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Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study (2018)
Journal Article
Anand-Ivell, R., Cohen, A., Norgaard-Pedersen, B., Joenssen, B., Bonde, J., Hougaard, D. M., …Ivell, R. (2018). Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study. Frontiers in Physiology, 9, Article 408. https://doi.org/10.3389/fphys.2018.00406

The period of the first to second trimester transition in human pregnancy represents a sensitive window for fetal organogenesis, particularly in regard to the development of the male reproductive system. This is a time of relative analytical inaccess... Read More about Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study.

Application of multiple behaviour change models to identify determinants of farmers’ biosecurity attitudes and behaviours (2018)
Journal Article
Richens, I., Houdmont, J., Wapenaar, W., Shortall, O., Kaler, J., O’Connor, H., & Brennan, M. L. (2018). Application of multiple behaviour change models to identify determinants of farmers’ biosecurity attitudes and behaviours. Preventive Veterinary Medicine, 155, https://doi.org/10.1016/j.prevetmed.2018.04.010

It has been recognised that few cattle farmers undertake biosecurity practices on their farms. Approaches that take into consideration individuals’ preparedness for change, alongside beliefs thought to motivate the enactment of certain behaviours, ma... Read More about Application of multiple behaviour change models to identify determinants of farmers’ biosecurity attitudes and behaviours.

The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host (2018)
Journal Article
Calvo-Pinilla, E., Gubbins, S., Mertens, P. P., Ortego, J., & Castillo-Olivares, J. (2018). The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host. Antiviral Research, 154, https://doi.org/10.1016/j.antiviral.2018.04.015

African horse sickness (AHS) is a lethal equine disease transmitted by Culicoides biting midges and caused by African horse sickness virus (AHSV). AHS is endemic to sub-Saharan Africa, but devastating outbreaks have been recorded periodically outside... Read More about The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host.

Live-attenuated Pru: Δcdpk2 strain of Toxoplasma gondii protects against acute, chronic and congenital toxoplasmosis (2018)
Journal Article
Wang, J., Li, T., Elsheikha, H. M., Chen, K., Cong, W., Yang, W., …Zhu, X. (2018). Live-attenuated Pru: Δcdpk2 strain of Toxoplasma gondii protects against acute, chronic and congenital toxoplasmosis. Journal of Infectious Diseases, 218(5), 768–777. https://doi.org/10.1093/infdis/jiy211

Background: The threat of Toxoplasma gondii infection in immunocompromised individuals and pregnant women necessitates the development of a safe and effective vaccine. Here, we examined the immune protection conferred by live-attenuated strain of T.... Read More about Live-attenuated Pru: Δcdpk2 strain of Toxoplasma gondii protects against acute, chronic and congenital toxoplasmosis.

Associations between dairy cow inter-service interval and probability of conception (2018)
Journal Article
Remnant, J., Green, M., Huxley, J., & Hudson, C. (2018). Associations between dairy cow inter-service interval and probability of conception. Theriogenology, 114, 324-329. https://doi.org/10.1016/j.theriogenology.2018.03.029

Recent research has indicated that the interval between inseminations in modern dairy cattle is often longer than the commonly accepted cycle length of 18–24 days. This study analysed 257,396 inseminations in 75,745 cows from 312 herds in England and... Read More about Associations between dairy cow inter-service interval and probability of conception.

Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses (2018)
Journal Article
Slater, T., Eckerle, I., & Chang, K. (2018). Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses. Virology Journal, 15, Article 68. https://doi.org/10.1186/s12985-018-0979-6

Background With the recent discovery of novel H17N10 and H18N11 influenza viral RNA in bats and report on high frequency of avian H9 seroconversion in a species of free ranging bats, an important issue to address is the extent bats are susceptible... Read More about Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses.

Holographic optical trapping Raman micro-spectroscopy for interacting live cells (2018)
Working Paper
Sinjab, F., Elsheikha, H. M., Awuah, D., Gibson, G., Padgett, M., Ghaemmaghami, A. M., & Notingher, I. Holographic optical trapping Raman micro-spectroscopy for interacting live cells

We present a combined holographic optical tweezers and confocal Raman spectroscopy instrument which allows fast, flexible, and interactive manipulation with molecular measurement of interacting live cell systems. Multiple laser foci created using a s... Read More about Holographic optical trapping Raman micro-spectroscopy for interacting live cells.

