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The progesterone receptor antagonist, onapristone has differential effects on the timing and control of the luteolytic mechanism depending on timing of administration in sheep (2013)
Journal Article
Mann, G., Wathes, D., & Robinson, R. (2013). The progesterone receptor antagonist, onapristone has differential effects on the timing and control of the luteolytic mechanism depending on timing of administration in sheep. Molecular and Cellular Endocrinology, 376(1-2), 1-11. doi:10.1016/j.mce.2013.06.001

Cyclic ewes were treated with control vehicle or progesterone receptor antagonist (onapristone; 100 mg i.m. twice daily) during either early (day 3–5) or late (day 12–14) luteal phase and plasma samples collected for hormone analysis and to determine... Read More about The progesterone receptor antagonist, onapristone has differential effects on the timing and control of the luteolytic mechanism depending on timing of administration in sheep.

A method of determining RNA conformational ensembles using structure-based calculations of residual dipolar couplings (2013)
Journal Article
Borkar, A. N., De Simone, A., Montalvao, R. W., & Vendruscolo, M. (2013). A method of determining RNA conformational ensembles using structure-based calculations of residual dipolar couplings. Journal of Chemical Physics, 138(21), Article 215103. https://doi.org/10.1063/1.4804301

We describe a method of determining the conformational fluctuations of RNA based on the incorporation of nuclear magnetic resonance (NMR) residual dipolar couplings (RDCs) as replica-averaged structural restraints in molecular dynamics simulations. I... Read More about A method of determining RNA conformational ensembles using structure-based calculations of residual dipolar couplings.

Association between somatic cell count early in the first lactation and the longevity of Irish dairy cows (2013)
Journal Article
Archer, S. C., Mc Coy, F., Wapenaar, W., & Green, M. J. (2013). Association between somatic cell count early in the first lactation and the longevity of Irish dairy cows. Journal of Dairy Science, 96(5), https://doi.org/10.3168/jds.2012-6115

Reduced longevity of cows is an important component of mastitis costs, and increased somatic cell count (SCC) early in the first lactation has been reported to increase culling risk throughout the first lactation. Generally, cows must survive beyond... Read More about Association between somatic cell count early in the first lactation and the longevity of Irish dairy cows.

Effect of extended cefquinome treatment on clinical persistence or recurrence of environmental clinical mastitis (2013)
Journal Article
Swinkels, J., Lam, T., Green, M. J., & Bradley, A. J. (2013). Effect of extended cefquinome treatment on clinical persistence or recurrence of environmental clinical mastitis. Veterinary Journal, 197(3), https://doi.org/10.1016/j.tvjl.2013.03.010

The effectiveness of antibiotic treatment of clinical mastitis (CM) is classically evaluated using bacteriological cure, which provides a concise and objective way of assessing efficacy but does not reflect the situation in the field where persistenc... Read More about Effect of extended cefquinome treatment on clinical persistence or recurrence of environmental clinical mastitis.

How does reviewing the evidence change veterinary surgeons’ beliefs regarding the treatment of ovine footrot?: a quantitative and qualitative study (2013)
Journal Article
Higgins, H. M., Green, L. E., Green, M. J., & Kaler, J. (2013). How does reviewing the evidence change veterinary surgeons’ beliefs regarding the treatment of ovine footrot?: a quantitative and qualitative study. PLoS ONE, 8(5), Article 13. https://doi.org/10.1371/journal.pone.0064175

Footrot is a widespread, infectious cause of lameness in sheep, with major economic and welfare costs. The aims of this research were: (i) to quantify how veterinary surgeons’ beliefs regarding the efficacy of two treatments for footrot changed follo... Read More about How does reviewing the evidence change veterinary surgeons’ beliefs regarding the treatment of ovine footrot?: a quantitative and qualitative study.

The role of proton dynamics in the development and maintenance of multidrug resistance in cancer (2013)
Journal Article
Daniel, C., Bell, C., Burton, C., Harguindey, S., Reshkinc, S. J., & Rauch, C. (2013). The role of proton dynamics in the development and maintenance of multidrug resistance in cancer. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1832(5), https://doi.org/10.1016/j.bbadis.2013.01.020

With a projected 382.4 per 100,000 people expected to suffer from some form of malignant neoplasm in 2015, improving treatment is an essential focus of cancer research today. Multi-drug resistance (MDR) is the leading cause of chemotherapeutic failur... Read More about The role of proton dynamics in the development and maintenance of multidrug resistance in cancer.

