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All Outputs (58)

Accumulation of Brain Hypointense Foci on Susceptibility-Weighted Imaging in Childhood Ataxia Telangiectasia (2021)
Journal Article
Dineen, R. A., Blanchard, C. C., Pszczolkowski, S., Paine, S., Prasad, M., Chow, G., …Auer, D. P. (2021). Accumulation of Brain Hypointense Foci on Susceptibility-Weighted Imaging in Childhood Ataxia Telangiectasia. American Journal of Neuroradiology, 42(6), 1144-1150. https://doi.org/10.3174/ajnr.a7107

Background and Purpose Susceptibility-weighted imaging (SWI) hypointense cerebral lesions have been reported in adults with the inherited cerebellar neurodegenerative disorder ataxia telangiectasia (A-T). This study aims to establish the prevalence... Read More about Accumulation of Brain Hypointense Foci on Susceptibility-Weighted Imaging in Childhood Ataxia Telangiectasia.

Airflow dispersion during common neonatal resuscitation procedures: A simulation study (2021)
Journal Article
Kwok, T. C., Swaby, R., & Sharkey, D. (2021). Airflow dispersion during common neonatal resuscitation procedures: A simulation study. Pediatric Pulmonology, 56(7), 2057-2066. https://doi.org/10.1002/ppul.25378

Background Aerosol generating medical procedures (AGMPs) are common during newborn resuscitation. Neonates with respiratory viruses such as severe acute respiratory syndrome coronavirus 2 (SARS?CoV?2) infection may pose a risk to healthcare workers.... Read More about Airflow dispersion during common neonatal resuscitation procedures: A simulation study.

Evaluating the influence of progesterone concentration and time of exposure on in vitro endometrial decidualisation (2021)
Journal Article
Suthaporn, S., Jayaprakasan, K., Thornton, J. G., Walker, K. F., Castellanos, M., May, S., …Maalouf, W. E. (2021). Evaluating the influence of progesterone concentration and time of exposure on in vitro endometrial decidualisation. Molecular and Cellular Endocrinology, 528, Article 111242. https://doi.org/10.1016/j.mce.2021.111242

This study aimed to evaluate the influence of progesterone (concentration and time of exposure) on endometrial decidualisation using an in vitro model cell line: Human Endometrial Stromal Cells (HESCs). HESCs exposed to progesterone (1 and 10 μM) had... Read More about Evaluating the influence of progesterone concentration and time of exposure on in vitro endometrial decidualisation.

Outcomes for children with acquired brain injury (ABI) admitted to acute neurorehabilitation (2021)
Journal Article
Keetley, R., Bennett, E., Williams, J., Stewart, I., Whitehouse, W., Pilling, P., & Manning, J. (2021). Outcomes for children with acquired brain injury (ABI) admitted to acute neurorehabilitation. Developmental Medicine and Child Neurology, 63(7), 824-830. https://doi.org/10.1111/dmcn.14846

Aim: To evaluate an innovative paediatric neurorehabilitation model in relation to improving quality of neurorehabilitation and reducing length of stay (LOS). Method: Process evaluation approach was conducted in line with Medical Research Council... Read More about Outcomes for children with acquired brain injury (ABI) admitted to acute neurorehabilitation.

Outcomes for children with acquired brain injury (ABI) admitted to acute neurorehabilitation (2021)
Journal Article
Keetley, R., Bennett, E., Williams, J., Stewart, I., Whitehouse, W. P., Pilling, P., & Manning, J. C. (2021). Outcomes for children with acquired brain injury (ABI) admitted to acute neurorehabilitation. Developmental Medicine and Child Neurology, https://doi.org/10.1111/dmcn.14846

Aim: To evaluate an innovative paediatric neurorehabilitation model in relation to improving quality of neurorehabilitation and reducing length of stay (LOS) for children with acquired brain injury. Method: A process evaluation approach was cond... Read More about Outcomes for children with acquired brain injury (ABI) admitted to acute neurorehabilitation.

Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study (2021)
Journal Article
Shipley, L., Gale, C., & Sharkey, D. (2021). Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study. Archives of Disease in Childhood. Fetal and Neonatal Edition, 106(5), https://doi.org/10.1136/archdischild-2020-320902

Objective: Hypoxic-ischaemic encephalopathy (HIE) remains a leading cause of neonatal mortality and neurodisability. We aimed to determine the incidence of HIE and management patterns against national guidelines. Design: Retrospective cohort study... Read More about Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study.

Integrative molecular characterization of pediatric spinal ependymoma: the UK Children’s Cancer and Leukaemia Group study (2021)
Journal Article
Ahmad, O., Chapman, R., Storer, L. C., Luo, L., Heath, P. R., Resar, L., …Lourdusamy, A. (2021). Integrative molecular characterization of pediatric spinal ependymoma: the UK Children’s Cancer and Leukaemia Group study. Neuro-Oncology Advances, 3(1), 1-13. https://doi.org/10.1093/noajnl/vdab043

Background Pediatric spinal ependymomas (SP-EPNs) are rare primary central nervous system tumors with heterogeneous clinical course. Considering that ependymomas in children are biologically distinct from their adult counterparts, this study aimed t... Read More about Integrative molecular characterization of pediatric spinal ependymoma: the UK Children’s Cancer and Leukaemia Group study.

