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Purification of a chymotrypsin-like enzyme present on adult Schistosoma mansoni worms from infected mice and its characterization as a host carboxylesterase (2016)
Journal Article
Igetei, J. E., Liddell, S., El-Faham, M., & Doenhoff, M. J. (2016). Purification of a chymotrypsin-like enzyme present on adult Schistosoma mansoni worms from infected mice and its characterization as a host carboxylesterase. Parasitology, 143(5), 646-657. https://doi.org/10.1017/S0031182016000184

A serine protease-like enzyme found in detergent extracts of Schistosoma mansoni adult worms perfused from infected mice has been purified from mouse blood and further characterized. The enzyme is approximately 85 kDa and hydrolyses N-acetyl-DL-pheny... Read More about Purification of a chymotrypsin-like enzyme present on adult Schistosoma mansoni worms from infected mice and its characterization as a host carboxylesterase.

Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog (2016)
Journal Article
Davison, A., McDowell, G. S., Holden, J. M., Johnson, H. F., Koutsovoulos, G. D., Liu, M. M., …Blaxter, M. L. (2016). Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog. Current Biology, 26(5), 654-660. https://doi.org/10.1016/j.cub.2015.12.071

While components of the pathway that establishes left-right asymmetry have been identified in diverse animals, from vertebrates to flies, it is striking that the genes involved in the first symmetry-breaking step remain wholly unknown in the most obv... Read More about Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog.

The role of kinetic context in apparent biased agonism at GPCRs (2016)
Journal Article
Javitch, J. A., Klein Herenbrink, C., Sykes, D. A., Donthamsetti, P., Canals, M., Coudrat, T., …Lane, J. R. (2016). The role of kinetic context in apparent biased agonism at GPCRs. Nature Communications, 7, Article 10842. https://doi.org/10.1038/ncomms10842

Biased agonism describes the ability of ligands to stabilize different conformations of a GPCR linked to distinct functional outcomes and offers the prospect of designing pathway-specific drugs that avoid on-target side effects. This mechanism is usu... Read More about The role of kinetic context in apparent biased agonism at GPCRs.

The prognostic significance of STAT3 in invasive breast cancer: analysis of protein and mRNA expressions in large cohorts (2016)
Journal Article
Aleskandarany, M. A., Agarwal, D., Negm, O. H., Ball, G., Elmouna, A., Ashankyty, I., …Rakha, E. A. (2016). The prognostic significance of STAT3 in invasive breast cancer: analysis of protein and mRNA expressions in large cohorts. Breast Cancer Research and Treatment, 156(1), 9-20. https://doi.org/10.1007/s10549-016-3709-z

Signal transducer and activator of transcription (STAT) transcription factors family are involved in diverse cellular biological functions. Reports regarding the prognostic impact of STAT3 expression in breast cancer (BC) are variable whether being a... Read More about The prognostic significance of STAT3 in invasive breast cancer: analysis of protein and mRNA expressions in large cohorts.

Biogeographic distribution and habitat association of Ammonia genetic variants around the coastline of Great Britain (2016)
Journal Article
Saad, S., & Wade, C. (2016). Biogeographic distribution and habitat association of Ammonia genetic variants around the coastline of Great Britain. Marine Micropaleontology, 124, 54-62. https://doi.org/10.1016/j.marmicro.2016.01.004

High morphological variation and the lack of clearly defined morphological criteria for identification have led to difficulties in the identification of species in the foraminiferal genus Ammonia. It is often difficult to decide if morphological vari... Read More about Biogeographic distribution and habitat association of Ammonia genetic variants around the coastline of Great Britain.

Glycosylated notch and cancer (2016)
Journal Article
Pakkiriswami, S., Couto, A., Nagarajan, U., & Georgiou, M. (2016). Glycosylated notch and cancer. Frontiers in Oncology, 6(37), https://doi.org/10.3389/fonc.2016.00037

Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch an... Read More about Glycosylated notch and cancer.

Stepwise evolution of Elk-1 in early deuterostomes (2016)
Journal Article
Saxton, J., Ferjentsik, Z., Ducker, C., & Shaw, P. E. (in press). Stepwise evolution of Elk-1 in early deuterostomes. FEBS Journal, 283(6), https://doi.org/10.1111/febs.13607

Metazoans have multiple ETS paralogues with overlapping or indiscriminate biological functions. Elk- 1, one of three mammalian Ternary Complex Factors (TCFs), is a well-conserved, ETS domain-containing transcriptional regulator of mitogen-responsive... Read More about Stepwise evolution of Elk-1 in early deuterostomes.

Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors (2016)
Journal Article
Shang, Y., Yeatman, H., Provasi, D., Alt, A., Christopoulos, A., Canals, M., & Filizola, M. (2016). Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors. ACS Chemical Biology, 11(5), 1220-1229. https://doi.org/10.1021/acschembio.5b00712

Available crystal structures of opioid receptors provide a high-resolution picture of ligand binding at the primary ("orthosteric") site, that is, the site targeted by endogenous ligands. Recently, positive allosteric modulators of opioid receptors h... Read More about Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors.

The causal role of breakfast in energy balance and health: a randomized controlled trial in obese adults (2016)
Journal Article
Chowdhury, E. A., Richardson, J. D., Holman, G. D., Tsintzas, K., Thompson, D., & Betts, J. A. (2016). The causal role of breakfast in energy balance and health: a randomized controlled trial in obese adults. American Journal of Clinical Nutrition, 103(3), https://doi.org/10.3945/ajcn.115.122044

Background: The causal nature of associations between breakfast and health remain unclear in obese individuals. Objective: We sought to conduct a randomized controlled trial to examine causal links between breakfast habits and components of energy b... Read More about The causal role of breakfast in energy balance and health: a randomized controlled trial in obese adults.

Identification of gene modules associated with low temperatures response in Bambara groundnut by network-based analysis (2016)
Journal Article
Bonthala, V. S., Mayes, S., Moreton, J., Blythe, M. J., Wright, V., May, S., …Twycross, J. (2016). Identification of gene modules associated with low temperatures response in Bambara groundnut by network-based analysis. PLoS ONE, 11(2), Article e0148771. https://doi.org/10.1371/journal.pone.0148771

Bambara groundnut (Vigna subterranea (L.) Verdc.) is an African legume and is a promising underutilized crop with good seed nutritional values. Low temperature stress in a number of African countries at night, such as Botswana, can effect the growth... Read More about Identification of gene modules associated with low temperatures response in Bambara groundnut by network-based analysis.

Comparison and optimization of ten phage encoded serine integrases for genome engineering in Saccharomyces cerevisiae (2016)
Journal Article
Xu, Z., & Brown, W. (2016). Comparison and optimization of ten phage encoded serine integrases for genome engineering in Saccharomyces cerevisiae. BMC Biotechnology, 16, Article 13. https://doi.org/10.1186/s12896-016-0241-5

Background: Phage-encoded serine integrases, such as ?C31 integrase, are widely used for genome engineering but have not been optimized for use in Saccharomyces cerevisiae although this organism is a widely used organism in biotechnology. Results:... Read More about Comparison and optimization of ten phage encoded serine integrases for genome engineering in Saccharomyces cerevisiae.

Capturing the diversity of the human gut microbiota through culture-enriched molecular profiling (2016)
Journal Article
Lau, J. T., Whelan, F. J., Herath, I., Lee, C. H., Collins, S. M., Bercik, P., & Surette, M. G. (2016). Capturing the diversity of the human gut microbiota through culture-enriched molecular profiling. Genome Medicine, 8(1), Article 72. https://doi.org/10.1186/s13073-016-0327-7

Background The human gut microbiota has been implicated in most aspects of health and disease; however, most of the bacteria in this community are considered unculturable, so studies have relied on molecular-based methods. These methods generally... Read More about Capturing the diversity of the human gut microbiota through culture-enriched molecular profiling.