Using hormones to manage dairy cow fertility: the clinical and ethical beliefs of veterinary practitioners (2013)
Journal Article
Higgins, H. M., Ferguson, E., Smith, R. F., & Green, M. J. (2013). Using hormones to manage dairy cow fertility: the clinical and ethical beliefs of veterinary practitioners. PLoS ONE, 8(4), Article 9. https://doi.org/10.1371/journal.pone.0062993

In the face of a steady decline in dairy cow fertility over several decades, using hormones to assist reproduction has become common. In the European Union, hormones are prescription-only medicines, giving veterinary practitioners a central role in t... Read More about Using hormones to manage dairy cow fertility: the clinical and ethical beliefs of veterinary practitioners.

Cattle producers’ perceptions of biosecurity (2013)
Journal Article
Brennan, M. L., & Christley, R. M. (2013). Cattle producers’ perceptions of biosecurity. BMC Veterinary Research, 9(April), Article 8. https://doi.org/10.1186/1746-6148-9-71

Background: The limited use of biosecurity practices by many in the farming community is likely to be due to a range of factors; further understanding of this issue is required. In this study, attitudes and behaviours of producers relating to selecte... Read More about Cattle producers’ perceptions of biosecurity.

Characterisation of a group of endogenous gammaretroviruses in the canine genome (2013)
Journal Article
Tarlinton, R. E., Barfoot, H. K., Allen, C. E., Brown, K., Gifford, R. J., & Emes, R. D. (2013). Characterisation of a group of endogenous gammaretroviruses in the canine genome. Veterinary Journal, 196(1), https://doi.org/10.1016/j.tvjl.2012.08.011

Bioinformatics were used to identify and characterise 39 pol, 34 gag and five env gammaretroviruses within the canine (Canis lupus familiaris) reference genome. These endogenous retroviruses are monophyletic to the Canidae, predate the divergence of... Read More about Characterisation of a group of endogenous gammaretroviruses in the canine genome.

Evolution of equine influenza virus in vaccinated horses (2013)
Journal Article
Murcia, P. R., Baillie, G. J., Stack, J. C., Jervis, C., Elton, D., Mumford, J. A., …Wood, J. L. (2013). Evolution of equine influenza virus in vaccinated horses. Journal of Virology, 87(8), https://doi.org/10.1128/JVI.03379-12

Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in... Read More about Evolution of equine influenza virus in vaccinated horses.

Fleas and smaller fleas: virotherapy for parasite infections (2013)
Journal Article
Hyman, P., Atterbury, R. J., & Barrow, P. (2013). Fleas and smaller fleas: virotherapy for parasite infections. Trends in Microbiology, 21(5), https://doi.org/10.1016/j.tim.2013.02.006

Bacteriophages are viruses of bacteria that are used for controlling bacterial food-borne pathogens and have been proposed for more extensive usage in infection control. Protists are now recognised to harbour viruses and virus-like particles. We prop... Read More about Fleas and smaller fleas: virotherapy for parasite infections.

Association between somatic cell count early in the first lactation and the lifetime milk yield of cows in Irish dairy herds (2013)
Journal Article
Archer, S. C., Mc Coy, F., Wapenaar, W., & Green, M. J. (2013). Association between somatic cell count early in the first lactation and the lifetime milk yield of cows in Irish dairy herds. Journal of Dairy Science, 96(5), 2951-2959. https://doi.org/10.3168/jds.2012-6294

Change in lifetime milk yield is an important component of the cost of diseases in dairy cows. Knowledge of the likelihood and scale of potential savings through disease prevention measures is important to evaluate how much expenditure on control mea... Read More about Association between somatic cell count early in the first lactation and the lifetime milk yield of cows in Irish dairy herds.

Detection of porcine circovirus type 2 and viral replication by in situ hybridization in primary lymphoid organs from naturally and experimentally infected pigs (2013)
Journal Article
Hansen, M., Segales, J., Fernandes, L., Grau-Roma, L., Bille-Hansen, V., Larsen, L., & Nielsen, O. (in press). Detection of porcine circovirus type 2 and viral replication by in situ hybridization in primary lymphoid organs from naturally and experimentally infected pigs. Veterinary Pathology, 50(6), https://doi.org/10.1177/0300985813480805

Porcine circovirus type 2 (PCV2) infection is the cause of postweaning multisystemic wasting syndrome (PMWS). It has been speculated whether cell types permissive of replication are found in the primary lymphoid organs and whether infection of these... Read More about Detection of porcine circovirus type 2 and viral replication by in situ hybridization in primary lymphoid organs from naturally and experimentally infected pigs.

