All Outputs (99)

The effect of prophylactic treatment with levetiracetam on the incidence of post-attenuation seizures in dogs undergoing surgical management of single congenital extrahepatic portosystemic shunts (2018)
Journal Article

Objectives: To report (1) the incidence of post-attenuation seizures (PAS) in dogs that underwent single congenital extrahepatic portosystemic shunt (cEHPSS) attenuation and (2) to compare incidence of PAS in dogs that either did or did not receive p... Read More about The effect of prophylactic treatment with levetiracetam on the incidence of post-attenuation seizures in dogs undergoing surgical management of single congenital extrahepatic portosystemic shunts.

Macrophage-derived IL-1? and TNF-? regulate arginine metabolism in neuroblastoma (2018)
Journal Article

© 2018 American Association for Cancer Research. Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regu... Read More about Macrophage-derived IL-1? and TNF-? regulate arginine metabolism in neuroblastoma.

A study of tuberculosis in road traffic-killed badgers on the edge of the British bovine TB epidemic area (2018)
Journal Article

The role of badgers in the geographic expansion of the bovine tuberculosis (bTB) epidemic in England is unknown: indeed there have been few published studies of bTB in badgers outside of the Southwest of England where the infection is now endemic in... Read More about A study of tuberculosis in road traffic-killed badgers on the edge of the British bovine TB epidemic area.

Centralized Trading, Transparency, and Interest Rate Swap Market Liquidity: Evidence from the Implementation of the Dodd–Frank Act (2018)
Journal Article

We use proprietary transaction data on interest rate swaps to assess the effects of centralized trading, as mandated by Dodd-Frank, on market quality. Contracts with the most extensive centralized trading see liquidity metrics improve by between 12%... Read More about Centralized Trading, Transparency, and Interest Rate Swap Market Liquidity: Evidence from the Implementation of the Dodd–Frank Act.

Low accuracy of Bayesian latent class analysis for estimation of herd-level true prevalence under certain disease characteristics—An analysis using simulated data (2018)
Journal Article

Estimation of the true prevalence of infected individuals involves the application of a diagnostic test to a population and adjusting according to test performance, sensitivity and specificity. Bayesian latent class analysis for the estimation of her... Read More about Low accuracy of Bayesian latent class analysis for estimation of herd-level true prevalence under certain disease characteristics—An analysis using simulated data.

Clinical audit in farm animal veterinary practice. Part 2: conducting the audit (2018)
Journal Article

This article, the second in a two-part series providing practical advice for practitioners on carrying out clinical audits in farm animal practice, focuses on the data collection, analysis and discussion steps of clinical audit. Part 1, which was pub... Read More about Clinical audit in farm animal veterinary practice. Part 2: conducting the audit.

Systematic review of the factors affecting cat and dog owner compliance with pharmaceutical treatment recommendations (2018)
Journal Article

© 2018 British Veterinary Association. The aim of this systematic review is to describe and assess the quality of the existing evidence base concerning factors that influence the compliance of cat and dog owners to pharmaceutical and specifically pol... Read More about Systematic review of the factors affecting cat and dog owner compliance with pharmaceutical treatment recommendations.

The Status of Pet Rabbit Breeding and Online Sales in the UK: A Glimpse into an Otherwise Elusive Industry (2018)
Journal Article

Conditions of pet rabbit breeding colonies and breeder practices are undocumented and very little is known about the pet rabbit sales market. Here, multiple methods were employed to investigate this sector of the UK pet industry. A freedom of informa... Read More about The Status of Pet Rabbit Breeding and Online Sales in the UK: A Glimpse into an Otherwise Elusive Industry.

Reviving Phage Therapy for the Treatment of Cholera (2018)
Journal Article

Cholera remains a major risk in developing countries, particularly after natural or man-made disasters. Vibrio cholerae El Tor is the most important cause of these outbreaks, and is becoming increasingly resistant to antibiotics, so alternative thera... Read More about Reviving Phage Therapy for the Treatment of Cholera.

