All Outputs (10)

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study (2018)
Journal Article
Shrine, N., Portelli, M. A., John, C., Soler Artigas, M., Bennett, N., Hall, R., …Sayers, I. (2019). Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. Lancet Respiratory Medicine, 7(1), 20-34. https://doi.org/10.1016/S2213-2600%2818%2930389-8

Background Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types of asthma contribut... Read More about Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

MMP-1 activation contributes to airway smooth muscle growth and asthma severity (2016)
Journal Article
Naveed, S., Clements, D., Jackson, D. J., Philp, C., Billington, C. K., Soomro, I. N., …Johnson, S. R. (2017). MMP-1 activation contributes to airway smooth muscle growth and asthma severity. American Journal of Respiratory and Critical Care Medicine, 195(8), 1000-1009. https://doi.org/10.1164/rccm.201604-0822OC

Introduction: Matrix metalloproteinase-1 and mast cells are present in the airways of people with asthma. We hypothesised that matrix metalloproteinase-1 could be activated by mast cells and increase asthma severity. Methods: Patients with stable ast... Read More about MMP-1 activation contributes to airway smooth muscle growth and asthma severity.

Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study (2016)
Journal Article
Wilson, S. J., Ward, J. A., Sousa, A. R., Corfield, J., Bansal, A. T., De Meulder, B., …Howarth, P. H. (in press). Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study. European Respiratory Journal, 48(5), 1307-1319. https://doi.org/10.1183/13993003.01129-2016

The U-BIOPRED study is a multicentre European study aimed at a better understanding of severe asthma. It included three steroid-treated adult asthma groups (severe nonsmokers (SAn group), severe current/ex-smokers (SAs/ex group) and those with mild–m... Read More about Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study.

The utility of exhaled nitric oxide in patients with suspected asthma (2016)
Journal Article
Martin, M., Wilson, E., Gerrard-Tarpey, W., Meakin, G., Hearson, G., McKeever, T., …Harrison, T. (2016). The utility of exhaled nitric oxide in patients with suspected asthma. Thorax, 71(6), https://doi.org/10.1136/thoraxjnl-2015-208014

The value of FENO measurements in patients with symptoms suggestive of asthma is unclear. We performed an observational study to assess the ability of FENO to diagnose asthma and to predict response to inhaled corticosteroids (ICS). Our findings sugg... Read More about The utility of exhaled nitric oxide in patients with suspected asthma.

The effects of azithromycin in treatment-resistant cough: A randomized, double-blind, placebo-controlled trial (2016)
Journal Article
Hodgson, D., Anderson, J., Reynolds, C., Oborne, J., Meakin, G., Bailey, H., …Harrison, T. (2016). The effects of azithromycin in treatment-resistant cough: A randomized, double-blind, placebo-controlled trial. Chest, 149(4), 1052-1060. https://doi.org/10.1016/j.chest.2015.12.036

Background Chronic cough is a common clinical problem worldwide. Although many patients have underlying precipitating conditions such as asthma, gastroesophageal reflux, or rhinitis, many remain symptomatic despite treating these conditions. New a... Read More about The effects of azithromycin in treatment-resistant cough: A randomized, double-blind, placebo-controlled trial.

Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma (2015)
Journal Article
Lilburn, D. M., Tatler, A. L., Six, J. S., Lesbats, C., Habgood, A., Porte, J., …Meersmann, T. (2015). Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma. Magnetic Resonance in Medicine, 76(4), 1224-1235. https://doi.org/10.1002/mrm.26003

© 2015 The Authors. Wiley Periodicals, Inc. Purpose: Asthma is a disease of increasing worldwide importance that calls for new investigative methods. Ex vivo lung tissue is being increasingly used to study functional respiratory parameters independen... Read More about Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma.

Building analytic skills to drive improvements in patient care and organisational decision making: an information analysts’ development programme (2015)
Journal Article
Howard, G., Walker, A. J., Shaw, D. E., & Hatton, J. W. (2015). Building analytic skills to drive improvements in patient care and organisational decision making: an information analysts’ development programme. Clinical Governance, 20(3), https://doi.org/10.1108/CGIJ-07-2015-0021

Purpose This paper briefly outlines a development programme designed to improve the skills of NHS Information Analysts and assesses the extent these skills have been developed. There are significant opportunities for the NHS to utilise information... Read More about Building analytic skills to drive improvements in patient care and organisational decision making: an information analysts’ development programme.

The burden of severe asthma in childhood and adolescence: Results from the paediatric U-BIOPRED cohorts (2015)
Journal Article
Fleming, L., Murray, C., Bansal, A. T., Hashimoto, S., Bisgaard, H., Bush, A., …Roberts, G. (2015). The burden of severe asthma in childhood and adolescence: Results from the paediatric U-BIOPRED cohorts. European Respiratory Journal, 46(5), https://doi.org/10.1183/13993003.00780-2015

U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional and innovative systems biology approaches. A total of 99 school-age children with severe asthma and 81 preschoolers with severe wheeze were compared with 49 schoo... Read More about The burden of severe asthma in childhood and adolescence: Results from the paediatric U-BIOPRED cohorts.

Navigating in large hospitals (2015)
Conference Proceeding
Hughes, N., Pinchin, J., Brown, M., & Shaw, D. E. (in press). Navigating in large hospitals.

Navigating around large hospitals can be a stressful and time-consuming experience for all users of the hospital infrastructure. Navigation difficulties encountered by patients and visitors can result in missed appointments or simply create a poor im... Read More about Navigating in large hospitals.

Off-line breath acetone analysis in critical illness (2013)
Journal Article
Sturney, S. C., Storer, M., Shaw, D. E., & Epton, M. (2013). Off-line breath acetone analysis in critical illness. Journal of Breath Research, 7(3), https://doi.org/10.1088/1752-7155/7/3/037102

Analysis of breath acetone could be useful in the Intensive Care Unit (ICU) setting to monitor evidence of starvation and metabolic stress. The aims of this study were to examine the relationship between acetone concentrations in breath and blood in... Read More about Off-line breath acetone analysis in critical illness.