All Outputs (139)

Development and evaluation of real time RT-PCR assays for detection and typing of Bluetongue virus (2016)
Journal Article

Bluetongue virus is the type species of the genus Orbivirus, family Reoviridae. Bluetongue viruses (BTV) are transmitted between their vertebrate hosts primarily by biting midges (Culicoides spp.) in which they also replicate. Consequently BTV distri... Read More about Development and evaluation of real time RT-PCR assays for detection and typing of Bluetongue virus.

TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants (2016)
Journal Article

A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here... Read More about TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants.

TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants (2016)
Journal Article

A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here... Read More about TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants.

The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants Emulsigen® and the monomeric TLR5 ligand FliC in zebu cattle against AlHV-1 malignant catarrhal fever induced by experimental virus challenge (2016)
Journal Article

Malignant catarrhal fever (MCF) is a fatal disease of cattle that, in East Africa, follows contact with wildebeest excreting alcelaphine herpesvirus 1 (AlHV-1). Recently an attenuated vaccine (atAlHV-1) was tested under experimental challenge on Frie... Read More about The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants Emulsigen® and the monomeric TLR5 ligand FliC in zebu cattle against AlHV-1 malignant catarrhal fever induced by experimental virus challenge.

Factors influencing veterinary surgeons’ decision-making about dairy cattle vaccination (2016)
Journal Article

The use of vaccines in the cattle industry is widespread; however, there is limited published guidance for use by decision-makers such as farmers and vets. To best support vets in advising dairy farmers on the optimisation of vaccination strategies,... Read More about Factors influencing veterinary surgeons’ decision-making about dairy cattle vaccination.

A Bayesian micro-simulation to evaluate the cost-effectiveness of interventions for mastitis control during the dry period in UK dairy herds (2016)
Journal Article

Importance of the dry period with respect to mastitis control is now well established although the precise interventions that reduce the risk of acquiring intramammary infections during this time are not clearly understood. There are very few interve... Read More about A Bayesian micro-simulation to evaluate the cost-effectiveness of interventions for mastitis control during the dry period in UK dairy herds.

Multimodal assessment of estrogen receptor mRNA profiles to quantify estrogen pathway activity in breast tumors (2016)
Journal Article

Background Molecular markers have transformed our understanding of the heterogeneity of breast cancer and have allowed the identification of genomic profiles of estrogen receptor (ER)-? signaling. However, our understanding of the transcriptional... Read More about Multimodal assessment of estrogen receptor mRNA profiles to quantify estrogen pathway activity in breast tumors.

Lameness in dairy heifers; impacts of hoof lesions present around first calving on future lameness, milk yield and culling risk (2016)
Journal Article

The importance of lameness in primiparous dairy heifers is increasingly recognised. Although it is accepted that clinical lameness in any lactation increases the risk of future lameness, the impact of foot lesions during the first lactation on long-t... Read More about Lameness in dairy heifers; impacts of hoof lesions present around first calving on future lameness, milk yield and culling risk.

Acanthamoeba castellanii : A new high-throughput method for drug screening in vitro (2016)
Journal Article

Despite significant public health impact, there is no specific antiprotozoal therapy for prevention and treatment of Acanthamoeba castellanii infection. There is a need for new and efficient anti-Acanthamoeba drugs that are less toxic and can reduce... Read More about Acanthamoeba castellanii : A new high-throughput method for drug screening in vitro.

Ovine footrot: new insights into bacterial colonisation (2016)
Journal Article

Ovine footrot is characterised by interdigital dermatitis (ID) and by the separation of the skin and hoof horn (under-running footrot). Dichelobacter nodosus is the essential pathogen causing footrot; the role of other microorganisms in this disease... Read More about Ovine footrot: new insights into bacterial colonisation.

