Evidence for biological markers of tinnitus: A systematic review

Haider, Haúla F.; Hoare, Derek J.; Ribeiro, Sara F.; Ribeiro, Diogo; Caria, Helena; Trigueiros, Nuno; Borrego, Luís Miguel; Szczepek, Agnieszka J.; Papoila, Ana Luísa; Elarbed, Asma; da Luz Martins, Maria; Paço, João; Sereda, Magdalena

Abstract

Subjective tinnitus is a phantom sound heard only by the affected person and may be a symptom of various diseases. Tinnitus diagnosis and monitoring is based on subjective audiometric and psychometric methods. This review aimed to synthesize evidence for tinnitus presence or its severity. We searched several electronic databases, citation searches of the included primary studies through Web of Science, and further hand searches. At least two authors performed all systematic review steps. Sixty-two records were included and were categorized according the biological variable. Evidence for possible tinnitus biomarkers come from oxidative stress, interleukins, steroids and neurotransmitters categories. We found conflicting evidence for full blood count, vitamins, lipid profile, neurotrophic factors, or inorganic ions. There was no evidence for an association between tinnitus and the remaining categories. The current review evidences that larger studies, with stricter exclusion criteria and powerful harmonized methodological design are needed. Protocol published on PROSPERO (CRD42017070998).

Citation

Haider, H. F., Hoare, D. J., Ribeiro, S. F., Ribeiro, D., Caria, H., Trigueiros, N., Borrego, L. M., Szczepek, A. J., Papoila, A. L., Elarbed, A., da Luz Martins, M., Paço, J., & Sereda, M. (2021). Evidence for biological markers of tinnitus: A systematic review. In Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards understanding the complexity of tinnitus (345-398). Elsevier. https://doi.org/10.1016/bs.pbr.2021.01.022

• Online Publication Date: Mar 19, 2021
• Publication Date: 2021
• Deposit Date: Jul 22, 2021
• Publisher: Elsevier
• Pages: 345-398
• Series Title: Progress in Brain Research
• Series Number: 262
• Series ISSN: 0079-6123
• Book Title: Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards understanding the complexity of tinnitus
• Chapter Number: 17
• ISBN: 9780128223758
• DOI: https://doi.org/10.1016/bs.pbr.2021.01.022
• Public URL: https://nottingham-repository.worktribe.com/output/5815114