All Outputs (128)

Sound therapy (using amplification devices and/or sound generators) for tinnitus (2018)
Journal Article

BACKGROUND: Tinnitus affects 10% to 15% of the adult population, with about 20% of these experiencing symptoms that negatively affect quality of life. In England alone there are an estimated ¾ million general practice consultations every year where t... Read More about Sound therapy (using amplification devices and/or sound generators) for tinnitus.

A general framework for optimizing arterial spin labeling MRI experiments (2018)
Journal Article

Purpose Arterial spin labeling (ASL) MRI is a non‐invasive perfusion imaging technique that is inherently SNR limited, so scan protocols ideally need to be rigorously optimized to provide the most accurate measurements. A general framework is presen... Read More about A general framework for optimizing arterial spin labeling MRI experiments.

In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft (2018)
Journal Article

The advent of innovative surgical procedures utilizing partial thickness corneal grafts has created a need for the development of synthetic implants to recreate corneal stromal tissue. This work evaluates electrospun gelatin and polycaprolactone (PCL... Read More about In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft.

Assessing the ex vivo permeation behaviour of functionalised contact lens coatings engineered using an electrohydrodynamic technique (2018)
Journal Article

In vitro testing alone is no longer considered sufficient evidence presented solely with respect to drug release and permeation testing. These studies are thought to be more reliable and representative when using tissue or animal models; as opposed t... Read More about Assessing the ex vivo permeation behaviour of functionalised contact lens coatings engineered using an electrohydrodynamic technique.

The relationship between patients’ illness beliefs and recovery after stroke (2018)
Journal Article

The Common Sense Model (CSM) is a useful framework for understanding mood and treatment adherence amongst survivors in the acute phase of stroke. CSM stroke studies have thus far focused on the single outcomes, mood and medication adherence, neglecti... Read More about The relationship between patients’ illness beliefs and recovery after stroke.

Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea (2018)
Journal Article

Background Apnoeic oxygenation can come close to matching the oxygen demands of the apnoeic patient but does not facilitate carbon dioxide (CO2) elimination, potentially resulting in dangerous hypercapnia. Numerous studies have shown that high-flo... Read More about Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea.

Aberrant visual pathway development in albinism: from retina to cortex (2018)
Journal Article

Albinism refers to a group of genetic abnormalities in melanogenesis that are associated neuronal misrouting through the optic chiasm. Previous imaging studies have shown structural alterations at different points along the visual pathway of people w... Read More about Aberrant visual pathway development in albinism: from retina to cortex.

The COMiT'ID study: developing core outcome domains sets for clinical trials of sound-, psychology-, and pharmacology-based interventions for chronic subjective tinnitus in adults (2018)
Journal Article

Subjective tinnitus is a chronic heterogeneous condition that is typically managed using intervention approaches based on sound devices, psychologically informed therapies, or pharmaceutical products. For clinical trials, there are currently no commo... Read More about The COMiT'ID study: developing core outcome domains sets for clinical trials of sound-, psychology-, and pharmacology-based interventions for chronic subjective tinnitus in adults.

Why Is Tinnitus a Problem? A Qualitative Analysis of Problems Reported by Tinnitus Patients (2018)
Journal Article

Tinnitus is a prevalent complaint, and people with bothersome tinnitus can report any number of associated problems. Yet, to date, only a few studies, with different populations and relatively modest sample sizes, have qualitatively evaluated what th... Read More about Why Is Tinnitus a Problem? A Qualitative Analysis of Problems Reported by Tinnitus Patients.

Pathophysiology of subjective tinnitus: triggers and maintenance (2018)
Journal Article

Tinnitus is the conscious perception of a sound without a corresponding external acoustic stimulus, usually described as a phantom perception. One of the major challenges for tinnitus research is to understand the pathophysiological mechanisms trigge... Read More about Pathophysiology of subjective tinnitus: triggers and maintenance.

