All Outputs (139)

Development and evaluation of real time RT-PCR assays for detection and typing of Bluetongue virus (2016)
Journal Article
Richard, Y., Maan, S., Maan, N. S., Belaganahalli, M. N., Potgieter, A. C., Kumar, V., …Mertens, P. P. (2016). Development and evaluation of real time RT-PCR assays for detection and typing of Bluetongue virus. PLoS ONE, 11(9), Article e0163014. https://doi.org/10.1371/journal.pone.0163014

Bluetongue virus is the type species of the genus Orbivirus, family Reoviridae. Bluetongue viruses (BTV) are transmitted between their vertebrate hosts primarily by biting midges (Culicoides spp.) in which they also replicate. Consequently BTV distri... Read More about Development and evaluation of real time RT-PCR assays for detection and typing of Bluetongue virus.

TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants (2016)
Journal Article
Michael, S., Lindsey, F., Katelyn, M., Sravanthi, C., Lisa, Y., Nigel P, M., …Vincent J, L. (2016). TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants. eLife, 5, Article e11994. https://doi.org/10.7554/eLife.11994.001

A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here... Read More about TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants.

TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants (2016)
Journal Article
Sulak, M., Fong, L., Mika, K., Chigurupati, S., Yon, L., Mongan, N. P., …Lynch, V. J. (2016). TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants. eLife, 5(2016), Article e11994. https://doi.org/10.7554/eLife.11994.001

A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here... Read More about TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants.

The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants Emulsigen® and the monomeric TLR5 ligand FliC in zebu cattle against AlHV-1 malignant catarrhal fever induced by experimental virus challenge (2016)
Journal Article
Lankester, F., Lugelo, A., Werling, D., Mnyambwa, N., Keyyu, J., Kazwala, R., …Haig, D. (2016). The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants Emulsigen® and the monomeric TLR5 ligand FliC in zebu cattle against AlHV-1 malignant catarrhal fever induced by experimental virus challenge. Veterinary Microbiology, 195, 144-153. https://doi.org/10.1016/j.vetmic.2016.09.019

Malignant catarrhal fever (MCF) is a fatal disease of cattle that, in East Africa, follows contact with wildebeest excreting alcelaphine herpesvirus 1 (AlHV-1). Recently an attenuated vaccine (atAlHV-1) was tested under experimental challenge on Frie... Read More about The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants Emulsigen® and the monomeric TLR5 ligand FliC in zebu cattle against AlHV-1 malignant catarrhal fever induced by experimental virus challenge.

Factors influencing veterinary surgeons’ decision-making about dairy cattle vaccination (2016)
Journal Article
Richens, I., Hobson-West, P., Brennan, M. L., Hood, Z., Kaler, J., Green, M., …Wapenaar, W. (in press). Factors influencing veterinary surgeons’ decision-making about dairy cattle vaccination. Veterinary Record, 179(16), https://doi.org/10.1136/vr.103822

The use of vaccines in the cattle industry is widespread; however, there is limited published guidance for use by decision-makers such as farmers and vets. To best support vets in advising dairy farmers on the optimisation of vaccination strategies,... Read More about Factors influencing veterinary surgeons’ decision-making about dairy cattle vaccination.

A Bayesian micro-simulation to evaluate the cost-effectiveness of interventions for mastitis control during the dry period in UK dairy herds (2016)
Journal Article
Down, P., Bradley, A., Breen, J., Browne, W., Kypraios, T., & Green, M. (2016). A Bayesian micro-simulation to evaluate the cost-effectiveness of interventions for mastitis control during the dry period in UK dairy herds. Preventive Veterinary Medicine, 133, 64-72. https://doi.org/10.1016/j.prevetmed.2016.09.012

Importance of the dry period with respect to mastitis control is now well established although the precise interventions that reduce the risk of acquiring intramammary infections during this time are not clearly understood. There are very few interve... Read More about A Bayesian micro-simulation to evaluate the cost-effectiveness of interventions for mastitis control during the dry period in UK dairy herds.

Multimodal assessment of estrogen receptor mRNA profiles to quantify estrogen pathway activity in breast tumors (2016)
Journal Article
Muthukaruppan, A., Lasham, A., Woad, K. J., Black, M. A., Blenkiron, C., Miller, L. D., …Print, C. G. (2017). Multimodal assessment of estrogen receptor mRNA profiles to quantify estrogen pathway activity in breast tumors. Clinical Breast Cancer, 17(2), https://doi.org/10.1016/j.clbc.2016.09.001

Background Molecular markers have transformed our understanding of the heterogeneity of breast cancer and have allowed the identification of genomic profiles of estrogen receptor (ER)-? signaling. However, our understanding of the transcriptional... Read More about Multimodal assessment of estrogen receptor mRNA profiles to quantify estrogen pathway activity in breast tumors.

