Cerebellar repetitive transcranial magnetic stimulation restores pharyngeal brain activity and swallowing behaviour after disruption by a cortical virtual lesion

Sasegbon, Ayodele; Watanabe, Masahiro; Simons, Andre; Michou, Emilia; Vasant, Dipesh H.; Magara, Jin; Bath, Philip M.; Rothwell, John; Inoue, Makoto; Hamdy, Shaheen

Abstract

Repetitive transcranial magnetic stimulation (rTMS) can alter neuronal activity within the brain with therapeutic potential. Low frequency stimulation to the ‘dominant’ cortical swallowing projection induces a ‘virtual‐lesion’ transiently suppressing cortical excitability and disrupting swallowing behaviour. Here, we compared the ability of ipsi‐lesional, contra‐lesional and sham cerebellar rTMS to reverse the effects of a ‘virtual‐lesion’ in health. Two groups of healthy participants (n = 15/group) were intubated with pharyngeal catheters. Baseline pharyngeal motor evoked potentials (PMEPs) and swallowing performance (reaction task) were measured. Participants received 10 min of 1 Hz rTMS to the pharyngeal motor cortex which elicited the largest PMEPs to suppress cortical activity and disrupt swallowing behaviour. Over six visits, participants were randomized to receive 250 pulses of 10 Hz cerebellar rTMS to the ipsi‐lesional side, contra‐lesional side or sham while assessing PMEP amplitude or swallowing performance for an hour afterwards. Compared to sham, active cerebellar rTMS, whether administered ipsi‐lesionally (P = 0.011) or contra‐lesionally (P = 0.005), reversed the inhibitory effects of the cortical ‘virtual‐lesion’ on PMEPs and swallowing accuracy (ipsi‐lesional, P < 0.001, contra‐lesional, P < 0.001). Cerebellar rTMS was able to reverse the disruptive effects of a ‘virtual lesion’. These findings provide evidence for developing cerebellar rTMS into a treatment for post‐stroke dysphagia.

• Journal Article Type: Article
• Acceptance Date: Mar 21, 2019
• Online Publication Date: Mar 25, 2019
• Publication Date: May 1, 2019
• Deposit Date: May 3, 2019
• Publicly Available Date: May 3, 2019
• Journal: The Journal of Physiology
• Print ISSN: 0022-3751
• Electronic ISSN: 1469-7793
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 597
• Issue: 9
• Pages: 2533-2546
• DOI: https://doi.org/10.1113/jp277545
• Keywords: Physiology
• Public URL: https://nottingham-repository.worktribe.com/output/2019047
• Publisher URL: https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP277545