Article
Xing, Y., Tench, C., Wongwandee, M., Schwarz, S., Bajaj, N., & Auer, D. (2020). Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation. Brain Imaging and Behavior, 14(4), 1263–1280. https://doi.org/10.1007/s11682-019-00061-3

Objective
To investigate factors affecting the pattern of motor brain activation reported in people with Parkinson’s (PwP), aiming to differentiate disease-specific features from treatment effects.

Methods
A co-ordinate-based-meta-analysis (CBMA... Read More about Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation.

Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model (2019)
Journal Article
Morales, M. L. O., Marsit, N. M., McIntosh, O. D., Hopkinson, A., & Sidney, L. E. (2019). Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model. World Journal of Stem Cells, 11(2), 84-99. https://doi.org/10.4252/wjsc.v11.i2.84

BACKGROUND
An in vitro injury model mimicking a corneal surface injury was optimised using human corneal epithelial cells (hCEC).

AIM
To investigate whether corneal-stroma derived stem cells (CSSC) seeded on an amniotic membrane (AM) construct m... Read More about Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model.

Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international randomised, open-label, blinded-endpoint phase 3 trial (2019)
Journal Article
Anderson, C. S., Huang, Y., Lindley, R. I., Chen, X., Arima, H., Chen, G., Li, Q., Billot, L., Delcourt, C., Bath, P. M., Broderick, J. P., Demchuk, A. M., Donnan, G. A., Durham, A. C., Lavados, P. M., Lee, T.-H., Levi, C., Martins, S. O., Olavarria, V. V., Pandian, J. D., …ENCHANTED Investigators and Coordinators. (2019). Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international randomised, open-label, blinded-endpoint phase 3 trial. Lancet, 393(10174), 877-888. https://doi.org/10.1016/S0140-6736%2819%2930038-8

Hierarchical heterogeneity across human cortex shapes large-scale neural dynamics (2019)
Journal Article
Demirtas, M., Burt, J. B., Helmer, M., Ji, J. L., Adkinson, B. D., Glasser, M. F., Van Essen, D. C., Sotiropoulos, S. N., Anticevic, A., & Murray, J. D. (2019). Hierarchical heterogeneity across human cortex shapes large-scale neural dynamics. Neuron, 101(6), 1181-1194.e13. https://doi.org/10.1016/j.neuron.2019.01.017

The large-scale organization of dynamical neural activity across cortex emerges through long-range interactions among local circuits. We hypothesized that large-scale dynamics are also shaped by heterogeneity of intrinsic local properties across cort... Read More about Hierarchical heterogeneity across human cortex shapes large-scale neural dynamics.

Effective chair training methods for neuroscience research involving rhesus macaques (Macaca mulatta) (2019)
Journal Article
Mason, S., Premereur, E., Pelekanos, V., Emberton, A., Honess, P., & Mitchell, A. S. (2019). Effective chair training methods for neuroscience research involving rhesus macaques (Macaca mulatta). Journal of Neuroscience Methods, 317, 82-93. https://doi.org/10.1016/j.jneumeth.2019.02.001

© 2019 The Authors Background: Neuroscience research using macaques remains fundamental in our endeavours to understand how the human brain functions. Applying the refinement principle of the 3Rs is essential to optimise the monkeys’ welfare and stil... Read More about Effective chair training methods for neuroscience research involving rhesus macaques (Macaca mulatta).

Complement Factor H Mutation W1206R Causes Retinal Thrombosis and Ischemic Retinopathy in Mice (2019)
Journal Article
Song, D., Ueda, Y., Bhuyan, R., Mohammed, I., Miwa, T., Gullipali, D., Kim, H., Zhou, L., Song, Y., Schultz, H., Bargoud, A., Dunaief, J. L., & Song, W.-C. (2019). Complement Factor H Mutation W1206R Causes Retinal Thrombosis and Ischemic Retinopathy in Mice. American Journal of Pathology, 189(4), 826-838. https://doi.org/10.1016/j.ajpath.2019.01.009

© 2019 American Society for Investigative Pathology Single-nucleotide polymorphisms and rare mutations in factor H (FH; official name, CFH) are associated with age-related macular degeneration and atypical hemolytic uremic syndrome, a form of thromb... Read More about Complement Factor H Mutation W1206R Causes Retinal Thrombosis and Ischemic Retinopathy in Mice.

Discrimination of Gain Increments in Speech (2019)
Journal Article
Caswell-Midwinter, B., & Whitmer, W. M. (2019). Discrimination of Gain Increments in Speech. Trends in Hearing, 23, 233121651988668. https://doi.org/10.1177/2331216519886684

© The Author(s) 2019. During a hearing-aid fitting, the gain applied across frequencies is often adjusted from an initial prescription in order to meet individual needs and preferences. These gain adjustments in one or more frequency bands are common... Read More about Discrimination of Gain Increments in Speech.