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Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes (2022)
Journal Article
White, K., Aldurdunji, M., Harris, J., Ortori, C., & Paine, S. (2022). Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes. Pharmacology Research and Perspectives, 10(6), Article e01031. https://doi.org/10.1002/prp2.1031

The translation of new injectable anaesthetic drugs from rodent to humans remains slow, despite the realisation that reliance on the volatile agents is unsustainable from an environmental perspective. The aim of this study was to investigate the infl... Read More about Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes.

Emergence of equine influenza virus H3Nx Florida clade 2 in Arabian racehorses in Egypt (2022)
Journal Article
Ahmed, B. M., Bayoumi, M. M., Farrag, M. A., Elgamal, A., Daly, J. M., & Amer, H. M. (2022). Emergence of equine influenza virus H3Nx Florida clade 2 in Arabian racehorses in Egypt. Virology Journal, 19, Article 185. https://doi.org/10.1186/s12985-022-01917-9

Background Equine influenza is an important cause of respiratory disease in equids. The causative virus; EIV, is highly variable and can evolve by accumulation of mutations, particularly in the haemagglutinin (HA) gene. Currently, H3N8 is the sole... Read More about Emergence of equine influenza virus H3Nx Florida clade 2 in Arabian racehorses in Egypt.

Indication of a personality trait in dairy calves and its link to weight gain through automatically collected feeding behaviours (2022)
Journal Article
Carslake, C., Occhiuto, F., Vázquez-Diosdado, J. A., & Kaler, J. (2022). Indication of a personality trait in dairy calves and its link to weight gain through automatically collected feeding behaviours. Scientific Reports, 12(1), Article 19425. https://doi.org/10.1038/s41598-022-24076-x

Farm animal personality traits are of interest since they can help predict individual variation in behaviour and productivity. However, personality traits are currently inferred using behavioural tests which are impractical outside of research settin... Read More about Indication of a personality trait in dairy calves and its link to weight gain through automatically collected feeding behaviours.

Ossa cordis and os aorta in the one‐humped camel: Computed tomography, light microscopy and morphometric analysis (2022)
Journal Article
El‐Gendy, S. A., Alsafy, M. A., Rutland, C. S., Ez Elarab, S. M., Abd‐Elhafeez, H. H., & Kamal, B. M. (2023). Ossa cordis and os aorta in the one‐humped camel: Computed tomography, light microscopy and morphometric analysis. Microscopy Research and Technique, 86(1), 53-62. https://doi.org/10.1002/jemt.24256

The present study describes the morphological characteristics of the camel heart Ossa cordis, and os aorta using computed tomography soft tissue window (CT) alongside 3D render volume reconstructions and light microscopy. The current study techniques... Read More about Ossa cordis and os aorta in the one‐humped camel: Computed tomography, light microscopy and morphometric analysis.

Next-Generation Phage Display to Identify Peptide Ligands of Deubiquitinases (2022)
Book Chapter
Spiliotopoulos, A., Maurer, S. K., Tsoumpeli, M. T., Bonfante, J. A. F., Owen, J. P., Gough, K. C., & Dreveny, I. (2023). Next-Generation Phage Display to Identify Peptide Ligands of Deubiquitinases. In J. Maupin-Furlow, & M. J. Edelmann (Eds.), Deubiquitinases: Methods and Protocols (189-218). Humana Press. https://doi.org/10.1007/978-1-0716-2803-4_12

Phage display (PD) is a powerful method and has been extensively used to generate monoclonal antibodies and identify epitopes, mimotopes, and protein interactions. More recently, the combination of next-generation sequencing (NGS) with PD (NGPD) has... Read More about Next-Generation Phage Display to Identify Peptide Ligands of Deubiquitinases.

The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity (2022)
Journal Article
Wallace, M. N., Zobay, O., Hardman, E., Thompson, Z., Dobbs, P., Chakrabarti, L., & Palmer, A. R. (2022). The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity. Frontiers in Neuroanatomy, 16, Article 1034264. https://doi.org/10.3389/fnana.2022.1034264

Minicolumns are thought to be a fundamental neural unit in the neocortex and their replication may have formed the basis of the rapid cortical expansion that occurred during primate evolution. We sought evidence of minicolumns in the primary visual c... Read More about The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity.

Farm animal careers and perception of ‘fit’ in undergraduate veterinary students: A mixed methods study (2022)
Journal Article
Payne, E., Morton, E., Lally, C., & Remnant, J. (2022). Farm animal careers and perception of ‘fit’ in undergraduate veterinary students: A mixed methods study. Veterinary Record, Article e2339. https://doi.org/10.1002/vetr.2339

Background: Recruitment and retention of farm veterinarians have been the focus of recent research. Previous work suggests that a feeling of ‘fit’ is important for students to consider a farm career. The aim of this study was to identify whether stud... Read More about Farm animal careers and perception of ‘fit’ in undergraduate veterinary students: A mixed methods study.

Mechanistic and Clinical Evidence Supports a Key Role for Cell Division Cycle Associated 5 (CDCA5) as an Independent Predictor of Outcome in Invasive Breast Cancer (2022)
Journal Article
Kariri, Y. A., Joseph, C., Alsaleem, M. A., Elsharawy, K. A., Alsaeed, S., Toss, M. S., …Rakha, E. A. (2022). Mechanistic and Clinical Evidence Supports a Key Role for Cell Division Cycle Associated 5 (CDCA5) as an Independent Predictor of Outcome in Invasive Breast Cancer. Cancers, 14(22), Article 5643. https://doi.org/10.3390/cancers14225643

Background: Cell Division Cycle Associated 5 (CDCA5) plays a role in the phosphoinositide 3-kinase (PI3K)/AKT/mTOR signalling pathway involving cell division, cancer cell migration and apoptosis. This study aims to assess the prognostic and biologica... Read More about Mechanistic and Clinical Evidence Supports a Key Role for Cell Division Cycle Associated 5 (CDCA5) as an Independent Predictor of Outcome in Invasive Breast Cancer.

Metabolic alterations in dairy cattle with lameness revealed by untargeted metabolomics of dried milk spots using direct infusion-tandem mass spectrometry and the triangulation of multiple machine learning models (2022)
Journal Article
He, W., Cardoso, A. S., Hyde, R. M., Green, M. J., Scurr, D. J., Griffiths, R., …Kim, D. (2022). Metabolic alterations in dairy cattle with lameness revealed by untargeted metabolomics of dried milk spots using direct infusion-tandem mass spectrometry and the triangulation of multiple machine learning models. Analyst, 147(23), 5537-5545. https://doi.org/10.1039/d2an01520j

Lameness is a major challenge in the dairy cattle industry in terms of animal welfare and economic implications. Better understanding of metabolic alteration associated with lameness could lead to early diagnosis and effective treatment{,} there-fore... Read More about Metabolic alterations in dairy cattle with lameness revealed by untargeted metabolomics of dried milk spots using direct infusion-tandem mass spectrometry and the triangulation of multiple machine learning models.

Successful use of a benchtop fluorescent enzyme immunoassay analyzer to measure serum cortisol concentration as a screening test for hypoadrenocorticism in dogs (2022)
Journal Article
Bacon, J., Graham, P. A., Hrovat, A., Kilpatrick, S., Mann, N. O., & Swales, H. (2023). Successful use of a benchtop fluorescent enzyme immunoassay analyzer to measure serum cortisol concentration as a screening test for hypoadrenocorticism in dogs. Journal of the American Veterinary Medical Association, 261(1), 111-117. https://doi.org/10.2460/javma.22.08.0346

OBJECTIVE To assess the diagnostic performance of a benchtop fluorescent enzyme immunoassay analyzer (AIA-360; Tosoh Bioscience Inc) for the measurement of serum cortisol concentration as a screening test for hypoadrenocorticism in dogs. ANIMALS 173... Read More about Successful use of a benchtop fluorescent enzyme immunoassay analyzer to measure serum cortisol concentration as a screening test for hypoadrenocorticism in dogs.

Gut transcriptome reveals differential gene expression and enriched pathways linked to immune activation in response to weaning in pigs (2022)
Journal Article
Le Bon, M., Tötemeyer, S., Emes, R. D., & Mellits, K. H. (2022). Gut transcriptome reveals differential gene expression and enriched pathways linked to immune activation in response to weaning in pigs. Frontiers in Genetics, 13, Article 961474. https://doi.org/10.3389/fgene.2022.961474

Weaning represents one of the most critical periods in pig production associated with increase in disease risk, reduction in performance and economic loss. Physiological changes faced by piglets during the weaning period have been well characterised,... Read More about Gut transcriptome reveals differential gene expression and enriched pathways linked to immune activation in response to weaning in pigs.

The effects of oral drenching with Co or vitamin B12, drenching frequency and Co via rumen bolus on plasma vitamin B12 concentration in weaned lambs (2022)
Journal Article
Hession, D., Kendall, N., Hanrahan, J., & Keady, T. (2022). The effects of oral drenching with Co or vitamin B12, drenching frequency and Co via rumen bolus on plasma vitamin B12 concentration in weaned lambs. Livestock Science, 266, Article 105108. https://doi.org/10.1016/j.livsci.2022.105108

Weaned lambs (n = 88) were stratified by sex and body weight (BW) and allocated at random to 1 of 10 treatments for 12 weeks (consecutive 6-week periods), to evaluate the effects of supplementation with Co or vitamin B12 (B12) on the concentrations o... Read More about The effects of oral drenching with Co or vitamin B12, drenching frequency and Co via rumen bolus on plasma vitamin B12 concentration in weaned lambs.