Lameness in dairy heifers; impacts of hoof lesions present around first calving on future lameness, milk yield and culling risk (2016)
Journal Article
Randall, L., Green, M. J., Chagunda, M., Mason, C., Green, L., & Huxley, J. (in press). Lameness in dairy heifers; impacts of hoof lesions present around first calving on future lameness, milk yield and culling risk. Preventive Veterinary Medicine, 133, https://doi.org/10.1016/j.prevetmed.2016.09.006

The importance of lameness in primiparous dairy heifers is increasingly recognised. Although it is accepted that clinical lameness in any lactation increases the risk of future lameness, the impact of foot lesions during the first lactation on long-t... Read More about Lameness in dairy heifers; impacts of hoof lesions present around first calving on future lameness, milk yield and culling risk.

Acanthamoeba castellanii : A new high-throughput method for drug screening in vitro (2016)
Journal Article
Ortega-Rivas, A., Padrón, J. M., Valladares, B., & Elsheikha, H. M. (2016). Acanthamoeba castellanii : A new high-throughput method for drug screening in vitro. Acta Tropica, 164, 95-99. https://doi.org/10.1016/j.actatropica.2016.09.006

Despite significant public health impact, there is no specific antiprotozoal therapy for prevention and treatment of Acanthamoeba castellanii infection. There is a need for new and efficient anti-Acanthamoeba drugs that are less toxic and can reduce... Read More about Acanthamoeba castellanii : A new high-throughput method for drug screening in vitro.

Ovine footrot: new insights into bacterial colonisation (2016)
Journal Article
Maboni, G., Frosth, S., Aspán, A., & Tötemeyer, S. (2016). Ovine footrot: new insights into bacterial colonisation. Veterinary Record, 179(9), Article 228. https://doi.org/10.1136/vr.103610

Ovine footrot is characterised by interdigital dermatitis (ID) and by the separation of the skin and hoof horn (under-running footrot). Dichelobacter nodosus is the essential pathogen causing footrot; the role of other microorganisms in this disease... Read More about Ovine footrot: new insights into bacterial colonisation.

The influenza NS1 protein: what do we know in equine influenza virus pathogenesis? (2016)
Journal Article
Barba, M., & Daly, J. M. (2016). The influenza NS1 protein: what do we know in equine influenza virus pathogenesis?. Pathogens, 5(3), Article 57. https://doi.org/10.3390/pathogens5030057

Equine influenza virus remains a serious health and potential economic problem throughout most parts of the world, despite intensive vaccination programs in some horse populations. The influenza non-structural protein 1 (NS1) has multiple functions i... Read More about The influenza NS1 protein: what do we know in equine influenza virus pathogenesis?.

Targeted suppression of AR-V7 using PIP5K1? inhibitor overcomes enzalutamide resistance in prostate cancer cells (2016)
Journal Article
Sarwar, M., Semenas, J., Miftakhova, R., Simoulis, A., Robinson, B., Wingren, A. G., …Persson, J. L. (2016). Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells. Oncotarget, 7(39), 63065-63081. https://doi.org/10.18632/oncotarget.11757

One mechanism of resistance of prostate cancer (PCa) to enzalutamide (MDV3100) treatment is the increased expression of AR variants lacking the ligand binding-domain, the best characterized of which is AR-V7. We have previously reported that Phosphat... Read More about Targeted suppression of AR-V7 using PIP5K1? inhibitor overcomes enzalutamide resistance in prostate cancer cells.

Ostertagia spp., rumen fluke and liver fluke single- and poly-infections in cattle: an abattoir study of prevalence and production impacts in England and Wales (2016)
Journal Article
Bellet, C., Green, M. J., Vickers, M., Forbes, A., Berry, J., & Kaler, J. (in press). Ostertagia spp., rumen fluke and liver fluke single- and poly-infections in cattle: an abattoir study of prevalence and production impacts in England and Wales. Preventive Veterinary Medicine, 132, https://doi.org/10.1016/j.prevetmed.2016.08.010

This study aims at investigating the occurrence, risk factors and production impacts on beef carcassparameters of three of the most important cattle helminth infections in England and Wales. Abomasa, reticulorumens and livers from healthy cattle were... Read More about Ostertagia spp., rumen fluke and liver fluke single- and poly-infections in cattle: an abattoir study of prevalence and production impacts in England and Wales.

