All Outputs (4)

Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study (2024)
Journal Article
Cowie, R. M., Macri-Pellizzeri, L., McLaren, J., Sanderson, W. J., Felfel, R. M., Scotchford, C. A., …Jennings, L. M. (2024). Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study. Royal Society Open Science, 11(1), Article 230431. https://doi.org/10.1098/rsos.230431

Osteochondral grafts are used for repair of focal osteochondral lesions. Autologous grafts are the gold standard treatment; however, limited graft availability and donor site morbidity restrict use. Therefore, there is a clinical need for different g... Read More about Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study.

Development and in vitro assessment of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold (2022)
Journal Article
Pitrolino, K. A., Felfel, R. M., Pellizzeri, L. M., McLaren, J., Popov, A. A., Sottile, V., …Grant, D. M. (2022). Development and in vitro assessment of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold. Carbohydrate Polymers, 282, Article 119126. https://doi.org/10.1016/j.carbpol.2022.119126

An innovative approach was developed to engineer a multi-layered chitosan scaffold for osteochondral defect repair. A combination of freeze drying and porogen-leaching out methods produced a porous, bioresorbable scaffold with a distinct gradient of... Read More about Development and in vitro assessment of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold.

Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering (2020)
Journal Article
Amer, M. H., Alvarez-Paino, M., McLaren, J., Pappalardo, F., Trujillo, S., Wong, J. Q., …Rose, F. R. (2021). Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering. Biomaterials, 266, Article 120450. https://doi.org/10.1016/j.biomaterials.2020.120450

© 2020 The Authors Mesenchymal stem cells are the focus of intense research in bone development and regeneration. The potential of microparticles as modulating moieties of osteogenic response by utilizing their architectural features is demonstrated... Read More about Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering.

Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model (2019)
Journal Article
McLaren, J. S., Macri-Pellizzeri, L., Zakir Hossain, K. M., Patel, U., Grant, D. M., Scammell, B. E., …Sottile, V. (2019). Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model. ACS Applied Materials and Interfaces, 11(17), 15436–15446. https://doi.org/10.1021/acsami.9b04603

Phosphate-based glasses (PBG) are bioactive and fully degradable materials with tailorable degradation rates. PBGs can be produced as porous microspheres through a single-step process, using changes in their formulation and geometry to produce varyin... Read More about Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model.