Motivators and barriers for dog and cat owners and veterinary surgeons in the United Kingdom to using preventative medicines (2018)
Journal Article
Belshaw, Z., Robinson, N. J., Dean, R. S., & Brennan, M. L. (2018). Motivators and barriers for dog and cat owners and veterinary surgeons in the United Kingdom to using preventative medicines. Preventive Veterinary Medicine, 154, https://doi.org/10.1016/j.prevetmed.2018.03.020

Routine use of preventative medicines is advocated as part of responsible dog and cat ownership. However, it has been suggested that the number of owners in the United Kingdom (UK) using preventative medicines to protect their pets is in decline. The... Read More about Motivators and barriers for dog and cat owners and veterinary surgeons in the United Kingdom to using preventative medicines.

The applied development of a tiered multilocus sequence typing (MLST) scheme for Dichelobacter nodosus (2018)
Journal Article
Blanchard, A. M., Jolley, K. A., Maiden, M. C., Coffey, T. J., Maboni, G., Staley, C. E., …Tötemeyer, S. (in press). The applied development of a tiered multilocus sequence typing (MLST) scheme for Dichelobacter nodosus. Frontiers in Microbiology, 9, Article 551. https://doi.org/10.3389/fmicb.2018.00551

Dichelobacter nodosus (D. nodosus) is the causative pathogen of ovine footrot, a disease that has a significant welfare and financial impact on the global sheep industry. Previous studies into the phylogenetics of D. nodosus have focused on Australia... Read More about The applied development of a tiered multilocus sequence typing (MLST) scheme for Dichelobacter nodosus.

Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy (2018)
Journal Article
Saad, N., Alberio, R., Johnson, A. D., Emes, R. D., Giles, T. C., Clarke, P., …Allegrucci, C. (2018). Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy. Oncotarget, 9(22), 16008-16027. https://doi.org/10.18632/oncotarget.24664

Inducing stable control of tumour growth by tumour reversion is an alternative approach to cancer treatment when eradication of the disease cannot be achieved. The process requires re-establishment of normal control mechanisms that are lost in canc... Read More about Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy.

Application of mesenchymal stem cells for therapeutic agent delivery in anti-tumor treatment (2018)
Journal Article
Chulpanoval, D. S., Kitaeva, K. V., Tazetdinoval, L. G., James, V., Rizvanov, A. A., & Solovyeval, V. V. (2018). Application of mesenchymal stem cells for therapeutic agent delivery in anti-tumor treatment. Frontiers in Pharmacology, 9, Article 259. https://doi.org/10.3389/fphar.2018.00259

Mesenchymal stem cells (MSCs) are non-hematopoietic progenitor cells, which can be isolated from different types of tissues including bone marrow, adipose tissue, tooth pulp, and placenta/umbilical cord blood. There isolation from adult tissues circu... Read More about Application of mesenchymal stem cells for therapeutic agent delivery in anti-tumor treatment.

A step in the right direction: an open-design pedometer algorithm for dogs (2018)
Journal Article
Ladha, C., Belshaw, Z., O’Sullivan, J., & Asher, L. (2018). A step in the right direction: an open-design pedometer algorithm for dogs. BMC Veterinary Research, 14, Article 107. https://doi.org/10.1186/s12917-018-1422-3

Accelerometer-based technologies could be useful in providing objective measures of canine ambulation, but most are either not tailored to the idiosyncrasies of canine gait, or, use un-validated or closed source approaches. The aim of this paper was... Read More about A step in the right direction: an open-design pedometer algorithm for dogs.

Opsonic phagocytosis in chronic obstructive pulmonary disease is enhanced by Nrf2 agonists (2018)
Journal Article
Bewley, M. A., Budd, R. C., Ryan, E., Cole, J., Collini, P., Marshall, J., …Dockrell, D. H. (in press). Opsonic phagocytosis in chronic obstructive pulmonary disease is enhanced by Nrf2 agonists. American Journal of Respiratory and Critical Care Medicine, https://doi.org/10.1164/rccm.201705-0903OC

Rationale: Previous studies have identified defects in bacterial phagocytosis by alveolar macrophages (AM) in patients with chronic obstructive pulmonary disease (COPD) but the mechanisms and clinical consequences remain incompletely defined. Object... Read More about Opsonic phagocytosis in chronic obstructive pulmonary disease is enhanced by Nrf2 agonists.

Measuring the success of specific health problem consultations in cats and dogs: a systematic review (2018)
Journal Article
Corah, L., Mossop, L., Cobb, K., & Dean, R. (in press). Measuring the success of specific health problem consultations in cats and dogs: a systematic review. Veterinary Record, https://doi.org/10.1136/vr.104759

Consultations are complex interactions, are central to achieving optimal outcomes for all stakeholders, yet what constitutes a successful consultation has not been defined. The aim of this systematic review was to describe the scope of the literature... Read More about Measuring the success of specific health problem consultations in cats and dogs: a systematic review.

The challenges posed by equine arboviruses (2018)
Journal Article
Chapman, G. E., Baylis, M., Archer, D., & Daly, J. M. (2018). The challenges posed by equine arboviruses. Equine Veterinary Journal, 50(4), 436-445. https://doi.org/10.1111/evj.12829

Equine populations worldwide are at increasing risk of infection by viruses transmitted by biting arthropods including mosquitoes, biting midges (Culicoides), sandflies and ticks. These include the flaviviruses (Japanese encephalitis, West Nile and M... Read More about The challenges posed by equine arboviruses.

A recombinant Fasciola gigantica 14-3-3 epsilon protein (rFg14-3-3e) modulates various functions of goat peripheral blood mononuclear cells (2018)
Journal Article
Tian, A., Lu, M., Calderón-Mantilla, G., Petsalaki, E., Dottorini, T., Tian, X., …Zhu, X. (2018). A recombinant Fasciola gigantica 14-3-3 epsilon protein (rFg14-3-3e) modulates various functions of goat peripheral blood mononuclear cells. Parasites and Vectors, 11(1), https://doi.org/10.1186/s13071-018-2745-4

Background The molecular structure of Fasciola gigantica 14-3-3 protein has been characterized. However, the involvement of this protein in parasite pathogenesis remains elusive and its effect on the functions of innate immune cells is unknown. We... Read More about A recombinant Fasciola gigantica 14-3-3 epsilon protein (rFg14-3-3e) modulates various functions of goat peripheral blood mononuclear cells.

Identification of two novel host proteins interacting with Toxoplasma gondii 14-3-3 protein by yeast two-hybrid system (2018)
Journal Article
Li, F., Liu, Q., Elsheikha, H. M., Yang, W., Hou, J., & Zhu, X. (in press). Identification of two novel host proteins interacting with Toxoplasma gondii 14-3-3 protein by yeast two-hybrid system. Parasitology Research, https://doi.org/10.1007/s00436-018-5812-z

Toxoplasma gondii deploys many effector proteins in order to hijack and manipulate host cell signaling pathways, allowing parasite colonization, subversion of immune responses, and disease progression. T. gondii effector protein 14-3-3 (Tg14-3-3) pro... Read More about Identification of two novel host proteins interacting with Toxoplasma gondii 14-3-3 protein by yeast two-hybrid system.

Outcomes of conservatively managed coracoid fractures in wild birds in the United Kingdom (2018)
Journal Article
Cracknell, J. M., Lawrie, A. M., Yon, L., Hopper, J. S., Pereira, Y. M., Smaller, E., & Pizzi, R. (2018). Outcomes of conservatively managed coracoid fractures in wild birds in the United Kingdom. Journal of Avian Medicine and Surgery, 32(1), https://doi.org/10.1647/2016-195

Coracoid fractures are a frequent presentation in wild birds, commonly due to collisions with motor vehicles, windows, or other obstacles such as pylons. Despite this, there are few literature reports of outcomes, and those published consist of small... Read More about Outcomes of conservatively managed coracoid fractures in wild birds in the United Kingdom.

Overcoming potential barriers to investigating and treating myxomatous mitral valve disease (2018)
Journal Article
Belshaw, Z. (2018). Overcoming potential barriers to investigating and treating myxomatous mitral valve disease. In Practice, 40(Suppl), https://doi.org/10.1136/inp.k916

Achieving a diagnosis of mitral valve disease (MMVD) can be relatively straightforward. Persuading owners to investigate and treat, and then maintaining adherence to a therapeutic regimen can be significantly more challenging. While heart murmurs are... Read More about Overcoming potential barriers to investigating and treating myxomatous mitral valve disease.

Facilitating ecosystem assembly: plant-soil interactions as a restoration tool (2018)
Journal Article
van der Bij, A., Weijters, M., Robbink, R., Harris, J., Pawlett, M., Ritz, K., …van Diggelen, R. (2018). Facilitating ecosystem assembly: plant-soil interactions as a restoration tool. Biological Conservation, 220, https://doi.org/10.1016/j.biocon.2018.02.010

Although plant-soil interactions are increasingly recognized as an important factor in ecosystem restoration, their effects on community assembly during de novo ecosystem establishment are largely unknown. In a heathland restoration trial after topso... Read More about Facilitating ecosystem assembly: plant-soil interactions as a restoration tool.