Detection of a Yersinia pestisgene homologue in rodent samples (2016)
Journal Article
Giles, T. A., Greenwood, A. D., Tsangaras, K., Giles, T. C., Barrow, P. A., Hannant, D., …Yon, L. (2016). Detection of a Yersinia pestisgene homologue in rodent samples. PeerJ, 4, Article e2216. https://doi.org/10.7717/peerj.2216

A homologue to a widely used genetic marker, pla, for Yersinia pestis has been identified in tissue samples of two species of rat (Rattus rattus and Rattus norvegicus) and of mice (Mus musculus and Apodemus sylvaticus) using a microarray based platfo... Read More about Detection of a Yersinia pestisgene homologue in rodent samples.

‘Disperse abroad in the land’: the role of wildlife in the dissemination of antimicrobial resistance (2016)
Journal Article
Arnold, K. E., Williams, N. J., & Bennett, M. (2016). ‘Disperse abroad in the land’: the role of wildlife in the dissemination of antimicrobial resistance. Biology Letters, 12(8), Article 0137. https://doi.org/10.1098/rsbl.2016.0137

Antimicrobial resistance (AMR) has been detected in the microbiota of many wildlife species, including long-distance migrants. Inadequately treated wastes from humans and livestock dosed with antimicrobial drugs are often assumed to be the main sourc... Read More about ‘Disperse abroad in the land’: the role of wildlife in the dissemination of antimicrobial resistance.

Oxytocin versus carbetocin administered to cows after uncomplicated calvings and subsequent fertility (2016)
Journal Article
Robinson, N., & Brennan, M. L. (2016). Oxytocin versus carbetocin administered to cows after uncomplicated calvings and subsequent fertility. Veterinary Record, 179(7), https://doi.org/10.1136/vr.i3834

BestBETs for Vets are generated by the Centre for Evidence-based Veterinary Medicine at the University of Nottingham to help answer specific questions and assist in clinical decision making. Although evidence is often limited, they aim to find, prese... Read More about Oxytocin versus carbetocin administered to cows after uncomplicated calvings and subsequent fertility.

Mapping B-cell responses to Salmonella enterica serovars Typhimurium and Enteritidis in chickens for the discrimination of infected from vaccinated animals (2016)
Journal Article
Naqid, I. A., Owen, J. P., Maddison, B. C., Spiliotopoulos, A., Emes, R. D., Warry, A., …Gough, K. C. (2016). Mapping B-cell responses to Salmonella enterica serovars Typhimurium and Enteritidis in chickens for the discrimination of infected from vaccinated animals. Scientific Reports, 6, Article 31186. https://doi.org/10.1038/srep31186

Serological surveillance and vaccination are important strategies for controlling infectious diseases of food production animals. However, the compatibility of these strategies is limited by a lack of assays capable of di erentiating infected from va... Read More about Mapping B-cell responses to Salmonella enterica serovars Typhimurium and Enteritidis in chickens for the discrimination of infected from vaccinated animals.

Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism (2016)
Journal Article
Lea, R. G., Byers, A. S., Sumner, R. N., Rhind, S. M., Zhang, Z., Freeman, S. L., …England, G. C. (2016). Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism. Scientific Reports, 6(1), Article 31281. https://doi.org/10.1038/srep31281

Adverse temporal trends in human semen quality and cryptorchidism in infants have been associated with exposure to environmental chemicals (ECs) during development. Here we report that a population of breeding dogs exhibit a 26 year (1988–2014) decli... Read More about Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism.

Subacute ruminal acidosis reduces sperm quality in beef bulls (2016)
Journal Article
Callaghan, M., McAuliffe, P., Rodgers, R., Hernandez-Medrano, J., & Perry, V. (in press). Subacute ruminal acidosis reduces sperm quality in beef bulls. Journal of Animal Science, 94, https://doi.org/10.2527/jas.2015-0235

Breeding bulls are commonly fed high-energy diets, which may induce subacute ruminal acidosis (SARA). In this experiment, 8 Santa Gertrudis bulls (age 20 ± 6 mo) were used to evaluate the extent and duration of effects of SARA on semen quality and th... Read More about Subacute ruminal acidosis reduces sperm quality in beef bulls.

Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection (2016)
Journal Article
He, J., Ma, J., Elsheikha, H. M., Song, H., Huang, S., & Zhu, X. (2016). Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection. Parasites and Vectors, 9(1), Article 427. https://doi.org/10.1186/s13071-016-1716-x

Background Toxoplasma gondii is a worldwide spread pathogen which can infect all tissues of its host. The transcriptomic responses of infected brain and spleen have been reported. However, our knowledge of the global transcriptomic change in infec... Read More about Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection.