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All Outputs (101)

Isolation and Characterization of a Novel Phage Collection against Avian-Pathogenic Escherichia coli (2023)
Journal Article
Nicolas, M., Trotereau, A., Culot, A., Moodley, A., Atterbury, R., Wagemans, J., …Schouler, C. (2023). Isolation and Characterization of a Novel Phage Collection against Avian-Pathogenic Escherichia coli. Microbiology Spectrum, 11(3), Article e04296-22. https://doi.org/10.1128/spectrum.04296-22

The increase in antibiotic-resistant avian-pathogenic Escherichia coli (APEC), the causative agent of colibacillosis in poultry, warrants urgent research and the development of alternative therapies. This study describes the isolation and characteriz... Read More about Isolation and Characterization of a Novel Phage Collection against Avian-Pathogenic Escherichia coli.

Targeting DNA damage repair precision medicine strategies in cancer (2023)
Journal Article
Brownlie, J., Kulkarni, S., Algethami, M., Jeyapalan, J. N., Mongan, N. P., Rakha, E. A., & Madhusudan, S. (2023). Targeting DNA damage repair precision medicine strategies in cancer. Current Opinion in Pharmacology, 70, Article 102381. https://doi.org/10.1016/j.coph.2023.102381

DNA repair targeted therapeutics is a promising precision medicine strategy in cancer. The development and clinical use of PARP inhibitors has transformed lives for many patients with BRCA germline deficient breast and ovarian cancer as well as plati... Read More about Targeting DNA damage repair precision medicine strategies in cancer.

Temporal trends in equine sperm progressive motility: a systematic review and meta-regression (2023)
Journal Article
Harris, I. T., Maddock, C., Farnworth, M., Nankervis, K., Perrett, J., Pyatt, A. Z., & Blanchard, R. N. (2023). Temporal trends in equine sperm progressive motility: a systematic review and meta-regression. Reproduction, 165(6), M1–M10. https://doi.org/10.1530/REP-22-0490

In brief: Adverse trends in reproductive function are a concern in humans, companion, livestock, and wildlife species. This study indicates that equine populations are at risk of a comparable decline in sperm progressive motility. Abstract: There is... Read More about Temporal trends in equine sperm progressive motility: a systematic review and meta-regression.

The antioxidant protein glutaredoxin 1 is essential for oxidative stress response and pathogenicity of Toxoplasma gondii (2023)
Journal Article
Li, T., Zhao, D., Liang, Q., Elsheikha, H. M., Wang, M., Sun, L., …Wang, J. (2023). The antioxidant protein glutaredoxin 1 is essential for oxidative stress response and pathogenicity of Toxoplasma gondii. The FASEB Journal, 37(6), Article e22932. https://doi.org/10.1096/fj.202201275r

Glutaredoxins (Grxs) are ubiquitous antioxidant proteins involved in many molecular processes to protect cells against oxidative damage. Here, we study the roles of Grxs in the pathogenicity of Toxoplasma gondii. We show that Grxs are localized in th... Read More about The antioxidant protein glutaredoxin 1 is essential for oxidative stress response and pathogenicity of Toxoplasma gondii.

A Prospective Cohort Study Investigating the Impact of Neutering Bitches Prepubertally or Post-Pubertally on Physical Development (2023)
Journal Article
Moxon, R., Freeman, S. L., Payne, R., Godfrey-Hunt, J., Corr, S., & England, G. C. W. (2023). A Prospective Cohort Study Investigating the Impact of Neutering Bitches Prepubertally or Post-Pubertally on Physical Development. Animals, 13(9), Article 1431. https://doi.org/10.3390/ani13091431

No previous large prospective cohort studies have been identified that have investigated the impact of the surgical neutering of bitches before or after known puberty on their growth and physical development. This study was designed to examine the da... Read More about A Prospective Cohort Study Investigating the Impact of Neutering Bitches Prepubertally or Post-Pubertally on Physical Development.

Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease (2023)
Journal Article
Grove, J. I., Lo, P. C., Shrine, N., Barwell, J., Wain, L. V., Tobin, M. D., …Aithal, G. P. (2023). Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease. JHEP Reports, 5(8), Article 100764. https://doi.org/10.1016/j.jhepr.2023.100764

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a complex trait with an estimated prevalence of 25% globally. We aimed to identify the genetic variant underlying a four-generation family with progressive NAFLD leading to cirrhosis, de... Read More about Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease.

Increased Clinical Signs and Mortality in IFNAR(−/−) Mice Immunised with the Bluetongue Virus Outer-Capsid Proteins VP2 or VP5, after Challenge with an Attenuated Heterologous Serotype (2023)
Journal Article
Attoui, H., Mohd Jaafar, F., Monsion, B., Klonjkowski, B., Reid, E., Fay, P. C., …Mertens, P. P. C. (2023). Increased Clinical Signs and Mortality in IFNAR(−/−) Mice Immunised with the Bluetongue Virus Outer-Capsid Proteins VP2 or VP5, after Challenge with an Attenuated Heterologous Serotype. Pathogens, 12(4), Article 602. https://doi.org/10.3390/pathogens12040602

Bluetongue is an economically important disease of domesticated and wild ruminants caused by bluetongue virus (BTV). There are at least 36 different serotypes of BTV (the identity of which is determined by its outer-capsid protein VP2), most of which... Read More about Increased Clinical Signs and Mortality in IFNAR(−/−) Mice Immunised with the Bluetongue Virus Outer-Capsid Proteins VP2 or VP5, after Challenge with an Attenuated Heterologous Serotype.

Small non-coding RNA landscape of extracellular vesicles from an experimental model of equine osteoarthritis (2023)
Journal Article
Peffers, M., Anderson, J., Jacobsen, S., Walters, M., Bundgaard, L., Hackle, M., & James, V. (2023). Small non-coding RNA landscape of extracellular vesicles from an experimental model of equine osteoarthritis. Orthopaedic Proceedings, 105-B(SUPP_8), 119-119. https://doi.org/10.1302/1358-992x.2023.8.119

Joint tissues release extracellular vesicles (EVs) that potentially sustain joint homeostasis and contribute to osteoarthritis (OA) pathogenesis. EVs are putative novel therapeutics for OA, and transport biologically active molecules (including small... Read More about Small non-coding RNA landscape of extracellular vesicles from an experimental model of equine osteoarthritis.

Unravelling Strain-Specific Modifications of Toxoplasma gondii tRNA and sncRNA Using LC-MS/MS (2023)
Journal Article
Wang, W., Yang, Y., Guo, H., Li, M. H., Chen, X. Q., Wei, X. Y., …Zhang, X. X. (2023). Unravelling Strain-Specific Modifications of Toxoplasma gondii tRNA and sncRNA Using LC-MS/MS. Microbiology Spectrum, 11(3), Article e0356422. https://doi.org/10.1128/spectrum.03564-22

Many RNA modifications have been detected in rRNA, tRNA and small noncoding RNA (sncRNA) as well as in low-abundance RNA species such mRNA. Although RNA modifications play roles in many cellular and biological processes in various domains of life, kn... Read More about Unravelling Strain-Specific Modifications of Toxoplasma gondii tRNA and sncRNA Using LC-MS/MS.

Identification of Orbivirus Non-Structural Protein 5 (NS5), Its Role and Interaction with RNA/DNA in Infected Cells (2023)
Journal Article
Mohd Jaafar, F., Monsion, B., Mertens, P. P., & Attoui, H. (2023). Identification of Orbivirus Non-Structural Protein 5 (NS5), Its Role and Interaction with RNA/DNA in Infected Cells. International Journal of Molecular Sciences, 24(7), Article 6845. https://doi.org/10.3390/ijms24076845

Bioinformatic analyses have predicted that orbiviruses encode an additional, small non-structural protein (NS5) from a secondary open reading frame on genome segment 10. However, this protein has not previously been detected in infected mammalian or... Read More about Identification of Orbivirus Non-Structural Protein 5 (NS5), Its Role and Interaction with RNA/DNA in Infected Cells.

PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model (2023)
Journal Article
Gomez, N. E., James, V., Arkill, K. P., Nizamudeen, Z. A., Onion, D., & Fairclough, L. C. (2023). PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model. European Journal of Immunology, 53(6), Article 2250143. https://doi.org/10.1002/eji.202250143

Extracellular vesicles (EVs) function as mediators of intercellular communication and as such influence the recipient cell function. EVs derived from immune cells can carry out many of the same functions as their parental cells, as they carry costimu... Read More about PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model.

Effect of neutering timing in relation to puberty on female dog behaviour—A scoping review (2023)
Journal Article
Moxon, R., Freeman, S. L., Payne, R., Corr, S., & England, G. C. W. (2023). Effect of neutering timing in relation to puberty on female dog behaviour—A scoping review. Veterinary Record, 193(1), Article e2882. https://doi.org/10.1002/vetr.2882

Background There are contradictory findings in the literature relating to the effects of timing of neutering on bitch behaviour that make decision making regarding neutering timing difficult. Methods A scoping review was designed to identify an... Read More about Effect of neutering timing in relation to puberty on female dog behaviour—A scoping review.

A multistate modeling approach to investigate long-term effects of claw horn disruption lesions and early lesion development in dairy cows (2023)
Journal Article
Thomas, M., Green, M., Kypraios, T., & Kaler, J. (2023). A multistate modeling approach to investigate long-term effects of claw horn disruption lesions and early lesion development in dairy cows. Journal of Dairy Science, https://doi.org/10.3168/jds.2021-21749

Claw horn disruption lesions (CHDL) are a leading cause of lameness in dairy cattle, and the development, effect, and pathology of these lesions remains an open area of interest within dairy cattle health. Current literature typically attempts to mea... Read More about A multistate modeling approach to investigate long-term effects of claw horn disruption lesions and early lesion development in dairy cows.

Data from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent (2023)
Dataset
Martini, R., Delpe, P., Chu, T. R., Arora, K., Lord, B., Verma, A., …Davis, M. B. (2023). Data from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent. [Dataset]. https://doi.org/10.1158/2159-8290.c.6549760.v1

Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers (2023)
Journal Article
Algethami, M., Toss, M. S., Woodcock, C. L., Jaipal, C., Brownlie, J., Shoqafi, A., …Madhusudan, S. (2023). Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers. npj Breast Cancer, 9, Article 18. https://doi.org/10.1038/s41523-023-00524-3

Replication Protein A (RPA), a heterotrimeric complex consisting of RPA1, 2, and 3 subunits, is a single-stranded DNA (ssDNA)-binding protein that is critically involved in replication, checkpoint regulation and DNA repair. Here we have evaluated RPA... Read More about Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers.

Modulation of long noncoding RNA (lncRNA) and messenger RNA (mRNA) expression in the liver of Beagle dogs by Toxocara canis infection (2023)
Journal Article
Zou, Y., Zheng, W. B., Elsheikha, H. M., He, J. J., Lu, Y. X., Wang, S., …Zhu, X. Q. (2023). Modulation of long noncoding RNA (lncRNA) and messenger RNA (mRNA) expression in the liver of Beagle dogs by Toxocara canis infection. Parasites and Vectors, 16, Article 114. https://doi.org/10.1186/s13071-023-05738-9

Background Long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) play crucial roles in regulating various physiological and pathological processes. However, the role of lncRNAs and mRNAs in mediating the liver response during Toxocara canis infec... Read More about Modulation of long noncoding RNA (lncRNA) and messenger RNA (mRNA) expression in the liver of Beagle dogs by Toxocara canis infection.

Longitudinal study of antimicrobial use patterns, vaccination and disease prevalence in British sheep flocks (2023)
Journal Article
Davies, P. L., Hyde, R. M., & Lovatt, F. M. (2023). Longitudinal study of antimicrobial use patterns, vaccination and disease prevalence in British sheep flocks. Veterinary Record, 193(2), Article e2786. https://doi.org/10.1002/vetr.2786

Background: The aim of the study was to describe the longitudinal dynamics of antimicrobial use (AMU) on sheep farms and explore associations between AMU and management factors, vaccination strategies, reproductive performance and prevalence of lamen... Read More about Longitudinal study of antimicrobial use patterns, vaccination and disease prevalence in British sheep flocks.

Use of qualitative behavioural assessment to investigate affective states of housed dairy cows under different environmental conditions (2023)
Journal Article
Russell, A. L., Randall, L. V., Kaler, J., Eyre, N., & Green, M. J. (2023). Use of qualitative behavioural assessment to investigate affective states of housed dairy cows under different environmental conditions. Frontiers in Veterinary Science, 10, Article 1099170. https://doi.org/10.3389/fvets.2023.1099170

In addition to the reduction of suboptimal welfare, there is now a need to provide farmed animals with positive opportunities to provide confidence that they have experienced a life worth living. Diversification of the environment through environment... Read More about Use of qualitative behavioural assessment to investigate affective states of housed dairy cows under different environmental conditions.

Topographic anatomy and vascularization of the glandula thyroidea in rats (2023)
Journal Article
Nur, I. H., Pérez, W., & Rutland, C. S. (2023). Topographic anatomy and vascularization of the glandula thyroidea in rats. Anatomia, Histologia, Embryologia, 52(4), 571-582. https://doi.org/10.1111/ahe.12916

Topographical anatomy and detailed measurements of the glandula thyroidea (thyroid gland) and the glandula parathyroidea (parathyroid gland) were determined in rats, with significant differences identified between the sexes. In the rats (N=10 male, 1... Read More about Topographic anatomy and vascularization of the glandula thyroidea in rats.