3D spheroid models of paediatric SHH medulloblastoma mimic tumour biology, drug response and metastatic dissemination (2021)
Journal Article
Roper, S. J., Linke, F., Scotting, P. J., & Coyle, B. (2021). 3D spheroid models of paediatric SHH medulloblastoma mimic tumour biology, drug response and metastatic dissemination. Scientific Reports, 11(1), Article 4259. https://doi.org/10.1038/s41598-021-83809-6

© 2021, The Author(s). Studying medulloblastoma, the most common malignant paediatric brain tumour, requires simple yet realistic in vitro models. In this study, we optimised a robust, reliable, three-dimensional (3D) culture method for medulloblasto... Read More about 3D spheroid models of paediatric SHH medulloblastoma mimic tumour biology, drug response and metastatic dissemination.

Lipid traffic analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism (2021)
Journal Article
Furse, S., Watkins, A., Hojat, N., Smith, J., Williams, H., Chiarugi, D., & Koulman, A. (2021). Lipid traffic analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism. Communications Biology, 4, Article 163. https://doi.org/10.1038/s42003-021-01686-1

In this paper we present an investigation of parental-diet-driven metabolic programming in offspring using a novel computational network analysis tool. The impact of high paternal carbohydrate intake on offsprings’ phospholipid and triglyceride metab... Read More about Lipid traffic analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism.

Polymer pro-drug nanoparticles for sustained release of cytotoxic drugs evaluated in patient-derived glioblastoma cell lines and in situ gelling formulations (2021)
Journal Article
Vasey, C. E., Cavanagh, R. J., Taresco, V., Moloney, C., Smith, S., Rahman, R., & Alexander, C. (2021). Polymer pro-drug nanoparticles for sustained release of cytotoxic drugs evaluated in patient-derived glioblastoma cell lines and in situ gelling formulations. Pharmaceutics, 13(2), https://doi.org/10.3390/pharmaceutics13020208

Glioblastoma (GBM) is the most common, malignant and aggressive brain tumour in adults. Despite the use of multimodal treatments, involving surgery, followed by concomitant radiotherapy and chemotherapy, the median survival for patients remains less... Read More about Polymer pro-drug nanoparticles for sustained release of cytotoxic drugs evaluated in patient-derived glioblastoma cell lines and in situ gelling formulations.

CovidNeuroOnc: a UK multi-centre, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service (2021)
Journal Article
Fountain, D. M., Piper, R. J., Poon, M. T. C., Solomou, G., Brennan, P. M., Chowdhury, Y. A., …Jenkinson, M. D. (2021). CovidNeuroOnc: a UK multi-centre, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service. Neuro-Oncology Advances, 3(1), Article vdab014. https://doi.org/10.1093/noajnl/vdab014

Background: The COVID-19 pandemic has profoundly affected cancer services. Our objective was to determine the effect of the COVID-19 pandemic on decision making and the resulting outcomes for patients with newly diagnosed or recurrent intracranial tu... Read More about CovidNeuroOnc: a UK multi-centre, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service.

Smartphone monitoring of in-ambulance vibration and noise (2021)
Journal Article
Partridge, T., Gherman, L., Morris, D., Light, R., Leslie, A., Sharkey, D., …Crowe, J. (2021). Smartphone monitoring of in-ambulance vibration and noise. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 235(4), 428-436. https://doi.org/10.1177/0954411920985994

Transferring sick premature infants between hospitals increases the risk of severe brain injury, potentially linked to the excessive exposure to noise, vibration and driving-related accelerations. One method of reducing these levels may be to travel... Read More about Smartphone monitoring of in-ambulance vibration and noise.

The challenges of randomised control trials in obstetrics and gynaecology (2021)
Journal Article
Harper, S. L., Thornton, J. G., & Walker, K. F. (2021). The challenges of randomised control trials in obstetrics and gynaecology. Obstetrics, Gynaecology and Reproductive Medicine, 31(2), 59-60. https://doi.org/10.1016/j.ogrm.2020.12.006

In this short article we explore some of the challenges faced by those conducting randomised trials in obstetrics and gynaecology. We discuss the current status of trials comparing induction of labour versus expectant management, so called ‘deliver o... Read More about The challenges of randomised control trials in obstetrics and gynaecology.

Assessment of Cannabidiol and ?9-Tetrahydrocannabiol in Mouse Models of Medulloblastoma and Ependymoma (2021)
Journal Article
Andradas, C., Byrne, J., Kuchibhotla, M., Ancliffe, M., Jones, A. C., Carline, B., …Endersby, R. (2021). Assessment of Cannabidiol and ∆9-Tetrahydrocannabiol in Mouse Models of Medulloblastoma and Ependymoma. Cancers, 13, Article 330. https://doi.org/10.3390/cancers13020330

Children with medulloblastoma and ependymoma are treated with a multidisciplinary approach that incorporates surgery, radiotherapy, and chemotherapy; however, overall survival rates for patients with high-risk disease remain unsatisfactory. Data indi... Read More about Assessment of Cannabidiol and ?9-Tetrahydrocannabiol in Mouse Models of Medulloblastoma and Ependymoma.

ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma (2021)
Journal Article
Nasir, A., Cardall, A., Othman, R. T., Nicolaou, N., Lourdusamy, A., Linke, F., …Coyle, B. (2021). ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma. Neuro-Oncology Advances, 3(1), https://doi.org/10.1093/noajnl/vdab030

Background: Therapeutic intervention in metastatic medulloblastoma is dependent upon elucidating the underlying metastatic mechanism. We investigated whether an epithelialmesenchymal transition (EMT)-like pathway could drive medulloblastoma metastasi... Read More about ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma.