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Preliminary investigation of urine N-telopeptide concentration as a biomarker of bone resorption in dogs receiving glucocorticoids: Urinary NTx in glucocorticoid treated dogs

Adamany, J. L.; Cross, G. F.; Gardner, D.S.; Dunning, M. D.

Authors

J. L. Adamany

G. F. Cross

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DAVID GARDNER DAVID.GARDNER@NOTTINGHAM.AC.UK
Professor of Physiology



Abstract

Objectives
The influence of glucocorticoid therapy on bone resorption in dogs using a urine N?telopeptide assay was investigated.

Materials and Methods
Thirty?one dogs receiving oral glucocorticoids and 31 age?matched healthy control dogs were enrolled. Urine N?telopeptide concentration was measured using a commercially available immunoassay and results were expressed as a ratio against urinary creatinine concentration. Dogs receiving glucocorticoids were divided into three subgroups based on daily glucocorticoid dose and three subgroups based on treatment duration. Urine N?telopeptide concentration was then compared between groups.

Results
Urine N?telopeptide concentration was significantly higher in dogs receiving glucocorticoids compared to the control group.

Clinical Significance
This preliminary study demonstrates significant increase in urine N?telopeptide concentration in dogs receiving glucocorticoid therapy compared to control dogs. Further studies are needed to assess whether this increase in urine N?telopeptide concentration correlates with decreases in bone mineral density as has been identified in humans.

Citation

Adamany, J. L., Cross, G. F., Gardner, D., & Dunning, M. D. (2017). Preliminary investigation of urine N-telopeptide concentration as a biomarker of bone resorption in dogs receiving glucocorticoids: Urinary NTx in glucocorticoid treated dogs. Journal of Small Animal Practice, 58(7), 403-407. doi:10.1111/jsap.12675

Journal Article Type Article
Acceptance Date Dec 21, 2016
Online Publication Date May 3, 2017
Publication Date 2017-07
Deposit Date Nov 29, 2018
Journal Journal of Small Animal Practice
Print ISSN 0022-4510
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 58
Issue 7
Pages 403-407
DOI https://doi.org/10.1111/jsap.12675
Public URL https://nottingham-repository.worktribe.com/output/1340087
Publisher URL https://onlinelibrary.wiley.com/doi/full/10.1111/jsap.12675