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Evidence for biological markers of tinnitus: A systematic review

Haider, Haúla F.; Hoare, Derek J.; Ribeiro, Sara F.; Ribeiro, Diogo; Caria, Helena; Trigueiros, Nuno; Borrego, Luís Miguel; Szczepek, Agnieszka J.; Papoila, Ana Luísa; Elarbed, Asma; da Luz Martins, Maria; Paço, João; Sereda, Magdalena

Authors

Haúla F. Haider

DEREK HOARE derek.hoare@nottingham.ac.uk
Associate Professor in Hearing Sciences

Sara F. Ribeiro

Diogo Ribeiro

Helena Caria

Nuno Trigueiros

Luís Miguel Borrego

Agnieszka J. Szczepek

Ana Luísa Papoila

Asma Elarbed

Maria da Luz Martins

João Paço



Abstract

Subjective tinnitus is a phantom sound heard only by the affected person and may be a symptom of various diseases. Tinnitus diagnosis and monitoring is based on subjective audiometric and psychometric methods. This review aimed to synthesize evidence for tinnitus presence or its severity. We searched several electronic databases, citation searches of the included primary studies through Web of Science, and further hand searches. At least two authors performed all systematic review steps. Sixty-two records were included and were categorized according the biological variable. Evidence for possible tinnitus biomarkers come from oxidative stress, interleukins, steroids and neurotransmitters categories. We found conflicting evidence for full blood count, vitamins, lipid profile, neurotrophic factors, or inorganic ions. There was no evidence for an association between tinnitus and the remaining categories. The current review evidences that larger studies, with stricter exclusion criteria and powerful harmonized methodological design are needed. Protocol published on PROSPERO (CRD42017070998).

Citation

Haider, H. F., Hoare, D. J., Ribeiro, S. F., Ribeiro, D., Caria, H., Trigueiros, N., …Sereda, M. (2021). Evidence for biological markers of tinnitus: A systematic review. In Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards understanding the complexity of tinnitus (345-398). Elsevier. https://doi.org/10.1016/bs.pbr.2021.01.022

Online Publication Date Mar 19, 2021
Publication Date 2021
Deposit Date Jul 22, 2021
Publisher Elsevier
Pages 345-398
Series Title Progress in Brain Research
Series Number 262
Series ISSN 0079-6123
Book Title Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards understanding the complexity of tinnitus
Chapter Number 17
ISBN 9780128223758
DOI https://doi.org/10.1016/bs.pbr.2021.01.022
Public URL https://nottingham-repository.worktribe.com/output/5815114