Benzamil sensitive ion channels contribute to volume regulation in canine chondrocytes (2013)
Journal Article
Lewis, R., Feetham, C., Gentles, L., Penny, J., Tregilgas, L., Tohami, W., …Barrett-Jolley, R. (2013). Benzamil sensitive ion channels contribute to volume regulation in canine chondrocytes. British Journal of Pharmacology, 168(7), https://doi.org/10.1111/j.1476-5381.2012.02185.x

Background and Purpose: Chondrocytes exist within cartilage and serve to maintain the extracellular matrix. It has been postulated that osteoarthritic (OA) chondrocytes lose the ability to regulate their volume, affecting extracellular matrix product... Read More about Benzamil sensitive ion channels contribute to volume regulation in canine chondrocytes.

Storage and release of spermatozoa from the pre-uterine tube reservoir (2013)
Journal Article
Freeman, S., & England, G. C. (2013). Storage and release of spermatozoa from the pre-uterine tube reservoir. PLoS ONE, 8(2), Article e57006. https://doi.org/10.1371/journal.pone.0057006

In mammals, after coitus a small number of spermatozoa enter the uterine tube and following attachment to uterine tube epithelium are arrested in a non-capacitated state until peri-ovulatory signalling induces their detachment. Whilst awaiting releas... Read More about Storage and release of spermatozoa from the pre-uterine tube reservoir.

Effects of Neospora caninum infection on brain microvascular endothelial cells bioenergetics (2013)
Journal Article
Elsheikha, H. M., McKinlay, C. L., Elsaied, N. A., & Smith, P. A. (2013). Effects of Neospora caninum infection on brain microvascular endothelial cells bioenergetics. Parasites and Vectors, 6(24), https://doi.org/10.1186/1756-3305-6-24

Background: The brain is the most commonly affected organ during Neospora caninum infection but the mechanisms utilized by this protozoan parasite for traversal of the blood–brain barrier (BBB) are not yet understood. Herein, we investigate the cellu... Read More about Effects of Neospora caninum infection on brain microvascular endothelial cells bioenergetics.

The incidence of feline injection site sarcomas in the United Kingdom (2013)
Journal Article
Dean, R. S., Pfeiffer, D. U., & Adams, V. J. (2013). The incidence of feline injection site sarcomas in the United Kingdom. BMC Veterinary Research, 9(Januar), Article 6. https://doi.org/10.1186/1746-6148-9-17

Background Feline injection site sarcomas (FISS) are aggressive neoplasms that have been associated with vaccination. In North America the incidence estimates have varied from 1 case of FISS per 1,000-10,000 cats vaccinated. The aim of this study... Read More about The incidence of feline injection site sarcomas in the United Kingdom.

Temporal associations between low body condition, lameness and milk yield in a UK dairy herd (2013)
Journal Article
Green, L., Huxley, J., Banks, C., & Green, M. J. (2014). Temporal associations between low body condition, lameness and milk yield in a UK dairy herd. Preventive Veterinary Medicine, 113(1), https://doi.org/10.1016/j.prevetmed.2013.10.009

Previous work has hypothesised that cows in low body condition become lame. We tested this in a prospective longitudinal study. Body condition score (BCS), causes of lameness and milk yield were collected from a 600-cow herd over 44-months. Mixed eff... Read More about Temporal associations between low body condition, lameness and milk yield in a UK dairy herd.

Analysing the hidden curriculum: use of a cultural web (2013)
Journal Article
Mossop, L., Dennick, R., Hammond, R., & Robbé, I. (2013). Analysing the hidden curriculum: use of a cultural web. Medical Education, 47(2), https://doi.org/10.1111/medu.12072

CONTEXT Major influences on learning about medical professionalism come from the hidden curriculum. These influences can contribute positively or negatively towards the professional enculturation of clinical students. The fact that there is no valid... Read More about Analysing the hidden curriculum: use of a cultural web.