Vitamin D status in chimpanzees in human care: a Europe wide study (2022)
Journal Article
Moittié, S., Jarvis, R., Bandelow, S., Byrne, S., Dobbs, P., Grant, M., …Baiker, K. (2022). Vitamin D status in chimpanzees in human care: a Europe wide study. Scientific Reports, 12, Article 17625. https://doi.org/10.1038/s41598-022-21211-6

While vitamin D deficiency is a public health concern in humans, comparatively little is known about vitamin D levels in non-human primates. Vitamin D plays a crucial role in overall health and its deficiency is associated with a range of disorders,... Read More about Vitamin D status in chimpanzees in human care: a Europe wide study.

Camellia sinensis solvent extract, epigallocatechin gallate and caffeine confer trophocidal and cysticidal effects against Acanthamoeba castellanii (2022)
Journal Article
Fakae, L. B., Harun, M. S., Ting, D. S. J., Dua, H. S., Cave, G. W., Zhu, X. Q., …Elsheikha, H. M. (2023). Camellia sinensis solvent extract, epigallocatechin gallate and caffeine confer trophocidal and cysticidal effects against Acanthamoeba castellanii. Acta Tropica, 237, Article 106729. https://doi.org/10.1016/j.actatropica.2022.106729

We examined the anti-acanthamoebic efficacy of green tea Camellia sinensis solvent extract (SE) or its chemical constituents against Acanthamoeba castellanii by using anti-trophozoite, anti-encystation, and anti-excystation assays. C. sinensis SE (62... Read More about Camellia sinensis solvent extract, epigallocatechin gallate and caffeine confer trophocidal and cysticidal effects against Acanthamoeba castellanii.

SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus (2022)
Journal Article
Li, Q., Jiang, Z., Ren, S., Guo, H., Song, Z., Chen, S., …Liu, J. (2022). SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus. Advanced Science, 9(34), Article 2203088. https://doi.org/10.1002/advs.202203088

Splicing of influenza A virus (IAV) RNA is an essential process in the viral life cycle that involves the co-opting of host factors. Here, it is demonstrated that induction of host serine and arginine-rich splicing factor 5 (SRSF5) by IAV facilitated... Read More about SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus.

Defining invasion in breast cancer: the role of basement membrane (2022)
Journal Article
Ghannam, S. F., Rutland, C. S., Allegrucci, C., Mongan, N. P., & Rakha, E. (2022). Defining invasion in breast cancer: the role of basement membrane. Journal of Clinical Pathology, https://doi.org/10.1136/jcp-2022-208584

Basement membrane (BM) is an amorphous, sheet-like structure separating the epithelium from the stroma. BM is characterised by a complex structure comprising collagenous and non-collagenous proteoglycans and glycoproteins. In the breast, the thicknes... Read More about Defining invasion in breast cancer: the role of basement membrane.

GIFT: New method for the genetic analysis of small gene effects involving small sample sizes (2022)
Journal Article
Rauch, C., Kyratzi, P., Blott, S., Bray, S., & Wattis, J. A. D. (2023). GIFT: New method for the genetic analysis of small gene effects involving small sample sizes. Physical Biology, 20(1), Article 016001. https://doi.org/10.1088/1478-3975/ac99b3

Small gene effects involved in complex/omnigenic traits remain costly to analyse using current genome-wide association methods (GWAS) because of the number of individuals required to return meaningful association(s), a.k.a. study power. Inspired by f... Read More about GIFT: New method for the genetic analysis of small gene effects involving small sample sizes.

Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer (2022)
Journal Article
Harris, A. E., Metzler, V. M., Lothion-Roy, J., Varun, D., Woodcock, C. L., Haigh, D. B., …Jeyapalan, J. N. (2022). Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer. Frontiers in Endocrinology, 13, Article 1006101. https://doi.org/10.3389/fendo.2022.1006101

Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g. abiraterone) or by antagonizing androgen receptor (AR) function (e.g. bic... Read More about Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer.

The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer (2022)
Journal Article
Haigh, D. B., Woodcock, C. L., Lothion-Roy, J., Harris, A. E., Metzler, V. M., Persson, J. L., …Mongan, N. P. (2022). The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer. Cancers, 14(20), Article 5148. https://doi.org/10.3390/cancers14205148

Prostate cancer (PCa) is a leading cause of cancer-related deaths and is driven by aberrant androgen receptor (AR) signalling. For this reason, androgen deprivation therapies (ADTs) that suppress androgen-induced PCa progression either by preventing... Read More about The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer.