All Outputs (129)

Audiometric profiles and patterns of benefit: a data-driven analysis of subjective hearing difficulties and handicaps (2021)
Journal Article
Sanchez-Lopez, R., Dau, T., & Whitmer, W. M. (2022). Audiometric profiles and patterns of benefit: a data-driven analysis of subjective hearing difficulties and handicaps. International Journal of Audiology, 61(4), 301-310. https://doi.org/10.1080/14992027.2021.1905890

Objective: Hearing rehabilitation attempts to compensate for auditory dysfunction, reduce hearing difficulties and minimize participation restrictions that can lead to social isolation. However, there is no systematic approach to assess the quality o... Read More about Audiometric profiles and patterns of benefit: a data-driven analysis of subjective hearing difficulties and handicaps.

Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study (2021)
Journal Article
Espinosa-Sanchez, J. M., Lopez-Escamez, J. A., Cederroth, C. R., Canlon, B., May, P., Aran, I., …Gallego-Martinez, A. (2021). Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study. EBioMedicine, 66, Article 103309. https://doi.org/10.1016/j.ebiom.2021.103309

Background: tinnitus is a heterogeneous condition associated with audiological and/or mental disorders. Chronic, severe tinnitus is reported in 1% of the population and it shows a relevant heritability, according to twins, adoptees and familial aggr... Read More about Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study.

A measure of long-term hearing-aid use persistence based on battery re-ordering data (2021)
Journal Article
Zobay, O., Dillard, L. K., Naylor, G., & Saunders, G. H. (2021). A measure of long-term hearing-aid use persistence based on battery re-ordering data. Ear and Hearing, 42(5), 1441-1444. https://doi.org/10.1097/AUD.0000000000001032

Objective: We describe the construction of a hearing-aid long-term use persistence measure based on battery reorder data. The measure is derived from the notion that hearing-aid users keep using their devices for some time after placing a battery... Read More about A measure of long-term hearing-aid use persistence based on battery re-ordering data.

Study Protocol: The Heart and Brain Study (2021)
Journal Article
Suri, S., Bulte, D., Chiesa, S. T., Ebmeier, K. P., Jezzard, P., Rieger, S. W., …Mackay, C. E. (2021). Study Protocol: The Heart and Brain Study. Frontiers in Physiology, 12, Article 643725. https://doi.org/10.3389/fphys.2021.643725

Background: It is well-established that what is good for the heart is good for the brain. Vascular factors such as hypertension, diabetes, and high cholesterol, and genetic factors such as the apolipoprotein E4 allele increase the risk of developing... Read More about Study Protocol: The Heart and Brain Study.

Tinnitus and its associations with general health, mental health and hearing loss (2021)
Book Chapter
Stegeman, I., Eikelboom, R. H., Smit, A. L., Baguley, D. M., Bucks, R. S., Stokroos, R. J., …Atlas, M. D. (2021). Tinnitus and its associations with general health, mental health and hearing loss. . Elsevier. https://doi.org/10.1016/bs.pbr.2021.01.023

Background: A deeper knowledge of tinnitus is essential in order to better manage and treat tinnitus and its effects. Most studies to date are based on small samples and/or conducted in clinical settings. In this study we assessed the associations be... Read More about Tinnitus and its associations with general health, mental health and hearing loss.

Quantitative T1 mapping using multi-slice multi-shot inversion recovery EPI (2021)
Journal Article
Sanchez Panchuelo, R. M., Mougin, O., Turner, R., & Francis, S. T. (2021). Quantitative T1 mapping using multi-slice multi-shot inversion recovery EPI. NeuroImage, 234, Article 117976. https://doi.org/10.1016/j.neuroimage.2021.117976

An efficient multi-slice inversion–recovery EPI (MS-IR-EPI) sequence for fast, high spatial resolution, quantitative T1 mapping is presented, using a segmented simultaneous multi-slice acquisition, combined with slice order shifting across multiple a... Read More about Quantitative T1 mapping using multi-slice multi-shot inversion recovery EPI.

Determining the effects of transcranial direct current stimulation on tinnitus and tinnitus-related outcomes: protocol for a systematic review (2021)
Journal Article
Labree, B., Hoare, D. J., Gascoyne, L. E., & Sereda, M. (2021). Determining the effects of transcranial direct current stimulation on tinnitus and tinnitus-related outcomes: protocol for a systematic review. BMJ Open, 11(3), 1-6. https://doi.org/10.1136/bmjopen-2020-047191

Introduction: Tinnitus is the awareness of a sound in the ear or head in the absence of an external source. It affects around 10%–15% of people. About 20% of people with tinnitus also experience symptoms such as depression or anxiety that negatively... Read More about Determining the effects of transcranial direct current stimulation on tinnitus and tinnitus-related outcomes: protocol for a systematic review.

Systematic review of outcome domains and instruments used in designs of clinical trials for interventions that seek to restore bilateral and binaural hearing in adults with unilateral severe to profound sensorineural hearing loss (‘single-sided deafness’) (2021)
Journal Article
Katiri, R., Hall, D. A., Killan, C. F., Smith, S., Prayuenyong, P., & Kitterick, P. T. (2021). Systematic review of outcome domains and instruments used in designs of clinical trials for interventions that seek to restore bilateral and binaural hearing in adults with unilateral severe to profound sensorineural hearing loss (‘single-sided deafness’). Trials, 22, Article 220. https://doi.org/10.1186/s13063-021-05160-5

Background: This systematic review aimed to identify, compare and contrast outcome domains and outcome instruments reported in studies investigating interventions that seek to restore bilateral (two-sided) and/or binaural (both ears) hearing in adult... Read More about Systematic review of outcome domains and instruments used in designs of clinical trials for interventions that seek to restore bilateral and binaural hearing in adults with unilateral severe to profound sensorineural hearing loss (‘single-sided deafness’).

Evidence for biological markers of tinnitus: A systematic review (2021)
Book Chapter
Haider, H. F., Hoare, D. J., Ribeiro, S. F., Ribeiro, D., Caria, H., Trigueiros, N., …Sereda, M. (2021). Evidence for biological markers of tinnitus: A systematic review. In Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards understanding the complexity of tinnitus (345-398). Elsevier. https://doi.org/10.1016/bs.pbr.2021.01.022

Subjective tinnitus is a phantom sound heard only by the affected person and may be a symptom of various diseases. Tinnitus diagnosis and monitoring is based on subjective audiometric and psychometric methods. This review aimed to synthesize evidence... Read More about Evidence for biological markers of tinnitus: A systematic review.

Redesigning a web-based stakeholder consensus meeting about core outcomes for clinical trials: Formative feedback study (2021)
Working Paper
Katiri, R., Hall, D. A., Hoare, D. J., Fackrell, K., Horobin, A., Buggy, N., …Core Rehabilitation Outcome Set For Single-Sided Deafness (CROSSSD) Initiative, . Redesigning a web-based stakeholder consensus meeting about core outcomes for clinical trials: Formative feedback study

Background: Clinical trials that assess the benefits and harms of an intervention do so by measuring and reporting outcomes. Inconsistent selection and diversity in the choice of outcomes makes it challenging to directly compare interventions. To... Read More about Redesigning a web-based stakeholder consensus meeting about core outcomes for clinical trials: Formative feedback study.

Real-world experience of using ciclosporin-A 0.1% (Ikervis) in the management of ocular surface inflammatory diseases (2021)
Journal Article
Deshmukh, R., Ting, D. S. J., Elsahn, A., Mohammed, I., Said, D. G., & Dua, H. S. (2022). Real-world experience of using ciclosporin-A 0.1% (Ikervis) in the management of ocular surface inflammatory diseases. British Journal of Ophthalmology, 106(8), 1087-1092. https://doi.org/10.1136/bjophthalmol-2020-317907

Purpose: To report the real-world experience of using topical ciclosporin, Ikervis, in the management of ocular surface inflammatory diseases (OSIDs). Methods: This was a retrospective study of patients treated with Ikervis for OSIDs at the Queen’... Read More about Real-world experience of using ciclosporin-A 0.1% (Ikervis) in the management of ocular surface inflammatory diseases.

Ventilation strategies for front of neck airway rescue: an in silico study (2021)
Journal Article
Laviola, M., Niklas, C., Das, A., Bates, D. G., & Hardman, J. G. (2021). Ventilation strategies for front of neck airway rescue: an in silico study. British Journal of Anaesthesia, 126(6), 1226-1236. https://doi.org/10.1016/j.bja.2021.01.030

Background. During induction of general anaesthesia a “can’t intubate, can’t oxygenate” (CICO) situation can arise, leading to severe hypoxaemia. Evidence is scarce to guide ventilation strategies for small-bore front of neck airways that ensure effe... Read More about Ventilation strategies for front of neck airway rescue: an in silico study.

Operculo-Insular and Anterior Cingulate Plasticity Induced by Transcranial Magnetic Stimulation in the Human Motor Cortex: A Dynamic Casual Modelling Study (2021)
Journal Article
Hodkinson, D. J., Bungert, A., Bowtell, R. W., Jackson, S. R., & Jung, J. (2021). Operculo-Insular and Anterior Cingulate Plasticity Induced by Transcranial Magnetic Stimulation in the Human Motor Cortex: A Dynamic Casual Modelling Study. Journal of Neurophysiology, 125(4), 1180-1190. https://doi.org/10.1152/jn.00670.2020

The ability to induce neuroplasticity with non-invasive brain stimulation techniques offers a unique opportunity to examine the human brain systems involved in pain modulation. In experimental and clinical settings, the primary motor cortex (M1) is c... Read More about Operculo-Insular and Anterior Cingulate Plasticity Induced by Transcranial Magnetic Stimulation in the Human Motor Cortex: A Dynamic Casual Modelling Study.

