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All Outputs (1382)

Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression (2023)
Journal Article
Atallah, N. M., Haque, M., Quinn, C., Toss, M. S., Makhlouf, S., Ibrahim, A., …Rakha, E. (2023). Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression. European Journal of Cancer, 195, Article 113371. https://doi.org/10.1016/j.ejca.2023.113371

Background: Breast cancer (BC) expressing low levels of human epidermal growth factor receptor 2 (HER2 Low) is an emerging category that needs further refining. This study aims to provide a comprehensive clinico-pathological and molecular profile of... Read More about Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression.

Evidence of personality-dependent plasticity in dairy calf movement behaviours derived from automated data collection (2023)
Journal Article
Occhiuto, F., Vázquez-Diosdado, J. A., King, A. J., & Kaler, J. (2023). Evidence of personality-dependent plasticity in dairy calf movement behaviours derived from automated data collection. Scientific Reports, 13, Article 18243. https://doi.org/10.1038/s41598-023-44957-z

Individual consistency in behaviour, known as animal personality, and behavioural plasticity in response to environmental changes are important factors shaping individual behaviour. Correlations between them, called personality-dependent plasticity,... Read More about Evidence of personality-dependent plasticity in dairy calf movement behaviours derived from automated data collection.

Improving analgesia provision for sheep: An analysis of farm medicine records and attitudes towards pain relief on sheep farms in Northern Ireland (2023)
Journal Article
Crawford, P. E., Hamer, K., Lovatt, F., Behnke, M. C., & Robinson, P. A. (2023). Improving analgesia provision for sheep: An analysis of farm medicine records and attitudes towards pain relief on sheep farms in Northern Ireland. Veterinary Record Open, 10(2), Article e75. https://doi.org/10.1002/vro2.75

Background Management of pain is critical to improve the welfare of farmed livestock and meet consumer expectations. There is limited published information about the use of analgesic drugs in the sheep sector. Methods A mixed-method approach was... Read More about Improving analgesia provision for sheep: An analysis of farm medicine records and attitudes towards pain relief on sheep farms in Northern Ireland.

A newly characterized dense granule protein (GRA76) is important for the growth and virulence of Toxoplasma gondii (2023)
Journal Article
Zheng, X., Sun, L., Elsheikha, H. M., Li, T., Gao, J., Wu, X., …Wang, J. (2024). A newly characterized dense granule protein (GRA76) is important for the growth and virulence of Toxoplasma gondii. International Journal for Parasitology, 54(2), 109-121. https://doi.org/10.1016/j.ijpara.2023.09.001

Pathogenicity of the zoonotic pathogen Toxoplasma gondii largely depends on the secretion of effector proteins into the extracellular milieu and host cell cytosol, including the dense granule proteins (GRAs). The protein-encoding gene TGME49_299780 w... Read More about A newly characterized dense granule protein (GRA76) is important for the growth and virulence of Toxoplasma gondii.

Exploring the data divide through a social practice lens: A qualitative study of UK cattle farmers (2023)
Journal Article
Doidge, C., Palczynski, L., Zhou, X., Bearth, A., van Schaik, G., & Kaler, J. (2023). Exploring the data divide through a social practice lens: A qualitative study of UK cattle farmers. Preventive Veterinary Medicine, 220, Article 106030. https://doi.org/10.1016/j.prevetmed.2023.106030

Appropriate management decisions are key for sustainable and profitable beef and dairy farming. Data-driven technologies aim to provide information which can improve farmers’ decision-making practices. However, data-driven technologies have resulted... Read More about Exploring the data divide through a social practice lens: A qualitative study of UK cattle farmers.

Antiviral activity of salt-coated materials against SARS-CoV-2 (2023)
Journal Article
Coleman, C. M., Wang, B., Wang, Y., Tapia-Brito, E., Chen, Z., Riffat, J., …Ghaemmaghami, A. (2023). Antiviral activity of salt-coated materials against SARS-CoV-2. Access Microbiology, 5(9), Article 000492. https://doi.org/10.1099/acmi.0.000492.v5

The SARS-CoV-2 pandemic demonstrated the importance of human coronaviruses and the need to develop materials to prevent the spread of emergent respiratory viruses. Coating of surfaces with antiviral materials is a major interest in controlling spread... Read More about Antiviral activity of salt-coated materials against SARS-CoV-2.

Efficacy of Different Encapsulation Techniques on the Viability and Stability of Diverse Phage under Simulated Gastric Conditions (2023)
Journal Article
Dlamini, S. B., Gigante, A. M., Hooton, S. P. T., & Atterbury, R. J. (2023). Efficacy of Different Encapsulation Techniques on the Viability and Stability of Diverse Phage under Simulated Gastric Conditions. Microorganisms, 11(10), Article 2389. https://doi.org/10.3390/microorganisms11102389

Salmonella causes a range of diseases in humans and livestock of considerable public health and economic importance. Widespread antimicrobial use, particularly in intensively produced livestock (e.g., poultry and pigs) may contribute to the rise of m... Read More about Efficacy of Different Encapsulation Techniques on the Viability and Stability of Diverse Phage under Simulated Gastric Conditions.

Differential response of HER2-positive breast cancer to anti-HER2 therapy based on HER2 protein expression level (2023)
Journal Article
Atallah, N. M., Alsaleem, M., Toss, M. S., Mongan, N. P., & Rakha, E. (2023). Differential response of HER2-positive breast cancer to anti-HER2 therapy based on HER2 protein expression level. British Journal of Cancer, https://doi.org/10.1038/s41416-023-02426-4

Background: Increasing data indicate that HER2-positive (HER2 +) breast cancer (BC) subtypes exhibit differential responses to targeted anti-HER2 therapy. This study aims to investigate these differences and the potential underlying molecular mechani... Read More about Differential response of HER2-positive breast cancer to anti-HER2 therapy based on HER2 protein expression level.

Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses (2023)
Journal Article
Mohd Jaafar, F., Belhouchet, M., Monsion, B., Bell-Sakyi, L., Mertens, P. P. C., & Attoui, H. (2023). Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses. Viruses, 15(9), Article 1908. https://doi.org/10.3390/v15091908

Non-structural protein 4 (NS4) of insect-borne and tick-borne orbiviruses is encoded by genome segment 9, from a secondary open reading frame. Though a protein dispensable for bluetongue virus (BTV) replication, it has been shown to counter the inter... Read More about Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses.

Unravelling transmission of Mycobacterium avium subspecies paratuberculosis to dairy calves: results of a lifelong longitudinal study (2023)
Journal Article
Nunney, E., Crotta, M., van Winden, S., Bond, K., Green, M., & Guitian, J. (2023). Unravelling transmission of Mycobacterium avium subspecies paratuberculosis to dairy calves: results of a lifelong longitudinal study. Preventive Veterinary Medicine, 219, Article 106022. https://doi.org/10.1016/j.prevetmed.2023.106022

Johne's disease (JD) is a chronic disease of ruminants endemic in the UK and other countries and responsible for large economic losses for the dairy sector. JD is caused by Mycobacterium avium subspecies paratuberculosis (MAP), which typically infect... Read More about Unravelling transmission of Mycobacterium avium subspecies paratuberculosis to dairy calves: results of a lifelong longitudinal study.

Mapping Polyclonal Antibody Responses to Infection Using Next-Generation Phage Display (2023)
Book Chapter
Tsoumpeli, M. T., Varghese, A., Owen, J. P., Maddison, B. C., Daly, J. M., & Gough, K. C. (2023). Mapping Polyclonal Antibody Responses to Infection Using Next-Generation Phage Display. In M. Hust, & T. S. Lim (Eds.), Phage Display (467-487). Springer US. https://doi.org/10.1007/978-1-0716-3381-6_25

Peptide phage display has historically been used to epitope map monoclonal antibodies. More recently, by coupling this method with next-generation sequencing (so-called next-generation phage display, NGPD) to mass screen peptide binding events, the m... Read More about Mapping Polyclonal Antibody Responses to Infection Using Next-Generation Phage Display.

Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets (2023)
Journal Article
Sun, H., Li, H., Tong, Q., Han, Q., Liu, J., Yu, H., …Liu, J. (2023). Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets. Cell, 186(19), 4074-4084.e11. https://doi.org/10.1016/j.cell.2023.08.011

H3N8 avian influenza viruses (AIVs) in China caused two confirmed human infections in 2022, followed by a fatal case reported in 2023. H3N8 viruses are widespread in chicken flocks; however, the zoonotic features of H3N8 viruses are poorly understood... Read More about Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets.

Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep (2023)
Journal Article
Evans, N. P., Bellingham, M., Elcombe, C. S., Ghasemzadeh-Hasankolaei, M., Lea, R. G., Sinclair, K. D., & Padmanabhan, V. (2023). Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep. Environmental Toxicology and Pharmacology, 102, Article 104257. https://doi.org/10.1016/j.etap.2023.104257

Humans are ubiquitously exposed to complex mixtures of environmental chemicals (ECs). This study characterised changes in post-natal and peripubertal growth, and the activation of the reproductive axis, in male and female offspring of sheep exposed t... Read More about Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep.

Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish (2023)
Journal Article
Emeish, W. F. A., Fawaz, M. M., Hussein, N. M., Al-Amgad, Z., Abd-ElHafeez, H. H., Rutland, C. S., & Bakry, K. A. (2023). Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish. Microscopy and Microanalysis, 29(5), 1774-1790. https://doi.org/10.1093/micmic/ozad091

Henneguya species are myxozoans, a suborder of Cnidaria, which can affect the gills and extrarespiratory organs of the African sharptooth catfish, Clarias gariepinus. This research describes natural infection-induced histological alterations caused b... Read More about Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish.

Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer (2023)
Journal Article
Wong, K., Abascal, F., Ludwig, L., Aupperle-Lellbach, H., Grassinger, J., Wright, C. W., …van der Weyden, L. (2023). Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer. Genome Biology, 24(1), Article 191. https://doi.org/10.1186/s13059-023-03026-4

Background: In humans, muscle-invasive bladder cancer (MIBC) is highly aggressive and associated with a poor prognosis. With a high mutation load and large number of altered genes, strategies to delineate key driver events are necessary. Dogs and cat... Read More about Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer.

Social and ethical implications of data and technology use on farms: a qualitative study of Swedish dairy and pig farmers (2023)
Journal Article
Doidge, C., Frössling, J., C. Dórea, F., Ordell, A., Vidal, G., & Kaler, J. (2023). Social and ethical implications of data and technology use on farms: a qualitative study of Swedish dairy and pig farmers. Frontiers in Veterinary Science, 10, Article 1171107. https://doi.org/10.3389/fvets.2023.1171107

Introduction: Livestock farmers are being increasingly encouraged to adopt digital health technologies on their farms. Digital innovations may have unintended consequences, but there tends to be a pro-innovation bias in previous literature. This... Read More about Social and ethical implications of data and technology use on farms: a qualitative study of Swedish dairy and pig farmers.

Mental wellbeing and psychosocial working conditions of autistic veterinary surgeons in the UK (2023)
Journal Article
Smits, F., Houdmont, J., Hill, B., & Pickles, K. (2023). Mental wellbeing and psychosocial working conditions of autistic veterinary surgeons in the UK. Veterinary Record, 193(8), Article e3311. https://doi.org/10.1002/vetr.3311

Background: Certain autistic characteristics (such as hyper-focus and attention to detail) are valued by veterinary surgeons and autistic adults may disproportionately self-select into the profession. Links between mental wellbeing and retention in t... Read More about Mental wellbeing and psychosocial working conditions of autistic veterinary surgeons in the UK.

Heart ventricles of the dromedary camel (Camelus dromedarius): new insights from sectional anatomy, 3D computed tomography, and morphometry (2023)
Journal Article
Alsafy, M. A., El-Gendy, S. A., Kamal, B. M., Rutland, C. S., Abd-Elhafeez, H. H., Soliman, S., …Nomir, A. G. (2023). Heart ventricles of the dromedary camel (Camelus dromedarius): new insights from sectional anatomy, 3D computed tomography, and morphometry. BMC Zoology, 8, Article 12. https://doi.org/10.1186/s40850-023-00173-w

Dromedary camel heart morphology is a crucial research topic with clinical applications. The study aims to understand the dromedary camel anatomy, morphology, and architecture of the ventricular mass. Results: Sagittal and transverse gross sections w... Read More about Heart ventricles of the dromedary camel (Camelus dromedarius): new insights from sectional anatomy, 3D computed tomography, and morphometry.

A model of antibiotic resistance genes accumulation through lifetime exposure from food intake and antibiotic treatment (2023)
Journal Article
Todman, H., Arya, S., Baker, M., & Stekel, D. J. (2023). A model of antibiotic resistance genes accumulation through lifetime exposure from food intake and antibiotic treatment. PLoS ONE, 18(8), Article e0289941. https://doi.org/10.1371/journal.pone.0289941

Antimicrobial resistant bacterial infections represent one of the most serious contemporary global healthcare crises. Acquisition and spread of resistant infections can occur through community, hospitals, food, water or endogenous bacteria. Global ef... Read More about A model of antibiotic resistance genes accumulation through lifetime exposure from food intake and antibiotic treatment.