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Delayed publications of clinical trials in cystic fibrosis

Hurley, M.N.; Prayle, A.P.; Smyth, Alan R.

Authors

M.N. Hurley

A.P. Prayle

Alan R. Smyth



Abstract

Background:

When the publication of important trial data is delayed, or data are never published, this will prevent the proper practice of evidence based medicine through robust systematic reviews. Clinical trial registries allow researchers to interrogate the trial protocol and afford the opportunity to identify studies that have been completed and so determine the time lag between completion and publication.

Methods:

We searched ClinicalTrials.gov with the keywords ‘cystic fibrosis’. Intervention trials which had completed 1st Jan 1998–31st Dec 2010 were selected. Time to publication in a peer-reviewed journal was calculated. Survival analyses using the log rank test were undertaken.

Results:

We identified 142 records. Of these, 62 had full paper publications. The median time to publication was 3.25 years. Phase of study (phase one studies more delayed, p = 0.024) but not source of funding (p = 0.34) was associated with time to publication.

Conclusions:

Clinical trials in cystic fibrosis take a considerable amount of time to report their findings. More importantly, a large number of trials fail to report at all.

Journal Article Type Article
Publication Date Sep 1, 2011
Journal Journal of Cystic Fibrosis
Print ISSN 1569-1993
Electronic ISSN 1873-5010
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 11
Issue 1
Institution Citation Hurley, M., Prayle, A., & Smyth, A. R. (2011). Delayed publications of clinical trials in cystic fibrosis. Journal of Cystic Fibrosis, 11(1), doi:10.1016/j.jcf.2011.08.004
DOI https://doi.org/10.1016/j.jcf.2011.08.004
Keywords Cystic fibrosis, Publication bias, Clinical trials
Publisher URL http://www.sciencedirect.com/science/article/pii/S1569199311001378#
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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