Outcomes in Antiplatelet?Associated Intracerebral Hemorrhage in the TICH?2 Randomized Controlled Trial (2021)
Journal Article
Law, Z. K., Desborough, M., Roberts, I., Al‐Shahi Salman, R., England, T. J., Werring, D. J., …Sprigg, N. (2021). Outcomes in Antiplatelet‐Associated Intracerebral Hemorrhage in the TICH‐2 Randomized Controlled Trial. Journal of the American Heart Association, 10(5), Article e019130. https://doi.org/10.1161/jaha.120.019130

Background Antiplatelet therapy increases the risk of hematoma expansion in intracerebral hemorrhage (ICH) while the effect on functional outcome is uncertain. Methods and Results This is an exploratory analysis of the TICH‐2 (Tranexamic Acid in... Read More about Outcomes in Antiplatelet?Associated Intracerebral Hemorrhage in the TICH?2 Randomized Controlled Trial.

Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation (2021)
Journal Article
Stolady, D., Laviola, M., Pillai, A., & Hardman, J. G. (2021). Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation. British Journal of Anaesthesia, 126(4), 889-895. https://doi.org/10.1016/j.bja.2020.12.031

Background Studies of pulmonary denitrogenation (pre-oxygenation) in obstetric populations have shown high flow nasal oxygen therapy (HFNO) is inferior to facemask techniques. HFNO achieves median end-tidal oxygen fraction (FE′O2) of 0.87 after 3... Read More about Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation.

Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres (2021)
Journal Article
Wallace, M. N., Sumner, C. J., Berger, J. I., McNaughton, P. A., & Palmer, A. R. (2021). Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres. Neuroscience Letters, 747, Article 135705. https://doi.org/10.1016/j.neulet.2021.135705

Tinnitus has similarities to chronic neuropathic pain where there are changes in the firing rate of different types of afferent neurons. We postulated that one possible cause of tinnitus is a change in the distribution of spontaneous firing rates in... Read More about Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres.

Tinnitus and Tinnitus Disorder: Theoretical and Operational Definitions (An international multidisciplinary proposal) (2021)
Book Chapter
De Ridder, D., Schlee, W., Vanneste, S., Londero, A., Weisz, N., Kleinjung, T., …Langguth, B. (2021). Tinnitus and Tinnitus Disorder: Theoretical and Operational Definitions (An international multidisciplinary proposal). . Elsevier. https://doi.org/10.1016/bs.pbr.2020.12.002

As for hypertension, chronic pain, epilepsy and other disorders with particular symptoms, a commonly accepted and unambiguous definition provides a common ground for researchers and clinicians to study and treat the problem. The WHO's ICD11 definitio... Read More about Tinnitus and Tinnitus Disorder: Theoretical and Operational Definitions (An international multidisciplinary proposal).

Hearing Aids Reduce Daily-Life Fatigue and Increase Social Activity: A Longitudinal Study (2021)
Journal Article
Holman, J. A., Drummond, A., & Naylor, G. (2021). Hearing Aids Reduce Daily-Life Fatigue and Increase Social Activity: A Longitudinal Study. Trends in Hearing, 25, https://doi.org/10.1177/23312165211052786

People with hearing loss experience fatigue, and it is unknown whether this is alleviated by treatment with hearing aids. The objective of this study was to address this issue and to investigate the possible concomitant effect of hearing-aid fitting... Read More about Hearing Aids Reduce Daily-Life Fatigue and Increase Social Activity: A Longitudinal Study.

The prevalence of tinnitus in China: a systematic review of the literature (2021)
Journal Article
Dawei, Z., Xu, Q., Caimino, C., & Baguley, D. M. (2021). The prevalence of tinnitus in China: a systematic review of the literature. Journal of Laryngology and Otology, 135(1), 3-9. https://doi.org/10.1017/S002221512000256X

Purpose: The aim of the present study was to identify reports of the prevalence of tinnitus in China and to present these findings in a review format. Method: We assessed and collated published prevalence estimates of tinnitus and tinnitus severity,... Read More about The prevalence of tinnitus in China: a systematic review of the literature.

Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA) (2021)
Journal Article
Ní Leidhin, C., McMorrow, J., Carey, D., Newman, L., Williamson, W., Fagan, A. J., …Knight, S. P. (2021). Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA). NeuroImage, 229, Article 117741. https://doi.org/10.1016/j.neuroimage.2021.117741

Objective To establish normative reference values for total grey matter cerebral blood flow (CBFGM) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged 54 years and older. Backgroun... Read More about Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA).