All Outputs (2275)

Sustained morphine exposure alters spinal NMDA receptor and astrocyte expression and exacerbates chronic pain behavior in female rats (2024)
Journal Article
Gonçalves, S. V., Woodhams, S. G., Li, L., Hathway, G. J., & Chapman, V. (2024). Sustained morphine exposure alters spinal NMDA receptor and astrocyte expression and exacerbates chronic pain behavior in female rats. PAIN Reports, 9(2), Article e1145. https://doi.org/10.1097/pr9.0000000000001145

IntroductionSustained opioid use has long-term negative impacts on future pain experience, particularly in women. This study aimed to investigate the underlying spinal neurobiology of this clinical observation in an experimental model of joint pain.O... Read More about Sustained morphine exposure alters spinal NMDA receptor and astrocyte expression and exacerbates chronic pain behavior in female rats.

Rising water temperature in rivers: Ecological impacts and future resilience (2024)
Journal Article
Johnson, M. F., Albertson, L. K., Algar, A. C., Dugdale, S. J., Edwards, P., England, J., …Wood, P. J. (2024). Rising water temperature in rivers: Ecological impacts and future resilience. Wiley Interdisciplinary Reviews: Water, Article e1724. https://doi.org/10.1002/wat2.1724

Rising water temperatures in rivers due to climate change are already having observable impacts on river ecosystems. Warming water has both direct and indirect impacts on aquatic life, and further aggravates pervasive issues such as eutrophication, p... Read More about Rising water temperature in rivers: Ecological impacts and future resilience.

A genomic toolkit for winged bean Psophocarpus tetragonolobus (2024)
Journal Article
Ho, W. K., Tanzi, A. S., Sang, F., Tsoutsoura, N., Shah, N., Moore, C., …Mayes, S. (2024). A genomic toolkit for winged bean Psophocarpus tetragonolobus. Nature Communications, 15(1), Article 1901. https://doi.org/10.1038/s41467-024-45048-x

A sustainable supply of plant protein is critical for future generations and needs to be achieved while reducing green house gas emissions from agriculture and increasing agricultural resilience in the face of climate volatility. Agricultural diversi... Read More about A genomic toolkit for winged bean Psophocarpus tetragonolobus.

Two novel species of arctic-alpine lichen-forming fungi (Ascomycota, Megasporaceae) from the Deosai Plains, Pakistan (2024)
Journal Article
Usman, M., Dyer, P. S., Brock, M., Wade, C. M., & Khalid, A. N. (2024). Two novel species of arctic-alpine lichen-forming fungi (Ascomycota, Megasporaceae) from the Deosai Plains, Pakistan. MycoKeys, 102, 285-299. https://doi.org/10.3897/mycokeys.102.113310

Members of the lichen-forming fungal genus Oxneriaria are known to occur in cold polar and high altitudinal environments. Two new species, Oxneriaria crittendenii and O. deosaiensis, are now described from the high altitude Deosai Plains, Pakistan, b... Read More about Two novel species of arctic-alpine lichen-forming fungi (Ascomycota, Megasporaceae) from the Deosai Plains, Pakistan.

Blood donation screening for hepatitis B virus core antibodies: The importance of confirmatory testing and initial implication for rare blood donor groups (2024)
Journal Article
Fu, M. X., Ingram, J., Roberts, C., Nurmi, V., Watkins, E., Dempsey, N., …Harvala, H. (2024). Blood donation screening for hepatitis B virus core antibodies: The importance of confirmatory testing and initial implication for rare blood donor groups. Vox Sanguinis, https://doi.org/10.1111/vox.13608

Background and Objectives Exclusion of blood donors with hepatitis B virus (HBV) core antibodies (anti-HBc) prevents transfusion-transmitted HBV infection but can lead to significant donor loss. As isolated anti-HBc positivity does not always indica... Read More about Blood donation screening for hepatitis B virus core antibodies: The importance of confirmatory testing and initial implication for rare blood donor groups.

Effect of deletion of the protein kinase PRKD1 on development of the mouse embryonic heart (2024)
Journal Article
Waheed‐Ullah, Q., Wilsdon, A., Abbad, A., Rochette, S., Bu'Lock, F., Hitz, M., …Loughna, S. (2024). Effect of deletion of the protein kinase PRKD1 on development of the mouse embryonic heart. Journal of Anatomy, https://doi.org/10.1111/joa.14033

Congenital heart disease (CHD) is the most common congenital anomaly, with an overall incidence of approximately 1% in the United Kingdom. Exome sequencing in large CHD cohorts has been performed to provide insights into the genetic aetiology of CHD.... Read More about Effect of deletion of the protein kinase PRKD1 on development of the mouse embryonic heart.

Sex and age affect depot expression of Ca2+ channels in rat white fat adipocytes (2024)
Journal Article
Meng, Y., Toledo-Rodriguez, M., Fedorenko, O. A., & Smith, P. A. (2024). Sex and age affect depot expression of Ca2+ channels in rat white fat adipocytes. Journal of Molecular Endocrinology, 72(4), Article e230108. https://doi.org/10.1530/JME-23-0108

White adipose tissue (WAT) requires extracellular Ca2+ influx for lipolysis, differentiation, and expansion. This partly occurs via plasma membrane Ca2+ voltage-dependent channels (CaVs). However, WFA exists in different depots whose function varies... Read More about Sex and age affect depot expression of Ca2+ channels in rat white fat adipocytes.

Triblock copolymer micelles enhance solubility, permeability and activity of a quorum sensing inhibitor against Pseudomonas aeruginosa biofilms (2024)
Journal Article
Kasza, K., Soukarieh, F., Romero, M., Hardie, K. R., Gurnani, P., Cámara, M., & Alexander, C. (2024). Triblock copolymer micelles enhance solubility, permeability and activity of a quorum sensing inhibitor against Pseudomonas aeruginosa biofilms. RSC Applied Polymers, https://doi.org/10.1039/D3LP00208J

Antimicrobial resistance is a threat to public health for which new treatments are urgently required. The capability of bacteria to form biofilms is of particular concern as it enables high bacterial tolerance to conventional therapies by reducing dr... Read More about Triblock copolymer micelles enhance solubility, permeability and activity of a quorum sensing inhibitor against Pseudomonas aeruginosa biofilms.

Toxicological Aspects Associated with Consumption from Electronic Nicotine Delivery System (ENDS): Focus on Heavy Metals Exposure and Cancer Risk (2024)
Journal Article
Granata, S., Vivarelli, F., Morosini, C., Canistro, D., Paolini, M., & Fairclough, L. C. (2024). Toxicological Aspects Associated with Consumption from Electronic Nicotine Delivery System (ENDS): Focus on Heavy Metals Exposure and Cancer Risk. International Journal of Molecular Sciences, 25(5), Article 2737. https://doi.org/10.3390/ijms25052737

Tobacco smoking remains one of the leading causes of premature death worldwide. Electronic Nicotine Delivery Systems (ENDSs) are proposed as a tool for smoking cessation. In the last few years, a growing number of different types of ENDSs were launch... Read More about Toxicological Aspects Associated with Consumption from Electronic Nicotine Delivery System (ENDS): Focus on Heavy Metals Exposure and Cancer Risk.

A conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in Trypanosoma congolense (2024)
Journal Article
Silvester, E., Szoor, B., Ivens, A., Awuah-Mensah, G., Gadelha, C., Wickstead, B., & Matthews, K. R. (2024). A conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in Trypanosoma congolense. PLoS Pathogens, 20(2), Article e1011889. https://doi.org/10.1371/journal.ppat.1011889

Trypanosomatid parasites undergo developmental regulation to adapt to the different environments encountered during their life cycle. In Trypanosoma brucei, a genome wide selectional screen previously identified a regulator of the protein family ESAG... Read More about A conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in Trypanosoma congolense.

GABAergic and inflammatory changes in the frontal cortex following neonatal PCP plus isolation rearing, as a dual-hit neurodevelopmental model for schizophrenia (2024)
Journal Article
Cale, J. A., Chauhan, E. J., Cleaver, J. J., Fusciardi, A. R., McCann, S., Waters, H. C., …King, M. V. (2024). GABAergic and inflammatory changes in the frontal cortex following neonatal PCP plus isolation rearing, as a dual-hit neurodevelopmental model for schizophrenia. Molecular Neurobiology, https://doi.org/10.1007/s12035-024-03987-y

The pathogenesis of schizophrenia begins in early neurodevelopment and leads to excitatory-inhibitory imbalance. It is therefore essential that preclinical models used to understand disease, select drug targets and evaluate novel therapeutics encompa... Read More about GABAergic and inflammatory changes in the frontal cortex following neonatal PCP plus isolation rearing, as a dual-hit neurodevelopmental model for schizophrenia.

Development, characterization, and evaluation of a simple polymicrobial colony biofilm model for testing of antimicrobial wound dressings (2024)
Journal Article
Robertson, S. N., Romero, M., Fenn, S., Riedi, P. L. K., & Cámara, M. (2024). Development, characterization, and evaluation of a simple polymicrobial colony biofilm model for testing of antimicrobial wound dressings. Journal of Applied Microbiology, 135(3), Article lxae042. https://doi.org/10.1093/jambio/lxae042

Chronic wound infections are generally of polymicrobial nature with aerobic and anaerobic bacteria, as well as fungi frequently observed in them. Wound treatment involves a series of steps, including debridement of the wound, flushing, and often the... Read More about Development, characterization, and evaluation of a simple polymicrobial colony biofilm model for testing of antimicrobial wound dressings.

Spatially resolved molecular analysis of host response to medical device implantation using the 3D OrbiSIMS highlights a critical role for lipids (2024)
Journal Article
Suvannapruk, W., Fisher, L. E., Luckett, J. C., Edney, M. K., Kotowska, A. M., Kim, D. H., …Alexander, M. R. (2024). Spatially resolved molecular analysis of host response to medical device implantation using the 3D OrbiSIMS highlights a critical role for lipids. Advanced Science, 11(15), Article 2306000. https://doi.org/10.1002/advs.202306000

A key goal for implanted medical devices is that they do not elicit a detrimental immune response. Macrophages play critical roles in the modulation of the host immune response and are the cells responsible for persistent inflammatory reactions to im... Read More about Spatially resolved molecular analysis of host response to medical device implantation using the 3D OrbiSIMS highlights a critical role for lipids.

Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response (2024)
Journal Article
Jackson, H. K., Long, H. M., Yam‐Puc, J. C., Palmulli, R., Haigh, T. A., Gerber, P. P., …Edgar, J. R. (2024). Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response. Journal of Extracellular Vesicles, 13(2), Article e12412. https://doi.org/10.1002/jev2.12412

The COVID-19 pandemic highlighted the clear risk that zoonotic viruses pose to global health and economies. The scientific community responded by developing several efficacious vaccines which were expedited by the global need for vaccines. The emerge... Read More about Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response.

Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing (2024)
Journal Article
Salim, B., Nakao, R., Chatanga, E., Marcuzzi, O., Eissawi, M. A., Almathen, F., …Giovambattista, G. (2024). Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing. BMC Genomics, 25(1), Article 160. https://doi.org/10.1186/s12864-024-10053-3

Introduction The Ovar-DRB1 gene, a crucial element of the Major Histocompatibility Complex (MHC) Class II region, initiates adaptive immunity by presenting antigens to T-cells. Genetic diversity in sheep, particularly in MHC Class II genes like Ovar... Read More about Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing.

Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake (2024)
Journal Article
Ham, S., Mukaida, S., Sato, M., Keov, P., Bengtsson, T., Furness, S., …Hutchinson, D. S. (2024). Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake. Pharmacology Research and Perspectives, 12(1), Article e1176. https://doi.org/10.1002/prp2.1176

Truncation of the C‐terminal tail of the β2‐AR, transfection of βARKct or over‐expression of a kinase‐dead GRK mutant reduces isoprenaline‐stimulated glucose uptake, indicating that GRK is important for this response. We explored whether phosphorylat... Read More about Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake.

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches (2024)
Journal Article
Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., …Anderson, J. D. (2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles, 13(2), Article e12404. https://doi.org/10.1002/jev2.12404

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated bro... Read More about Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.

The evolution of the duckweed ionome mirrors losses in structural complexity (2024)
Journal Article
Smith, K. E., Zhou, M., Flis, P., Jones, D. H., Bishopp, A., & Yant, L. (2024). The evolution of the duckweed ionome mirrors losses in structural complexity. Annals of Botany, 133(7), 997-1006. https://doi.org/10.1093/aob/mcae012

• Background and Aims The duckweeds (Lemnaceae) consist of 36 species exhibiting impressive phenotypic variation, including the progressive evolutionary loss of a fundamental plant organ, the root. Loss of roots and reduction of vascular tissues in r... Read More about The evolution of the duckweed ionome mirrors losses in structural complexity.

Ciprofloxacin poly(β-amino ester) conjugates enhance antibiofilm activity and slow the development of resistance (2024)
Journal Article
Kasza, K., Richards, B., Jones, S., Romero, M., Robertson, S. N., Hardie, K. R., …Alexander, C. (2024). Ciprofloxacin poly(β-amino ester) conjugates enhance antibiofilm activity and slow the development of resistance. ACS Applied Materials and Interfaces, 16(5), 5412-5425. https://doi.org/10.1021/acsami.3c14357

To tackle the emerging antibiotic resistance crisis, novel antimicrobial approaches are urgently needed. Bacterial biofilms are a particular concern in this context as they are responsible for over 80% of bacterial infections and are inherently more... Read More about Ciprofloxacin poly(β-amino ester) conjugates enhance antibiofilm activity and slow the development of resistance.

Whole-genome resource sequences of 57 indigenous Ethiopian goats (2024)
Journal Article
Belay, S., Belay, G., Nigussie, H., Jian-Lin, H., Tijjani, A., Ahbara, A. M., …Mwacharo, J. M. (2024). Whole-genome resource sequences of 57 indigenous Ethiopian goats. Scientific Data, 11(1), Article 139. https://doi.org/10.1038/s41597-024-02973-2

Domestic goats are distributed worldwide, with approximately 35% of the one billion world goat population occurring in Africa. Ethiopia has 52.5 million goats, ~99.9% of which are considered indigenous landraces deriving from animals introduced to th... Read More about Whole-genome resource sequences of 57 indigenous Ethiopian goats.