Raelene M. Cowie
Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study
Cowie, Raelene M.; Macri-Pellizzeri, Laura; McLaren, Jane; Sanderson, William J.; Felfel, Reda M.; Scotchford, Colin A.; Scammell, Brigitte E.; Grant, David M.; Sottile, Virginie; Jennings, Louise M.
Authors
LAURA MACRI PELLIZZERI Laura.Macripellizzeri@nottingham.ac.uk
Building Team Senior Technician
JANE MCLAREN jane.mclaren@nottingham.ac.uk
Nottingham Senior Tissue Bank Manager
William J. Sanderson
Reda M. Felfel
COLIN SCOTCHFORD COLIN.SCOTCHFORD@NOTTINGHAM.AC.UK
Associate Professor
Brigitte E. Scammell
DAVID GRANT DAVID.GRANT@NOTTINGHAM.AC.UK
Professor of Materials Science
Virginie Sottile
Louise M. Jennings
Abstract
Osteochondral grafts are used for repair of focal osteochondral lesions. Autologous grafts are the gold standard treatment; however, limited graft availability and donor site morbidity restrict use. Therefore, there is a clinical need for different graft sources/materials which replicate natural cartilage function. Chitosan has been proposed for this application. The aim of this study was to assess the biomechanics and biotribology of a bioresorbable chitosan/chitosan-nano-hydroxyapatite osteochondral construct (OCC), implanted in an in vitro porcine knee experimental simulation model. The OCC implanted in different surgical positions (flush, proud and inverted) was compared to predicate grafts in current clinical use and a positive control consisting of a stainless steel graft implanted proud of the cartilage surface. After 3 h (10 800 cycles) wear simulation under a walking gait, subsidence occurred in all OCC samples irrespective of surgical positioning, but with no apparent loss of material and low meniscus wear. Half the predicate grafts exhibited delamination and scratching of the cartilage surfaces. No graft subsidence occurred in the positive controls but wear and deformation of the meniscus were apparent. Implanting a new chitosan-based OCC either optimally (flush), inverted or proud of the cartilage surface resulted in minimal wear, damage and deformation of the meniscus.
Citation
Cowie, R. M., Macri-Pellizzeri, L., McLaren, J., Sanderson, W. J., Felfel, R. M., Scotchford, C. A., …Jennings, L. M. (2024). Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study. Royal Society Open Science, 11(1), Article 230431. https://doi.org/10.1098/rsos.230431
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 8, 2023 |
Online Publication Date | Jan 10, 2024 |
Publication Date | 2024-01 |
Deposit Date | Feb 19, 2024 |
Publicly Available Date | Feb 20, 2024 |
Journal | Royal Society Open Science |
Electronic ISSN | 2054-5703 |
Publisher | The Royal Society |
Peer Reviewed | Peer Reviewed |
Volume | 11 |
Issue | 1 |
Article Number | 230431 |
DOI | https://doi.org/10.1098/rsos.230431 |
Keywords | Chitosan; tribology; osteochondral graft; natural knee joint; joint simulation |
Public URL | https://nottingham-repository.worktribe.com/output/29556743 |
Publisher URL | https://royalsocietypublishing.org/doi/10.1098/rsos.230431 |
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Functional performance of abi-layered chitosan-nano-hydroxyapatite osteochondralscaffold: a pre-clinical in vitro tribological study
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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