All Outputs (561)

Role of VGF-derived peptides in the control of food intake, body weight and reproduction (2008)
Journal Article
Jethwa, P. H., & Ebling, F. J. P. (2008). Role of VGF-derived peptides in the control of food intake, body weight and reproduction. Neuroendocrinology, 88(2), 80-87. https://doi.org/10.1159/000127319

VGF is a 68-kDa polypeptide synthesized in neuronal and neuroendocrine cells. It is cleaved into a number of smaller peptides which are stored in dense core vesicles and are likely to be secreted products. The VGF gene is expressed abundantly in the... Read More about Role of VGF-derived peptides in the control of food intake, body weight and reproduction.

Insulin-like factor 3 levels in amniotic fluid of human male fetuses (2008)
Journal Article
Anand-Ivell, R., Ivell, R., Driscoll, D., & Manson, J. (2008). Insulin-like factor 3 levels in amniotic fluid of human male fetuses. Human Reproduction, 23(5), 1180-1186. https://doi.org/10.1093/humrep/den038

BACKGROUND: Rodent studies suggest that the peptide hormone insulin-like factor 3 (Insl3) made by the fetal testis is responsible for the first transabdominal phase of testicular descent, and may be affected by xenobiotics to disrupt male reproductiv... Read More about Insulin-like factor 3 levels in amniotic fluid of human male fetuses.

Effects of dietary polyphenols on gene expression in human vascular endothelial cells (2008)
Journal Article
Nicholson, S. K., Tucker, G. A., & Brameld, J. M. (2008). Effects of dietary polyphenols on gene expression in human vascular endothelial cells. Proceedings of the Nutrition Society, 67(1), 42-47. https://doi.org/10.1017/S0029665108006009

Previous studies have shown that consumption of fruit and vegetables plays a role in preventing the onset of CVD. These beneficial effects have been linked to the presence of polyphenolic compounds in plant-derived foods and their antioxidant capacit... Read More about Effects of dietary polyphenols on gene expression in human vascular endothelial cells.

Panel discussion [of paper: Thyroid disrupting chemicals: mechanisms and mixtures] (2008)
Journal Article
Anand-Ivell, R., Crofton, K., Ivell, R., Köhrle, J., & Kortenkamp, A. (2008). Panel discussion [of paper: Thyroid disrupting chemicals: mechanisms and mixtures]. International Journal of Andrology, 31(2), 222-223. https://doi.org/10.1111/j.1365-2605.2007.00857.x

This is a panel discussion (pages 222-223) of Kevin M. Crofton's paper Thyroid disrupting chemicals: mechanisms and mixtures. Summary of main paper: Environmental contaminants are known to act as thyroid disrupting chemicals (TDCs). Broadly def... Read More about Panel discussion [of paper: Thyroid disrupting chemicals: mechanisms and mixtures].

Diverse signalling mechanisms used by relaxin in natural cells and tissues: The evolution of a "neohormone" (2007)
Book Chapter
Ivell, R., Heng, K., & Anand-Ivell, R. (2007). Diverse signalling mechanisms used by relaxin in natural cells and tissues: The evolution of a "neohormone". In A. I. Agoulnik (Ed.), Relaxin and Related Peptides (26-33). Springer Verlag. https://doi.org/10.1007/978-0-387-74672-2_3

The small peptide hormone relaxin is a member of a rapidly evolving family of hormones and growth factors, whose mode of action appears to be particularly adapted to purely mammalian physiology. It is representative of a new category of hormones, ref... Read More about Diverse signalling mechanisms used by relaxin in natural cells and tissues: The evolution of a "neohormone".

Extraction and characterization of oil bodies from soy beans: A natural source of pre-emulsified soybean oil (2007)
Journal Article
Iwanaga, D., Gray, D. A., Fisk, I. D., Decker, E. A., Weiss, J., & McClements, D. J. (2007). Extraction and characterization of oil bodies from soy beans: A natural source of pre-emulsified soybean oil. Journal of Agricultural and Food Chemistry, 55(21), 8711-8716. https://doi.org/10.1021/jf071008w

Soybeans contain oil bodies that are coated by a layer of oleosin proteins. In nature, this protein coating protects the oil bodies from environmental stresses and may be utilized by food manufacturers for the same purpose. In this study, oil bodies... Read More about Extraction and characterization of oil bodies from soy beans: A natural source of pre-emulsified soybean oil.

Effect of maternal undernutrition on ruminant carcass and meat quality (2007)
Journal Article
Zoe, D., Brameld, J., Scollan, N., & Buttery, P. (2007). Effect of maternal undernutrition on ruminant carcass and meat quality. Archives Animal Breeding, 50(SPEC. ISS.), 22-23

We have previously shown that, in sheep, the majority of muscle differentiation and fibre formation takes place around d85 of gestation, with myoblast proliferation occurring before this time (FAHEY et al., 2005a). In a second study (FAHEY et al., 20... Read More about Effect of maternal undernutrition on ruminant carcass and meat quality.

VGF-derived peptide, TLQP-21, regulates food intake and body weight in Siberian hamsters (2007)
Journal Article
Jethwa, P. H., Warner, A., Nilaweera, K. N., Brameld, J. M., Keyte, J. W., Carter, W. G., …Ebling, F. J. (2007). VGF-derived peptide, TLQP-21, regulates food intake and body weight in Siberian hamsters. Endocrinology, 148(8), 4044-4055. https://doi.org/10.1210/en.2007-0038

The Siberian hamster survives winter by decreasing food intake and catabolizing abdominal fat reserves, resulting in a sustained, profound loss of body weight. VGF gene expression is photoperiodically regulated in the hypothalamus with significantly... Read More about VGF-derived peptide, TLQP-21, regulates food intake and body weight in Siberian hamsters.

Fetal exposure to a maternal low-protein diet during mid-gestation results in muscle-specific effects on fibre type composition in young rats (2007)
Journal Article
Mallinson, J. E., Sculley, D. V., Craigon, J., Plant, R., Langley-Evans, S. C., & Brameld, J. M. (2007). Fetal exposure to a maternal low-protein diet during mid-gestation results in muscle-specific effects on fibre type composition in young rats. British Journal of Nutrition, 98(2), 292-299. https://doi.org/10.1017/S0007114507701678

This study assessed the impact of reduced dietary protein during specific periods of fetal life upon muscle fibre development in young rats. Pregnant rats were fed a control or low-protein (LP) diet at early (days 0-7 gestation, LPEarly), mid (days 8... Read More about Fetal exposure to a maternal low-protein diet during mid-gestation results in muscle-specific effects on fibre type composition in young rats.

Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction (2007)
Journal Article
Barrett, P., Ebling, F. J., Schuhler, S., Wilson, D., Ross, A. W., Warner, A., …Morgan, P. J. (2007). Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction. Endocrinology, 148(8), 3608-3617. https://doi.org/10.1210/en.2007-0316

Seasonal adaptations in physiology exhibited by many animals involve an interface between biological timing and specific neuroendocrine systems, but the molecular basis of this interface is unknown. In this study of Siberian hamsters, we show that th... Read More about Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction.

Sunflower-seed oil body emulsions: Rheology and stability assessment of a natural emulsion (2007)
Journal Article
White, D. A., Fisk, I. D., Mitchell, J. R., Wolf, B., Hill, S. E., & Gray, D. A. (2008). Sunflower-seed oil body emulsions: Rheology and stability assessment of a natural emulsion. Food Hydrocolloids, 22(7), 1224-1232. https://doi.org/10.1016/j.foodhyd.2007.07.004

The viscoelastic characteristics of a purified oil body cream (67.6±0.7% lipid, 5.4±0.7% protein and 25.2±0.1% moisture) recovered from sunflower seeds (Helianthus annuus L.) have been determined. Moreover, the effects of pH (2-7) and CaCl2 concentra... Read More about Sunflower-seed oil body emulsions: Rheology and stability assessment of a natural emulsion.

Effect of maternal dietary restriction during pregnancy on lamb carcass characteristics and muscle fiber composition (2007)
Journal Article
Daniel, Z. C., Brameld, J. M., Craigon, J., Scollan, N. D., & Buttery, P. J. (2007). Effect of maternal dietary restriction during pregnancy on lamb carcass characteristics and muscle fiber composition. Journal of Animal Science, 85(6), 1565-1576. https://doi.org/10.2527/jas.2006-743

Two experiments were conducted to determine whether the decreased proportion of fast muscle fibers seen previously in 2-wk-old lambs from ewes that were dietary restricted from d 30 to 70 of gestation are still evident in older lambs and what the con... Read More about Effect of maternal dietary restriction during pregnancy on lamb carcass characteristics and muscle fiber composition.

Relaxin signalling in THP-1 cells uses a novel phosphotyrosine-dependent pathway (2007)
Journal Article
Anand-Ivell, R., Heng, K., Bartsch, O., & Ivell, R. (2007). Relaxin signalling in THP-1 cells uses a novel phosphotyrosine-dependent pathway. Molecular and Cellular Endocrinology, 272(1-2), 1-13. https://doi.org/10.1016/j.mce.2007.04.001

The heterodimeric peptide hormone relaxin acts through the novel G-protein coupled receptor LGR7 to elicit the production of cAMP in the human monocyte cell line THP-1. The very small number of receptors on the cell surface, and the lack of response... Read More about Relaxin signalling in THP-1 cells uses a novel phosphotyrosine-dependent pathway.

Thyrotrophin-releasing hormone decreases feeding and increases body temperature, activity and oxygen consumption in Siberian hamsters (2007)
Journal Article
Schuhler, S., Warner, A., Finney, N., Bennett, G. W., Ebling, F. J., & Brameld, J. M. (2007). Thyrotrophin-releasing hormone decreases feeding and increases body temperature, activity and oxygen consumption in Siberian hamsters. Journal of Neuroendocrinology, 19(4), 239-249. https://doi.org/10.1111/j.1365-2826.2006.01524.x

Thyrotrophin-releasing hormone (TRH) is known to play an important role in the control of food intake and energy metabolism in addition to its actions on the pituitary-thyroid axis. We have previously shown that central administration of TRH decrease... Read More about Thyrotrophin-releasing hormone decreases feeding and increases body temperature, activity and oxygen consumption in Siberian hamsters.

Peptide YY (PYY) And Neuromedin U (NMU): Effects On Ingestive Behavior (2006)
Book Chapter
Small, C. J., Jethwa, P. H., & Bloom, S. R. (2006). Peptide YY (PYY) And Neuromedin U (NMU): Effects On Ingestive Behavior. In A. J. Kastin (Ed.), Handbook of Biologically Active Peptides (945-952). Academic Press. https://doi.org/10.1016/B978-012369442-3/50132-X

This chapter discusses the effects of Neuromedin U (NMU) and Peptide YY (PYY) on ingestive behavior and their potential as anti-obesity agents. Many peptides are synthesized and released from the gastrointestinal (GI) tract and the central nervous sy... Read More about Peptide YY (PYY) And Neuromedin U (NMU): Effects On Ingestive Behavior.

Neuromedin U (NMU): Brain Peptide (2006)
Book Chapter
Jethwa, P. H., Small, C. J., & Bloom, S. R. (2006). Neuromedin U (NMU): Brain Peptide. In A. J. Kastin (Ed.), Handbook of Biologically Active Peptides (745-751). Academic Press. https://doi.org/10.1016/B978-012369442-3/50106-9

Neuromedin U (NMU) is one of the most abundant neuropeptides and has been found in significant concentrations in both the gastrointestinal (GI) tract and the central nervous system (CNS). There are two molecular forms of NMU; an icosapentapeptide (NM... Read More about Neuromedin U (NMU): Brain Peptide.

Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats (2006)
Journal Article
Thompson, E. L., Murphy, K. G., Patterson, M., Bewick, G. A., Stamp, G. W., Curtis, A. E., …Bloom, S. R. (2006). Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats. AJP - Endocrinology and Metabolism, 291(5), https://doi.org/10.1152/ajpendo.00040.2006

The kisspeptins are KiSS-1 gene-derived peptides that signal through the G protein-coupled receptor-54 (GPR54) and have recently been shown to be critical regulators of reproduction. Acute intracerebroventricular or peripheral administration of kissp... Read More about Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats.

Peripheral INSL3 concentrations decline with age in a large population of Australian men (2006)
Journal Article
Anand-Ivell, R., Wohlgemuth, J., Haren, M. T., Hope, P. J., Hatzinikolas, G., Wittert, G., & Ivell, R. (2006). Peripheral INSL3 concentrations decline with age in a large population of Australian men. International Journal of Andrology, 29(6), 618-626. https://doi.org/10.1111/j.1365-2605.2006.00714.x

The novel peptide hormone insulin-like peptide 3 (INSL3) is a major secretory product of the Leydig cells of the testis, and in adult men is secreted into the blood, giving rise to circulating concentrations ranging from 0.5 to 2.5 ng/mL. We studied... Read More about Peripheral INSL3 concentrations decline with age in a large population of Australian men.

Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat (2006)
Journal Article
Jethwa, P. H., Smith, K. L., Small, C. J., Abbott, C. R., Darch, S. J., Murphy, K. G., …Bloom, S. R. (2006). Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat. Endocrinology, 147(6), 2886-2892. https://doi.org/10.1210/en.2005-0983

Intracerebroventricular (ICV) administration of the hypothalamic neuropeptide neuromedin U (NMU) or the adipostat hormone leptin increases plasma ACTH and corticosterone. The relationship between leptin and NMU in the regulation of the hypothalamo-pi... Read More about Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat.

Expression of the insulin-like peptide 3 (INSL3) hormone-receptor (LGR8) system in the testis (2006)
Journal Article
Anand-Ivell, R. J., Relan, V., Balvers, M., Coiffec-Dorval, I., Fritsch, M., Bathgate, R. A., & Ivell, R. (2006). Expression of the insulin-like peptide 3 (INSL3) hormone-receptor (LGR8) system in the testis. Biology of Reproduction, 74(5), 945-953. https://doi.org/10.1095/biolreprod.105.048165

The new peptide hormone insulin-like peptide 3 (INSL3) is a member of the insulin-relaxin family, yet, unlike insulin, it signals through a new G-protein coupled receptor, LGR8, distantly related to the receptors for LH and FSH. INSL3 is produced in... Read More about Expression of the insulin-like peptide 3 (INSL3) hormone-receptor (LGR8) system in the testis.