Evolution of equine influenza virus in vaccinated horses

Murcia, Pablo R.; Baillie, Gregory J.; Stack, J. Conrad; Jervis, Carley; Elton, Debra; Mumford, Jennifer A.; Daly, Janet M.; Kellam, Paul; Grenfell, Bryan T.; Holmes, Edward C.; Wood, James L.N.

Abstract

Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naive horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.

Citation

Murcia, P. R., Baillie, G. J., Stack, J. C., Jervis, C., Elton, D., Mumford, J. A., Daly, J. M., Kellam, P., Grenfell, B. T., Holmes, E. C., & Wood, J. L. (2013). Evolution of equine influenza virus in vaccinated horses. Journal of Virology, 87(8), https://doi.org/10.1128/JVI.03379-12

• Journal Article Type: Article
• Publication Date: Apr 1, 2013
• Deposit Date: Jun 26, 2015
• Publicly Available Date: Jun 26, 2015
• Journal: Journal of Virology
• Print ISSN: 0022-538X
• Electronic ISSN: 1098-5514
• Publisher: American Society for Microbiology
• Peer Reviewed: Peer Reviewed
• Volume: 87
• Issue: 8
• DOI: https://doi.org/10.1128/JVI.03379-12
• Keywords: horses, equine influenza, vaccines, vaccination, pathogens
• Public URL: https://nottingham-repository.worktribe.com/output/713531
• Publisher URL: http://jvi.asm.org/content/87/8/4768.full