Discovery of peptide ligands targeting a specific ubiquitin-like domain– binding site in the deubiquitinase USP11 (2018)
Journal Article

© 2019 Spiliotopoulos et al. Published by The American Society for Biochemistry and Molecular Biology, Inc. Ubiquitin-specific proteases (USPs) reverse ubiquitination and regulate virtually all cellular processes. Defined noncatalytic domains in USP... Read More about Discovery of peptide ligands targeting a specific ubiquitin-like domain– binding site in the deubiquitinase USP11.

The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program (2018)
Journal Article

Synthetic beta-adrenergic agonists (BA) have broad biomedical and agricultural application for increasing lean body mass, yet a poor understanding of the biology underpinning these agents is limiting further drug discovery potential. Growing female p... Read More about The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program.

Are nutraceuticals better than carprofen at controlling osteoarthritis in dogs? (2018)
Journal Article

Sally, a 12-year-old female neutered black Labrador, is presented to you with right forelimb lameness. She has decreased range of movement in both hips and the right elbow. You radiograph her hips, stifles, shoulders and elbows and find she has signi... Read More about Are nutraceuticals better than carprofen at controlling osteoarthritis in dogs?.

Feature selection and comparison of machine learning algorithms in classification of grazing and rumination behaviour in sheep (2018)
Journal Article

Grazing and ruminating are the most important behaviours for ruminants, as they spend most of their daily time budget performing these. Continuous surveillance of eating behaviour is an important means for monitoring ruminant health, productivity and... Read More about Feature selection and comparison of machine learning algorithms in classification of grazing and rumination behaviour in sheep.

Acute Toxoplasma gondii infection in cats induced tissue-specific transcriptional response dominated by immune signatures (2018)
Journal Article

RNA-sequencing was used to detect transcriptional changes in six tissues of cats, seven days after T. gondii infection. A total of 737 genes were differentially expressed (DEGs), of which 410 were up-regulated and 327 were down-regulated. The liver e... Read More about Acute Toxoplasma gondii infection in cats induced tissue-specific transcriptional response dominated by immune signatures.

Predicting puberty in partial androgen insensitivity syndrome: use of clinical and functional androgen receptor indices (2018)
Journal Article

Fasciola hepatica, TGF-β and host mimicry: the enemy within (2018)
Journal Article

Helminths parasites undergo developmental changes and migration within their definitive host, in addition to establishing chronic infection. Essential to this is the evasion of host immune responses; the canonical Th2 response is effective at removin... Read More about Fasciola hepatica, TGF-β and host mimicry: the enemy within.

Bio-inspired hierarchical designs for stiff, strong interfaces between materials of differing stiffness (2018)
Journal Article

Throughout biology, geometric hierarchy is a recurrent theme in structures where strength is achieved with efficient material usage. Acting over vast timescales, evolution has brought about beautiful solutions to problems of mechanics that are only n... Read More about Bio-inspired hierarchical designs for stiff, strong interfaces between materials of differing stiffness.

Associations between routinely collected dairy herd improvement data and insemination outcome in UK dairy herds (2018)
Journal Article

Milk constituent concentrations in samples taken during early lactation are often used to generate proxy measures for energy balance in dairy herds. This study aimed to explore associations between these and other measures routinely recorded by dairy... Read More about Associations between routinely collected dairy herd improvement data and insemination outcome in UK dairy herds.

Clinical audit in farm animal veterinary practice: Part 1: preparing for audit (2018)
Journal Article

This article, the first in a two-part series providing practical advice for practitioners on carrying out clinical audits, discusses the preparation and initiation of clinical audit in farm animal practice. In the second article, to be published in a... Read More about Clinical audit in farm animal veterinary practice: Part 1: preparing for audit.

Recent changes in infectious diseases in European wildlife (2018)
Journal Article

© Wildlife Disease Association 2019. Many infectious diseases originating from, or carried by, wildlife affect wildlife conservation and biodiversity, livestock health, or human health. We provide an update on changes in the epidemiology of 25 select... Read More about Recent changes in infectious diseases in European wildlife.