All Outputs (1405)

Arginine dependence of acute myeloid leukaemia blast proliferation: a novel therapeutic target (2015)
Journal Article

Acute myeloid leukemia (AML) is one of the most common acute leukemias in adults and children, yet significant numbers of patients relapse and die of disease. In this study, we identify the dependence of AML blasts on arginine for proliferation. We s... Read More about Arginine dependence of acute myeloid leukaemia blast proliferation: a novel therapeutic target.

IL-36? induces maturation of Th1-inducing human MDDC and synergises with IFN-? to induce high surface expression of CD14 and CD11c (2015)
Journal Article

We show that IL-36? induced maturation of human MDDCs and stimulated differentiation of IFN-? producing (Type 1) CD3+ lymphocytes but was not as effective as IL-36? in doing so. For the first time, we also show that IL-36? induced expression of CD14... Read More about IL-36? induces maturation of Th1-inducing human MDDC and synergises with IFN-? to induce high surface expression of CD14 and CD11c.

The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses (2015)
Journal Article

PA-X is a novel protein encoded by PA mRNA and is found to decrease the pathogenicity of pandemic 1918 H1N1 virus in mice. However, the importance of PA-X proteins in current epidemiologically important influenza A virus strains is not known. In this... Read More about The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses.

Triaging informative cis-regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development (2015)
Journal Article

Background: Over 2700 genes are subject to stage-specific regulation during the intraerythrocytic development of the human malaria parasite Plasmodium falciparum. Bioinformatic analyses have identified a large number of over-represented motifs in the... Read More about Triaging informative cis-regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development.

Body composition and behaviour in adult rats are influenced by maternal diet, maternal age and high-fat feeding (2015)
Journal Article

Fetal exposure to maternal undernutrition has lifelong consequences for physiological and metabolic function. Maternal low-protein diet is associated with an age-related phenotype in rats, characterised by a period of resistance to development of obe... Read More about Body composition and behaviour in adult rats are influenced by maternal diet, maternal age and high-fat feeding.

Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring (2015)
Journal Article

Maternal caloric restriction during late gestation reduces birth weight, but whether long-term adverse metabolic outcomes of intra-uterine growth retardation (IUGR) are dependent on either accelerated postnatal growth or exposure to an obesogenic env... Read More about Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring.

Area of hock hair loss in dairy cows : risk factors and correlation to a categorical scale (2015)
Journal Article

Data from 3691 dairy cows from 76 farms were used to investigate the risk factors associated with area of hair loss over the lateral aspect of the hock, and the correlation between the area of hair loss as calculated using a hock map and hock lesion... Read More about Area of hock hair loss in dairy cows : risk factors and correlation to a categorical scale.

Skin malformations in a neonatal foal tested homozygous positive for Warmblood Fragile Foal Syndrome (2015)
Journal Article

BACKGROUND: Skin malformations that resembled manifestations of Ehlers-Danlos-Syndrome were described in a variety of domestic animals during the last century as cutis hyperelastica, hyperelastosis cutis, dermatosparaxis, dermal/collagen dysplasia... Read More about Skin malformations in a neonatal foal tested homozygous positive for Warmblood Fragile Foal Syndrome.

Dairy herd mastitis and reproduction: using simulation to aid interpretation of results from discrete time survival analysis (2015)
Journal Article

Probabilistic sensitivity analysis (PSA) is a simulation-based technique for evaluating the relative importance of different inputs to a complex process model. It is commonly employed in decision analysis and for evaluation of the potential impact of... Read More about Dairy herd mastitis and reproduction: using simulation to aid interpretation of results from discrete time survival analysis.

Investigating common clinical presentations in first opinion small animal consultations using direct observation (2015)
Journal Article

Understanding more about the clinical presentations encountered in veterinary practice is vital in directing research towards areas relevant to practitioners. The aim of this study was to describe all problems discussed during a convenience sample of... Read More about Investigating common clinical presentations in first opinion small animal consultations using direct observation.

Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells (2015)
Journal Article

Transgenic mice overexpressing the high mobility group A (HMGA) genes, Hmga1 or Hmga2 develop pituitary tumours and their overexpression is also a frequent finding in human pituitary adenomas. In some cases, increased expression of HMGA2 but not that... Read More about Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells.

Persistence of scrapie infectivity within a farm environment after cleaning and decontamination (2015)
Journal Article

Scrapie of sheep/goats and Chronic Wasting Disease (CWD) of deer/elk are contagious prion diseases where environmental reservoirs are directly implicated in the transmission of disease. In this study the effectiveness of recommended scrapie farm deco... Read More about Persistence of scrapie infectivity within a farm environment after cleaning and decontamination.

Lameness in cattle: recent research to inform clinical practice (2015)
Journal Article

Lameness in cattle has significant consequences for welfare, health and productivity. More research is now being done on lameness and this article, the first in a two-part series, provides an update on research-based advances in the field published f... Read More about Lameness in cattle: recent research to inform clinical practice.

Chicken and duck myotubes are highly susceptible and permissive to influenza virus infection (2014)
Journal Article

Skeletal muscle, at 30 to 40% of body mass, is the most abundant soft tissue in the body. Besides its primary function in movement and posture, skeletal muscle is a significant innate immune organ with the capacity to produce cytokines and chemokines... Read More about Chicken and duck myotubes are highly susceptible and permissive to influenza virus infection.

The effects of age upon the expression of three miRNAs in muscle stem cells isolated from two different porcine skeletal muscles (2014)
Journal Article

Aging is associated with a gradual loss of skeletal muscle mass and an impaired ability of this tissue to compensate for trauma. Studies in rodents and humans have also shown that resident stem cells within muscle have a reduced ability to proliferat... Read More about The effects of age upon the expression of three miRNAs in muscle stem cells isolated from two different porcine skeletal muscles.

Patterns of genome evolution that have accompanied host adaptation in Salmonella (2014)
Journal Article

Many bacterial pathogens are specialized, infecting one or few hosts, and this is often associated with more acute disease presentation. Specific genomes show markers of this specialization, which often reflect a balance between gene acquisition and... Read More about Patterns of genome evolution that have accompanied host adaptation in Salmonella.

An investigation of the efficacy of a polyvalent mastitis vaccine using different vaccination regimens under field conditions in the United Kingdom (2014)
Journal Article

Vaccination can play a useful role in mastitis control programs, although there is a relative dearth of large, well-controlled field efficacy studies. This paper presents the findings on the use of a commercially available vaccine (Startvac, Hipra UK... Read More about An investigation of the efficacy of a polyvalent mastitis vaccine using different vaccination regimens under field conditions in the United Kingdom.

Prebiotic and probiotic agents enhance antibody-based immune responses to Salmonella Typhimurium infection in pigs (2014)
Journal Article

Salmonellosis causes significant economic losses to the pig industry and contaminated pork products are an important source of Salmonella for humans. The EU ban on the use of antibiotic growth promoters in pig production, and the emergence of antibio... Read More about Prebiotic and probiotic agents enhance antibody-based immune responses to Salmonella Typhimurium infection in pigs.

Variation in the inter-service intervals of UK dairy cows (2014)
Journal Article

An understanding of the normal estrous cycle length of the cow is important when managing and monitoring dairy herd fertility. Whilst the normal inter-ovulatory interval is widely considered to be 21 days, some studies have found alternative interval... Read More about Variation in the inter-service intervals of UK dairy cows.

Influence of 1?, 25-dihydroxyvitamin D3 [1, 25(OH)2D3] on the expression of Sox 9 and the transient receptor potential vanilloid 5/6 ion channels in equine articular chondrocytes (2014)
Journal Article

Background Sox 9 is a major marker of chondrocyte differentiation. When chondrocytes are cultured in vitro they progressively de-differentiate and this is associated with a decline in Sox 9 expression. The active form of vitamin D, 1, 25 (OH)2D3... Read More about Influence of 1?, 25-dihydroxyvitamin D3 [1, 25(OH)2D3] on the expression of Sox 9 and the transient receptor potential vanilloid 5/6 ion channels in equine articular chondrocytes.