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12 (2016)
Journal Article
Jackson, V. E., Ntalla, I., Sayers, I., Morris, R., Whincup, P., Casas, J., …Wain, L. V. (in press). Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. Thorax, 71(6), https://doi.org/10.1136/thoraxjnl-2015-207876

Background Several regions of the genome have shown to be associated with COPD in genome-wide association studies of common variants. Objective To determine rare and potentially functional single nucleotide polymorphisms (SNPs) associated... Read More about Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.

Fruit gardens enhance mammal diversity and biomass in a Southeast Asian rainforest (2016)
Journal Article
Moore, J. H., Sittimongkol, S., Campos-Arceiz, A., Sumpah, T., & Eichhorn, M. P. (2016). Fruit gardens enhance mammal diversity and biomass in a Southeast Asian rainforest. Biological Conservation, 194, https://doi.org/10.1016/j.biocon.2015.12.015

Protected areas are frequently inhabited by people and conservation must be integrated with traditional management systems. Cultivation of fruit gardens is a low-impact agroforestry technique which alters the structure and composition of forest stand... Read More about Fruit gardens enhance mammal diversity and biomass in a Southeast Asian rainforest.

Long-term exposure to irinotecan reduces cell migration in glioma cells. (2016)
Journal Article
Al-Ghafari, A. B., Punjaruk, W., Storer, L., Carrier, D., Hussein, D., Coyle, B., & Kerr, I. D. (2016). Long-term exposure to irinotecan reduces cell migration in glioma cells. Journal of Neuro-Oncology, 127(3), 455-462. https://doi.org/10.1007/s11060-016-2058-4

In spite of considerable research into the therapies for glioblastoma multiforme this tumour type remains very difficult to treat. As well as having a tendency to be inherently resistant to chemotherapy, glioblastoma multiforme also displays local in... Read More about Long-term exposure to irinotecan reduces cell migration in glioma cells..

Asymmetric competition causes multimodal size distributions in spatially structured populations (2016)
Journal Article
Velázquez, J., Allen, R. B., Coomes, D. A., & Eichhorn, M. P. (2016). Asymmetric competition causes multimodal size distributions in spatially structured populations. Proceedings of the Royal Society B: Biological Sciences, 283(1823), 20152404. https://doi.org/10.1098/rspb.2015.2404

Plant sizes within populations often exhibit multimodal distributions, even when all individuals are the same age and have experienced identical conditions. To establish the causes of this, we created an individual-based model simulating the growth o... Read More about Asymmetric competition causes multimodal size distributions in spatially structured populations.

PqsBC, a condensing enzyme in the biosynthesis of the Pseudomonas aeruginosa quinolone signal: crystal structure, inhibition, and reaction mechanism (2016)
Journal Article
Drees, S. L., Li, C., Prasetya, F., Saleem, M., Dreveny, I., Williams, P., …Fetzner, S. (2016). PqsBC, a condensing enzyme in the biosynthesis of the Pseudomonas aeruginosa quinolone signal: crystal structure, inhibition, and reaction mechanism. Journal of Biological Chemistry, 291(13), https://doi.org/10.1074/jbc.M115.708453

Pseudomonas aeruginosa produces a number of alkylquinolone-type secondary metabolites best known for their antimicrobial effects and involvement in cell-cell communication. In the alkylquinolone biosynthetic pathway, the β-ketoacyl-(acyl carrier prot... Read More about PqsBC, a condensing enzyme in the biosynthesis of the Pseudomonas aeruginosa quinolone signal: crystal structure, inhibition, and reaction mechanism.

The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology and Influences Locomotor Activity in Drosophila Larvae (2016)
Journal Article
Ziegler, A. B., Augustin, H., Clark, N. L., Berthelot-Grosjean, M., Simonnet, M. M., Steinert, J. R., …Grosjean, Y. (2016). The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology and Influences Locomotor Activity in Drosophila Larvae. Scientific Reports, 6(1), Article 19692. https://doi.org/10.1038/srep19692

Changes in synaptic physiology underlie neuronal network plasticity and behavioral phenomena, which are adjusted during development. The Drosophila larval glutamatergic neuromuscular junction (NMJ) represents a powerful synaptic model to investigate... Read More about The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology and Influences Locomotor Activity in Drosophila Larvae.