All Outputs (139)

Enhanced pathogenicity and neurotropism of mouse-adapted H10N7 influenza virus are mediated by novel PB2 and NA mutations (2017)
Journal Article

The H10 subtype of avian influenza viruses (AIVs) circulates globally in wild birds and poultry, and this subtype has been shown to be increasingly prevalent in China. Among the various H10 viruses, H10N7 AIVs have caused repeated mammal and human in... Read More about Enhanced pathogenicity and neurotropism of mouse-adapted H10N7 influenza virus are mediated by novel PB2 and NA mutations.

Contribution of flagella and motility to gut colonisation and pathogenicity of Salmonella Enteritidis in the chicken (2017)
Journal Article

Salmonella Enteritidis causes fowl paratyphoid in poultry and is frequently associated to outbreaks of food-borne diseases in humans. The role of flagella and flagella-mediated motility into host-pathogen interplay is not fully understood and require... Read More about Contribution of flagella and motility to gut colonisation and pathogenicity of Salmonella Enteritidis in the chicken.

Principles of early human development and germ cell program from conserved model systems (2017)
Journal Article

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during week 2-3 of early postimplantation development(1). Using in vitro models of hPGC induction(2-4), recent studies suggest striking mechanistic differences in specif... Read More about Principles of early human development and germ cell program from conserved model systems.

Proteomic differences between developmental stages of Toxoplasma gondii revealed by iTRAQ-based quantitative proteomics (2017)
Journal Article

Toxoplasma gondii has a complex two-host life-cycle between intermediate host and definitive host. Understanding proteomic variations across the life-cycle stages of T. gondii may improve the understanding of molecular adaption mechanism of T. gondii... Read More about Proteomic differences between developmental stages of Toxoplasma gondii revealed by iTRAQ-based quantitative proteomics.

Defining the ABC of gene essentiality in streptococci (2017)
Journal Article

Background: Utilising next generation sequencing to interrogate saturated bacterial mutant libraries provides unprecedented information for the assignment of genome-wide gene essentiality. Exposure of saturated mutant libraries to specific conditions... Read More about Defining the ABC of gene essentiality in streptococci.

An in vitro model for assessing effective scrapie decontamination (2017)
Journal Article

Scrapie infectivity enters the environment via a multiplicity of routes from infected animals. Environmentally associated scrapie persists on farms when infected animals have been removed and is particularly resistant to disinfection. Infectivity wit... Read More about An in vitro model for assessing effective scrapie decontamination.

Prediction of Streptococcus uberis clinical mastitis risk using Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) in dairy herds (2017)
Journal Article

The purpose of this study was to evaluate whether the risk of Streptococcus uberis clinical mastitis at cow level could be predicted from the historical presence of specific strains of S. uberis on dairy farms. Matrix-assisted laser desorption ioniza... Read More about Prediction of Streptococcus uberis clinical mastitis risk using Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) in dairy herds.

Molecular approaches to the diagnosis and monitoring of production diseases in pigs (2017)
Journal Article

Production disease in pigs is caused by a variety of different pathogens, mainly enteric and respiratory and can result in significant economic loss. Other factors such as stress, poor husbandry and nutrition can also contribute to an animal's suscep... Read More about Molecular approaches to the diagnosis and monitoring of production diseases in pigs.

Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI (2017)
Journal Article

N6-adenosine methylation (m6A) of mRNA is an essential process in most eukaryotes, but its role and the status of factors accompanying this modification are still poorly understood. Using combined methods of genetics, proteomics and RNA biochemis... Read More about Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI.

Safety culture: the Nottingham Veterinary Safety Culture Survey (NVSCS) (2017)
Journal Article

Safety culture is a vital concept in human healthcare because of its influence on staff behaviours in relation to patient safety. Understanding safety culture is essential to ensure the acceptance and sustainability of changes, such as the introducti... Read More about Safety culture: the Nottingham Veterinary Safety Culture Survey (NVSCS).

Preliminary investigation of urine N-telopeptide concentration as a biomarker of bone resorption in dogs receiving glucocorticoids: Urinary NTx in glucocorticoid treated dogs (2017)
Journal Article

Objectives The influence of glucocorticoid therapy on bone resorption in dogs using a urine N?telopeptide assay was investigated. Materials and Methods Thirty?one dogs receiving oral glucocorticoids and 31 age?matched healthy control dogs were e... Read More about Preliminary investigation of urine N-telopeptide concentration as a biomarker of bone resorption in dogs receiving glucocorticoids: Urinary NTx in glucocorticoid treated dogs.

How is Europe positioned for a re-emergence of Schmallenberg virus? (2017)
Journal Article

The Schmallenberg virus (SBV) caused a large scale epidemic in Europe from 2011–2013 infecting ruminants and causing fetal deformities after infection of pregnant animals. The main impacts of the virus were financial losses due to animal, meat and se... Read More about How is Europe positioned for a re-emergence of Schmallenberg virus?.

Effect of claw horn lesion type and severity at the time of treatment on outcome of lameness in dairy cows (2017)
Journal Article

Prompt diagnosis and treatment of claw horn lesions in cattle affects the likelihood of recovery; however, it is unknown if the type of lesion influences the likelihood of recovery. The aim of this study was to investigate whether the type, severity... Read More about Effect of claw horn lesion type and severity at the time of treatment on outcome of lameness in dairy cows.

A prospective cohort study of digital cushion and corium thickness, Part 2: does thinning of the digital cushion and corium lead to lameness and claw horn disruption lesions? (2017)
Journal Article

The aim of this study was to determine whether a decrease in thickness of the sole soft tissues (SST) beneath the flexor tuberosity of the distal phalanx (i.e. the digital cushion and corium) predisposed a claw to develop claw horn disruption lesions... Read More about A prospective cohort study of digital cushion and corium thickness, Part 2: does thinning of the digital cushion and corium lead to lameness and claw horn disruption lesions?.

A prospective cohort study of digital cushion and corium thickness, Part 1: associations with body condition, lesion incidence and proximity to calving (2017)
Journal Article

Claw horn disruption lesions (CHDL) are a major cause of lameness in dairy cattle and are likely a result of excessive forces being applied to the germinal epithelium that produces claw horn. The digital cushion is a connective tissue structure, cont... Read More about A prospective cohort study of digital cushion and corium thickness, Part 1: associations with body condition, lesion incidence and proximity to calving.

Retrospective evaluation of thoracic computed tomography ?ndings in dogs naturally infected by Angiostrongylus vasorum (2017)
Journal Article

Angiostrongylus vasorum (A. vasorum) is an important emerging disease of canidae. Cardiorespiratory signs are common in affected dogs, therefore thoracic imaging is critical for diagnosing andmonitoring disease. Descriptions of thoracic computed tomo... Read More about Retrospective evaluation of thoracic computed tomography ?ndings in dogs naturally infected by Angiostrongylus vasorum.

"She's a dog at the end of the day": guide dog owners' perspectives on the behaviour of their guide dog (2017)
Journal Article

A guide dog is a domestic dog (Canis familiaris) that is specifically educated to provide mobility support to a blind or visually impaired owner. Current dog suitability assessments focus on behavioural traits, including: trainability, reactivity or... Read More about "She's a dog at the end of the day": guide dog owners' perspectives on the behaviour of their guide dog.

Unbiased analysis of the impact of micropatterned biomaterials on macrophage behaviour provides insights beyond pre-defined polarisation states (2017)
Journal Article

Macrophages are master regulators of immune responses towards implanted biomaterials. The activation state adopted by macrophages in response to biomaterials determines their own phenotype and function as well as those of other resident and infiltrat... Read More about Unbiased analysis of the impact of micropatterned biomaterials on macrophage behaviour provides insights beyond pre-defined polarisation states.

Balancing responsibilities when prescribing antimicrobials for farm animals (2017)
Journal Article

Mathematical modeling of ovine footrot in the UK: the effect of Dichelobacter nodosus and Fusobacterium necrophorum on the disease dynamics (2017)
Journal Article

Dichelobacter nodosus is a virulent, invasive, anaerobic bacterium that is believed to be the causative agent of ovine footrot, an infectious bacterial disease of sheep that causes lameness. Another anaerobe, Fusobacterium necrophorum, has been intim... Read More about Mathematical modeling of ovine footrot in the UK: the effect of Dichelobacter nodosus and Fusobacterium necrophorum on the disease dynamics.