Preliminary investigation of urine N-telopeptide concentration as a biomarker of bone resorption in dogs receiving glucocorticoids: Urinary NTx in glucocorticoid treated dogs

Adamany, J. L.; Cross, G. F.; Gardner, D.S.; Dunning, M. D.

Abstract

Objectives
The influence of glucocorticoid therapy on bone resorption in dogs using a urine N?telopeptide assay was investigated.

Materials and Methods
Thirty?one dogs receiving oral glucocorticoids and 31 age?matched healthy control dogs were enrolled. Urine N?telopeptide concentration was measured using a commercially available immunoassay and results were expressed as a ratio against urinary creatinine concentration. Dogs receiving glucocorticoids were divided into three subgroups based on daily glucocorticoid dose and three subgroups based on treatment duration. Urine N?telopeptide concentration was then compared between groups.

Results
Urine N?telopeptide concentration was significantly higher in dogs receiving glucocorticoids compared to the control group.

Clinical Significance
This preliminary study demonstrates significant increase in urine N?telopeptide concentration in dogs receiving glucocorticoid therapy compared to control dogs. Further studies are needed to assess whether this increase in urine N?telopeptide concentration correlates with decreases in bone mineral density as has been identified in humans.

Citation

Adamany, J. L., Cross, G. F., Gardner, D., & Dunning, M. D. (2017). Preliminary investigation of urine N-telopeptide concentration as a biomarker of bone resorption in dogs receiving glucocorticoids: Urinary NTx in glucocorticoid treated dogs. Journal of Small Animal Practice, 58(7), 403-407. doi:10.1111/jsap.12675

• Journal Article Type: Article
• Acceptance Date: Dec 21, 2016
• Online Publication Date: May 3, 2017
• Publication Date: 2017-07
• Deposit Date: Nov 29, 2018
• Journal: Journal of Small Animal Practice
• Print ISSN: 0022-4510
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 58
• Issue: 7
• Pages: 403-407
• DOI: https://doi.org/10.1111/jsap.12675
• Public URL: https://nottingham-repository.worktribe.com/output/1340087
• Publisher URL: https://onlinelibrary.wiley.com/doi/full/10.1111/jsap.12675