Central adjudication of serious events did not affect trial's safety results: data from the Efficacy of Nitric Acid in Stroke (ENOS trial) (2018)
Journal Article

Background and Purpose: Central adjudication of serious adverse events (SAEs) can be undertaken in clinical trials, especially for open-label studies where outcome assessment may be at risk of bias. This study explored the effect of central adjudicat... Read More about Central adjudication of serious events did not affect trial's safety results: data from the Efficacy of Nitric Acid in Stroke (ENOS trial).

Baseline characteristics of the 1149 patients recruited into the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) randomized controlled trial (2018)
Journal Article

Background: High blood pressure (BP) is common in acute stroke and associated with a worse functional outcome. Glyceryl trinitrate (GTN), a nitric oxide donor, lowers BP in acute stroke and may improve outcome. Aims: RIGHT-2 tested the feasibility o... Read More about Baseline characteristics of the 1149 patients recruited into the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) randomized controlled trial.

Pathogenese und Epidemiologie der neurotrophen Keratopathie (2018)
Journal Article

Internet-based interventions for adults with hearing loss, tinnitus and vestibular disorders: a protocol for a systematic review (2018)
Journal Article

© 2018 The Author(s). Background: Internet-based interventions are emerging as an alternative way of delivering accessible healthcare for various conditions including hearing and balance disorders. A comprehensive review regarding the evidence-base o... Read More about Internet-based interventions for adults with hearing loss, tinnitus and vestibular disorders: a protocol for a systematic review.

Assessing Reliability of Myocardial Blood Flow After Motion Correction With Dynamic PET Using a Bayesian Framework (2018)
Journal Article

The estimation of myocardial blood flow (MBF) in dynamic PET can be biased by many different processes. A major source of error, particularly in clinical applications, is patient motion. Patient motion, or gross motion, creates displacements between... Read More about Assessing Reliability of Myocardial Blood Flow After Motion Correction With Dynamic PET Using a Bayesian Framework.

Innovation in the Context of Audiology and in the Context of the Internet (2018)
Journal Article

Purpose: This article explores different meanings of innovation within the context of audiology and the internet. Case studies are used to illustrate and elaborate on the new types of innovation and their levels of impact. Method: The article defi... Read More about Innovation in the Context of Audiology and in the Context of the Internet.

An application of the Medical Research Council’s guidelines for evaluating complex interventions: a usability study assessing Smartphone-connected listening devices in adults with hearing loss (2018)
Journal Article

Purpose: To provide an example of the Medical Research Council’s (MRC’s) guidelines for evaluating complex healthcare interventions in the context of Smartphone-connected listening devices in adults with hearing loss. Method: Twenty existing hearing... Read More about An application of the Medical Research Council’s guidelines for evaluating complex interventions: a usability study assessing Smartphone-connected listening devices in adults with hearing loss.

Long-Term Efficacy of Audiologist-Guided Internet-Based Cognitive Behavior Therapy for Tinnitus (2018)
Journal Article

Purpose: The purpose of this study was to investigate the long-term outcomes 1 year after undertaking an audiologist-guided Internet-based cognitive behavioral therapy (iCBT) intervention for tinnitus. Secondary aims were to identify any predictors o... Read More about Long-Term Efficacy of Audiologist-Guided Internet-Based Cognitive Behavior Therapy for Tinnitus.

Findings and Ethical Considerations From a Thematic Analysis of Threads Within Tinnitus Online Support Groups (2018)
Journal Article

Purpose: Tinnitus is the perception of noise without a corresponding external stimulus. Current management typically aims to moderate associated psychosocial stressors and allow sufferers to retain an adequate quality of life. With the increasing rec... Read More about Findings and Ethical Considerations From a Thematic Analysis of Threads Within Tinnitus Online Support Groups.

Lifespan pigmentation changes of the substantia nigra detected by neuromelanin-sensitive MRI (2018)
Journal Article

Background: Neuromelanin is a pigment with strong iron-chelating properties preferentially found in dopaminergic neurons of the substantia nigra, pars compacta (SNpc). Parkinson's disease is characterized by pronounced, MRI detectable neuromelanin lo... Read More about Lifespan pigmentation changes of the substantia nigra detected by neuromelanin-sensitive MRI.