All Outputs (166)

Seroprevalence of Equine Influenza and Its Associated Risk Factors in Northwest Nigeria (2022)
Journal Article

Equine influenza (EI) is a fast-spreading respiratory disease of equids caused by equine influenza A virus (EIV), often resulting in high morbidity and a huge economic impact on the equine industry globally. In this cross-sectional study to determine... Read More about Seroprevalence of Equine Influenza and Its Associated Risk Factors in Northwest Nigeria.

Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes (2022)
Journal Article

The translation of new injectable anaesthetic drugs from rodent to humans remains slow, despite the realisation that reliance on the volatile agents is unsustainable from an environmental perspective. The aim of this study was to investigate the infl... Read More about Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes.

Emergence of equine influenza virus H3Nx Florida clade 2 in Arabian racehorses in Egypt (2022)
Journal Article

Background Equine influenza is an important cause of respiratory disease in equids. The causative virus; EIV, is highly variable and can evolve by accumulation of mutations, particularly in the haemagglutinin (HA) gene. Currently, H3N8 is the sole... Read More about Emergence of equine influenza virus H3Nx Florida clade 2 in Arabian racehorses in Egypt.

Indication of a personality trait in dairy calves and its link to weight gain through automatically collected feeding behaviours (2022)
Journal Article

Farm animal personality traits are of interest since they can help predict individual variation in behaviour and productivity. However, personality traits are currently inferred using behavioural tests which are impractical outside of research settin... Read More about Indication of a personality trait in dairy calves and its link to weight gain through automatically collected feeding behaviours.

Next-Generation Phage Display to Identify Peptide Ligands of Deubiquitinases (2022)
Book Chapter

Phage display (PD) is a powerful method and has been extensively used to generate monoclonal antibodies and identify epitopes, mimotopes, and protein interactions. More recently, the combination of next-generation sequencing (NGS) with PD (NGPD) has... Read More about Next-Generation Phage Display to Identify Peptide Ligands of Deubiquitinases.

Ossa cordis and os aorta in the one‐humped camel: Computed tomography, light microscopy and morphometric analysis (2022)
Journal Article

The present study describes the morphological characteristics of the camel heart Ossa cordis, and os aorta using computed tomography soft tissue window (CT) alongside 3D render volume reconstructions and light microscopy. The current study techniques... Read More about Ossa cordis and os aorta in the one‐humped camel: Computed tomography, light microscopy and morphometric analysis.

The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity (2022)
Journal Article

Minicolumns are thought to be a fundamental neural unit in the neocortex and their replication may have formed the basis of the rapid cortical expansion that occurred during primate evolution. We sought evidence of minicolumns in the primary visual c... Read More about The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity.

Farm animal careers and perception of ‘fit’ in undergraduate veterinary students: A mixed methods study (2022)
Journal Article

Background: Recruitment and retention of farm veterinarians have been the focus of recent research. Previous work suggests that a feeling of ‘fit’ is important for students to consider a farm career. The aim of this study was to identify whether stud... Read More about Farm animal careers and perception of ‘fit’ in undergraduate veterinary students: A mixed methods study.

Mechanistic and Clinical Evidence Supports a Key Role for Cell Division Cycle Associated 5 (CDCA5) as an Independent Predictor of Outcome in Invasive Breast Cancer (2022)
Journal Article

Background: Cell Division Cycle Associated 5 (CDCA5) plays a role in the phosphoinositide 3-kinase (PI3K)/AKT/mTOR signalling pathway involving cell division, cancer cell migration and apoptosis. This study aims to assess the prognostic and biologica... Read More about Mechanistic and Clinical Evidence Supports a Key Role for Cell Division Cycle Associated 5 (CDCA5) as an Independent Predictor of Outcome in Invasive Breast Cancer.

Metabolic alterations in dairy cattle with lameness revealed by untargeted metabolomics of dried milk spots using direct infusion-tandem mass spectrometry and the triangulation of multiple machine learning models (2022)
Journal Article

Lameness is a major challenge in the dairy cattle industry in terms of animal welfare and economic implications. Better understanding of metabolic alteration associated with lameness could lead to early diagnosis and effective treatment{,} there-fore... Read More about Metabolic alterations in dairy cattle with lameness revealed by untargeted metabolomics of dried milk spots using direct infusion-tandem mass spectrometry and the triangulation of multiple machine learning models.

Successful use of a benchtop fluorescent enzyme immunoassay analyzer to measure serum cortisol concentration as a screening test for hypoadrenocorticism in dogs (2022)
Journal Article

OBJECTIVE To assess the diagnostic performance of a benchtop fluorescent enzyme immunoassay analyzer (AIA-360; Tosoh Bioscience Inc) for the measurement of serum cortisol concentration as a screening test for hypoadrenocorticism in dogs. ANIMALS 173... Read More about Successful use of a benchtop fluorescent enzyme immunoassay analyzer to measure serum cortisol concentration as a screening test for hypoadrenocorticism in dogs.

Gut transcriptome reveals differential gene expression and enriched pathways linked to immune activation in response to weaning in pigs (2022)
Journal Article

Weaning represents one of the most critical periods in pig production associated with increase in disease risk, reduction in performance and economic loss. Physiological changes faced by piglets during the weaning period have been well characterised,... Read More about Gut transcriptome reveals differential gene expression and enriched pathways linked to immune activation in response to weaning in pigs.

The effects of oral drenching with Co or vitamin B12, drenching frequency and Co via rumen bolus on plasma vitamin B12 concentration in weaned lambs (2022)
Journal Article

Weaned lambs (n = 88) were stratified by sex and body weight (BW) and allocated at random to 1 of 10 treatments for 12 weeks (consecutive 6-week periods), to evaluate the effects of supplementation with Co or vitamin B12 (B12) on the concentrations o... Read More about The effects of oral drenching with Co or vitamin B12, drenching frequency and Co via rumen bolus on plasma vitamin B12 concentration in weaned lambs.

Camellia sinensis solvent extract, epigallocatechin gallate and caffeine confer trophocidal and cysticidal effects against Acanthamoeba castellanii (2022)
Journal Article

We examined the anti-acanthamoebic efficacy of green tea Camellia sinensis solvent extract (SE) or its chemical constituents against Acanthamoeba castellanii by using anti-trophozoite, anti-encystation, and anti-excystation assays. C. sinensis SE (62... Read More about Camellia sinensis solvent extract, epigallocatechin gallate and caffeine confer trophocidal and cysticidal effects against Acanthamoeba castellanii.

Vitamin D status in chimpanzees in human care: a Europe wide study (2022)
Journal Article

While vitamin D deficiency is a public health concern in humans, comparatively little is known about vitamin D levels in non-human primates. Vitamin D plays a crucial role in overall health and its deficiency is associated with a range of disorders,... Read More about Vitamin D status in chimpanzees in human care: a Europe wide study.

SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus (2022)
Journal Article

Splicing of influenza A virus (IAV) RNA is an essential process in the viral life cycle that involves the co-opting of host factors. Here, it is demonstrated that induction of host serine and arginine-rich splicing factor 5 (SRSF5) by IAV facilitated... Read More about SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus.

Defining invasion in breast cancer: the role of basement membrane (2022)
Journal Article

Basement membrane (BM) is an amorphous, sheet-like structure separating the epithelium from the stroma. BM is characterised by a complex structure comprising collagenous and non-collagenous proteoglycans and glycoproteins. In the breast, the thicknes... Read More about Defining invasion in breast cancer: the role of basement membrane.

GIFT: New method for the genetic analysis of small gene effects involving small sample sizes (2022)
Journal Article

Small gene effects involved in complex/omnigenic traits remain costly to analyse using current genome-wide association methods (GWAS) because of the number of individuals required to return meaningful association(s), a.k.a. study power. Inspired by f... Read More about GIFT: New method for the genetic analysis of small gene effects involving small sample sizes.

Study design synopsis: Evidence syntheses—What are they and why do we need them? (2022)
Journal Article

Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer (2022)
Journal Article

Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g. abiraterone) or by antagonizing androgen receptor (AR) function (e.g. bic... Read More about Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer.