All Outputs (105)

"They don't see it as priority if the kid's not sporty": parents' perceptions of clinic communication around physical activity to children with type 1 diabetes and their families (2018)
Journal Article

Background: The aim of the study was to understand parent’s perceptions of the way in which information about physical activity (PA) is communicated to families by healthcare professionals, and gather their views on the use of digital resources for p... Read More about "They don't see it as priority if the kid's not sporty": parents' perceptions of clinic communication around physical activity to children with type 1 diabetes and their families.

Beauty is in the eye of the beholder: the appraisal of facial attractiveness and its relation to conscious awareness (2018)
Journal Article

Previous research suggests that facial attractiveness relies on features such as symmetry, averageness and above-average sexual dimorphic characteristics. Due to the evolutionary and sociobiological value of these characteristics, it has been suggest... Read More about Beauty is in the eye of the beholder: the appraisal of facial attractiveness and its relation to conscious awareness.

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study (2018)
Journal Article

Background Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types of asthma contribut... Read More about Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Visual inspection for diagnosing cutaneous melanoma in adults (2018)
Journal Article

Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. History-taking and visual inspection of a suspicious... Read More about Visual inspection for diagnosing cutaneous melanoma in adults.

Reflectance confocal microscopy for diagnosising keratinocyte skin cancers in adults (2018)
Journal Article

Background Early accurate detection of all skin cancer types is important to guide appropriate management and to improve morbidity and survival. Basal cell carcinoma (BCC) is usually a localised skin cancer but with potential to infiltrate and damag... Read More about Reflectance confocal microscopy for diagnosising keratinocyte skin cancers in adults.

Reflectance confocal microscopy for diagnosing cutaneous melanoma in adults (2018)
Journal Article

Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Early detection and treatment is key to improving sur... Read More about Reflectance confocal microscopy for diagnosing cutaneous melanoma in adults.

High frequency ultrasound for the diagnosis of skin cancer in adults (2018)
Journal Article

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high risk skin cancers which have the potential to metast... Read More about High frequency ultrasound for the diagnosis of skin cancer in adults.

Smartphone applications for triaging adults with skin lesions that are suspicious for melanoma (2018)
Journal Article

Background: Melanoma accounts for a small proportion of all skin cancer cases but is responsible for the majority of skin cancer-related deaths. Early detection and treatment can improve survival. Smartphone applications are readily accessible and po... Read More about Smartphone applications for triaging adults with skin lesions that are suspicious for melanoma.

Exfoliative cytology for the diagnosis of basal cell carcinoma and other skin cancers in adults (2018)
Journal Article

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to reduce morbidity and improve survival. Basal cell carcinoma (BCC) is usually localised to the skin with potential to infiltrate and dama... Read More about Exfoliative cytology for the diagnosis of basal cell carcinoma and other skin cancers in adults.

Teledermatology for the diagnosis of skin cancer in adults (2018)
Journal Article

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high risk skin cancers which have the potential to metast... Read More about Teledermatology for the diagnosis of skin cancer in adults.

Measurement of the total angiotensinogen and its reduced and oxidised forms in human plasma using targeted LC-MS/MS (2018)
Journal Article

Angiotensinogen (AGT) is a critical protein in the renin-angiotensin-aldosterone system and may have an important role in the pathogenesis of pre-eclampsia. The disulphide linkage between cysteines 18 and 138 has a key role in the redox switch of AGT... Read More about Measurement of the total angiotensinogen and its reduced and oxidised forms in human plasma using targeted LC-MS/MS.

Imagined constructed thought: how staff interpret the behaviour of patients with intellectual disabilities (2018)
Journal Article

This paper examines ‘imagined constructed thought’: speakers giving voice to the inner world of a non-present other. Drawing on 9 hours of video footage of health-care staff discussing patients with intellectual disabilities during Discovery Awarenes... Read More about Imagined constructed thought: how staff interpret the behaviour of patients with intellectual disabilities.

Limitations of current in vitro models for testing the clinical potential of epigenetic inhibitors for treatment of pediatric ependymoma (2018)
Journal Article

Background: Epigenetic modifications have been shown to play an important role in the classification and pathogenesis of the pediatric brain tumor ependymoma, suggesting they are a potential therapeutic target. Results: Agents targeting epigenetic... Read More about Limitations of current in vitro models for testing the clinical potential of epigenetic inhibitors for treatment of pediatric ependymoma.

Clinical assessment of depth sensor based pose estimation algorithms for technology supervised rehabilitation applications (2018)
Journal Article

Encouraging rehabilitation by the use of technology in the home can be a cost-effective strategy, particularly if consumer-level equipment can be used. We present a clinical qualitative and quantitative analysis of the pose estimation algorithms of a... Read More about Clinical assessment of depth sensor based pose estimation algorithms for technology supervised rehabilitation applications.

A tolerability and patient acceptability pilot study of a novel antimicrobial urinary catheter for long-term use (2018)
Journal Article

© 2018 Wiley Periodicals, Inc. Aims: We have developed a novel antimicrobial urinary catheter (AUC) impregnated with rifampicin, triclosan, and sparfloxacin and demonstrated that it has long-term (∼84 days) protection against bacterial colonization i... Read More about A tolerability and patient acceptability pilot study of a novel antimicrobial urinary catheter for long-term use.

Developing an integrated rehabilitation model for thoracic cancer services: views of patients, carers and clinicians (2018)
Journal Article

Background: Access to rehabilitation to prevent disability and optimise function is recommended for patients with cancer, including following cancer diagnosis. Models to integrate rehabilitation within oncology services as cancer treatment commences... Read More about Developing an integrated rehabilitation model for thoracic cancer services: views of patients, carers and clinicians.

The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation (2018)
Journal Article

Objective To evaluate the impact of the Quintet Recruitment Intervention (QRI) on recruitment in challenging randomized controlled trials (RCTs) that have applied the intervention. The QRI aims to understand recruitment difficulties, and then implem... Read More about The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation.

Targeting PARP1 in XRCC1-deficient sporadic invasive breast cancer or preinvasive ductal carcinoma in situ induces synthetic lethality and chemoprevention (2018)
Journal Article

© 2018 American Association for Cancer Research. Targeting PARP1 for synthetic lethality is a new strategy for breast cancers harboring germline mutations in BRCA. However, these mutations are rare, and reactivation of BRCA-mediated pathways may resu... Read More about Targeting PARP1 in XRCC1-deficient sporadic invasive breast cancer or preinvasive ductal carcinoma in situ induces synthetic lethality and chemoprevention.

Rapid and accurate analysis of stem cell-derived extracellular vesicles with super resolution microscopy and live imaging (2018)
Journal Article

Extracellular vesicles (EVs) have prevalent roles in cancer biology and regenerative medicine. Conventional techniques for characterising EVs including electron microscopy (EM), nanoparticle tracking analysis (NTA) and tuneable resistive pulse sensin... Read More about Rapid and accurate analysis of stem cell-derived extracellular vesicles with super resolution microscopy and live imaging.

A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis, muscle mass and function, in older adults (2018)
Journal Article

Age-related sarcopenia and dynapenia are associated with frailty and metabolic diseases. Resistance exercise training (RET) adjuvant to evidence-based nutritional intervention(s) have been shown as mitigating strategies. Given that HMB supplementatio... Read More about A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis, muscle mass and function, in older adults.