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Evolution of equine influenza virus in vaccinated horses

Murcia, Pablo R.; Baillie, Gregory J.; Stack, J. Conrad; Jervis, Carley; Elton, Debra; Mumford, Jennifer A.; Daly, Janet M.; Kellam, Paul; Grenfell, Bryan T.; Holmes, Edward C.; Wood, James L.N.

Authors

Pablo R. Murcia

Gregory J. Baillie

J. Conrad Stack

Carley Jervis

Debra Elton

Jennifer A. Mumford

Janet M. Daly

Paul Kellam

Bryan T. Grenfell

Edward C. Holmes

James L.N. Wood



Abstract

Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naive horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.

Journal Article Type Article
Publication Date Apr 1, 2013
Journal Journal of Virology
Print ISSN 0022-538X
Electronic ISSN 0022-538X
Publisher American Society for Microbiology
Peer Reviewed Peer Reviewed
Volume 87
Issue 8
APA6 Citation Murcia, P. R., Baillie, G. J., Stack, J. C., Jervis, C., Elton, D., Mumford, J. A., …Wood, J. L. (2013). Evolution of equine influenza virus in vaccinated horses. Journal of Virology, 87(8), doi:10.1128/JVI.03379-12
DOI https://doi.org/10.1128/JVI.03379-12
Keywords horses, equine influenza, vaccines, vaccination, pathogens
Publisher URL http://jvi.asm.org/content/87/8/4768.full
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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