The influenza NS1 protein: what do we know in equine influenza virus pathogenesis? (2016)
Journal Article

Equine influenza virus remains a serious health and potential economic problem throughout most parts of the world, despite intensive vaccination programs in some horse populations. The influenza non-structural protein 1 (NS1) has multiple functions i... Read More about The influenza NS1 protein: what do we know in equine influenza virus pathogenesis?.

Targeted suppression of AR-V7 using PIP5K1? inhibitor overcomes enzalutamide resistance in prostate cancer cells (2016)
Journal Article

One mechanism of resistance of prostate cancer (PCa) to enzalutamide (MDV3100) treatment is the increased expression of AR variants lacking the ligand binding-domain, the best characterized of which is AR-V7. We have previously reported that Phosphat... Read More about Targeted suppression of AR-V7 using PIP5K1? inhibitor overcomes enzalutamide resistance in prostate cancer cells.

Ostertagia spp., rumen fluke and liver fluke single- and poly-infections in cattle: an abattoir study of prevalence and production impacts in England and Wales (2016)
Journal Article

This study aims at investigating the occurrence, risk factors and production impacts on beef carcassparameters of three of the most important cattle helminth infections in England and Wales. Abomasa, reticulorumens and livers from healthy cattle were... Read More about Ostertagia spp., rumen fluke and liver fluke single- and poly-infections in cattle: an abattoir study of prevalence and production impacts in England and Wales.

Detection of a Yersinia pestisgene homologue in rodent samples (2016)
Journal Article

A homologue to a widely used genetic marker, pla, for Yersinia pestis has been identified in tissue samples of two species of rat (Rattus rattus and Rattus norvegicus) and of mice (Mus musculus and Apodemus sylvaticus) using a microarray based platfo... Read More about Detection of a Yersinia pestisgene homologue in rodent samples.

‘Disperse abroad in the land’: the role of wildlife in the dissemination of antimicrobial resistance (2016)
Journal Article

Antimicrobial resistance (AMR) has been detected in the microbiota of many wildlife species, including long-distance migrants. Inadequately treated wastes from humans and livestock dosed with antimicrobial drugs are often assumed to be the main sourc... Read More about ‘Disperse abroad in the land’: the role of wildlife in the dissemination of antimicrobial resistance.

Oxytocin versus carbetocin administered to cows after uncomplicated calvings and subsequent fertility (2016)
Journal Article

BestBETs for Vets are generated by the Centre for Evidence-based Veterinary Medicine at the University of Nottingham to help answer specific questions and assist in clinical decision making. Although evidence is often limited, they aim to find, prese... Read More about Oxytocin versus carbetocin administered to cows after uncomplicated calvings and subsequent fertility.

Mapping B-cell responses to Salmonella enterica serovars Typhimurium and Enteritidis in chickens for the discrimination of infected from vaccinated animals (2016)
Journal Article

Serological surveillance and vaccination are important strategies for controlling infectious diseases of food production animals. However, the compatibility of these strategies is limited by a lack of assays capable of di erentiating infected from va... Read More about Mapping B-cell responses to Salmonella enterica serovars Typhimurium and Enteritidis in chickens for the discrimination of infected from vaccinated animals.

Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism (2016)
Journal Article

Adverse temporal trends in human semen quality and cryptorchidism in infants have been associated with exposure to environmental chemicals (ECs) during development. Here we report that a population of breeding dogs exhibit a 26 year (1988–2014) decli... Read More about Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism.

Subacute ruminal acidosis reduces sperm quality in beef bulls (2016)
Journal Article

Breeding bulls are commonly fed high-energy diets, which may induce subacute ruminal acidosis (SARA). In this experiment, 8 Santa Gertrudis bulls (age 20 ± 6 mo) were used to evaluate the extent and duration of effects of SARA on semen quality and th... Read More about Subacute ruminal acidosis reduces sperm quality in beef bulls.

Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection (2016)
Journal Article

Background Toxoplasma gondii is a worldwide spread pathogen which can infect all tissues of its host. The transcriptomic responses of infected brain and spleen have been reported. However, our knowledge of the global transcriptomic change in infec... Read More about Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection.