All Outputs (817)

Who applies and who gets admitted to UK graduate entry medicine?: an analysis of UK admission statistics (2011)
Journal Article

Background Graduate-entry medicine is a recent development in the UK, intended to expand and broaden access to medical training. After eight years, it is time to evaluate its success in recruitment. Objectives This study aimed to compare th... Read More about Who applies and who gets admitted to UK graduate entry medicine?: an analysis of UK admission statistics.

Delayed publications of clinical trials in cystic fibrosis (2011)
Journal Article

Background: When the publication of important trial data is delayed, or data are never published, this will prevent the proper practice of evidence based medicine through robust systematic reviews. Clinical trial registries allow researchers to... Read More about Delayed publications of clinical trials in cystic fibrosis.

Maternal nutrient restriction during late gestation and early postnatal growth in sheep differentially reset the control of energy metabolism in the gastric mucosa (2011)
Journal Article

Fetal growth restriction followed by accelerated postnatal growth contributes to impaired metabolic function in adulthood. The extent to which these outcomes may be mediated centrally within the hypothalamus, as opposed to in the periphery within the... Read More about Maternal nutrient restriction during late gestation and early postnatal growth in sheep differentially reset the control of energy metabolism in the gastric mucosa.

Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration (2010)
Journal Article

The significance of the accumulation of ubiquitin-positive intraneuronal inclusions in the brains of those affected with different neurodegenerative diseases is currently unclear. While one interpretation is that the disease mechanism(s) involves dys... Read More about Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration.

A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients (2010)
Journal Article

Single clustering methods have often been used to elucidate clusters in high dimensional medical data, even though reliance on a single algorithm is known to be problematic. In this paper, we present a methodology to determine a set of ‘core classes’... Read More about A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients.

A qualitative investigation into the rehabilitation experience of patients following wrist fracture (2010)
Journal Article

Introduction. Fractures of the wrist are often highly traumatic, leading to significant pain and reduction in an individual’s home, work and leisure roles for a considerable time. Among the studies on wrist fracture, there is limited evidence which... Read More about A qualitative investigation into the rehabilitation experience of patients following wrist fracture.

Using the CLOX drawing task to educate the public of the effects of hearing loss (2010)
Journal Article

We describe a task used to educate the public on the importance of hearing and the experience of hearing loss. During an open day at Nottingham University, participants were presented with verbal instructions (with or without a background masker) and... Read More about Using the CLOX drawing task to educate the public of the effects of hearing loss.

Prospective metanalysis within complementary medicine research (2010)
Journal Article

Comparative attainment of 5-year undergraduate and 4-year graduate entry medical students moving into foundation training (2009)
Journal Article

Background Graduate entry medicine is a recent innovation in UK medical training. Evidence is sparse at present as to progress and attainment on these programmes. Shared clinical rotations, between an established 5-year and a new graduate entry co... Read More about Comparative attainment of 5-year undergraduate and 4-year graduate entry medical students moving into foundation training.

Systematic review and meta-analysis of interventions relevant for young offenders with mood disorders, anxiety disorders, or self-harm (2009)
Journal Article

Background: Mood and anxiety disorders, and problems with self harm are significant and serious issues that are common in young people in the Criminal Justice System. Aims: To examine whether interventions relevant to young offenders with mood or an... Read More about Systematic review and meta-analysis of interventions relevant for young offenders with mood disorders, anxiety disorders, or self-harm.

Risk assessment and lipid modification for primary and secondary prevention of cardiovascular disease: summary of NICE guidance (2008)
Journal Article

Effectiveness of memory rehabilitation after stroke (2008)
Journal Article

Cognitive rehabilitation for memory deficits following stroke (2007)
Journal Article

Background: Memory problems are a common cognitive complaint following stroke. Memory rehabilitation programmes either attempt to retrain lost or poor memory functions, or teach patients strategies to cope with them. Objectives: To determi... Read More about Cognitive rehabilitation for memory deficits following stroke.

Established corticosteroid creams should be applied only once daily in patients with atopic eczema (2007)
Journal Article

Atopic eczema affects many adults and up to 20% of children,1 with health costs comparable to diabetes2 and asthma.3 One community survey of 1760 young children in the United Kingdom found that 84% had mild eczema, 14% moderate, and 2% severe eczema.... Read More about Established corticosteroid creams should be applied only once daily in patients with atopic eczema.

Should eye protection be worn during dermatological surgery: prospective observational study (2007)
Journal Article

Background There is a potential risk of infection with blood-borne viruses if a doctor receives a blood splash to a mucous membrane. The quantification of facial contamination with blood has never been documented in the context of dermatological sur... Read More about Should eye protection be worn during dermatological surgery: prospective observational study.

Feasibility study to inform the design of a UK multi-centre randomised controlled trial of prophylactic antibiotics for the prevention of recurrent cellulitis of the leg (2007)
Journal Article

Background: This paper describes the results of a feasibility study for a randomised controlled trial (RCT). Methods: Twenty-nine members of the UK Dermatology Clinical Trials Network (UK DCTN) expressed an interest in recruiting for this study.... Read More about Feasibility study to inform the design of a UK multi-centre randomised controlled trial of prophylactic antibiotics for the prevention of recurrent cellulitis of the leg.

Early allergen exposure and atopic eczema (2007)
Journal Article

Background The relationship between exposure to indoor aeroallergens in early life and subsequent eczema is unclear. We have previously failed to show any significant associations between early life exposure to house dust mite and cat fur allergen... Read More about Early allergen exposure and atopic eczema.

How epidemiology has challenged 3 prevailing concepts about atopic dermatitis (2006)
Journal Article

We challenge 3 prevailing concepts in understanding atopic dermatitis using data from epidemiologic studies. First, we show that although atopy is associated with atopic dermatitis to some degree, its importance is not likely to be a simple causea... Read More about How epidemiology has challenged 3 prevailing concepts about atopic dermatitis.

Effectiveness and cost-effectiveness of salicylic acid and cryotherapy for cutaneous warts: an economic decision model (2006)
Book

Objectives: To estimate the costs of commonly used treatments for cutaneous warts, as well as their health benefits and risk. To create an economic decision model to evaluate the cost-effectiveness of these treatments, and, as a result, assess whethe... Read More about Effectiveness and cost-effectiveness of salicylic acid and cryotherapy for cutaneous warts: an economic decision model.

Total loss of MHC class I is an independent indicator of good prognosis in breast cancer (2005)
Journal Article

Tumours can be recognised by CTL and NK cells. CTL recognition depends on expression of MHC Class I loaded with peptides from tumour antigens. In contrast, loss of MHC Class I results in NK activation. In our study a large set of samples from patient... Read More about Total loss of MHC class I is an independent indicator of good prognosis in breast cancer.