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Fetal exposure to a maternal low-protein diet during mid-gestation results in muscle-specific effects on fibre type composition in young rats

Mallinson, Joanne E.; Sculley, Dean V.; Craigon, Jim; Plant, Richard; Langley-Evans, Simon C.; Brameld, John M.

Authors

Joanne E. Mallinson

Dean V. Sculley

Jim Craigon

Richard Plant

Simon C. Langley-Evans

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JOHN BRAMELD JOHN.BRAMELD@NOTTINGHAM.AC.UK
Professor of Nutritional Biochemistry



Abstract

This study assessed the impact of reduced dietary protein during specific periods of fetal life upon muscle fibre development in young rats. Pregnant rats were fed a control or low-protein (LP) diet at early (days 0-7 gestation, LPEarly), mid (days 8-14, LPMid), late (days 15-22, LPLate) or throughout gestation (days 0-22, LPAll). The muscle fibre number and composition in soleus and gastrocnemius muscles of the offspring were studied at 4 weeks of age. In the soleus muscle, both the total number and density of fast fibres were reduced in LPMid females (P=004 for both, Diet × Sex × Fibre type interactions), while both the total number and density of glycolytic (non-oxidative) fibres were reduced in LPEarly, LPMid and LPLate (but not LPAll) offspring compared with controls (P

Citation

Mallinson, J. E., Sculley, D. V., Craigon, J., Plant, R., Langley-Evans, S. C., & Brameld, J. M. (2007). Fetal exposure to a maternal low-protein diet during mid-gestation results in muscle-specific effects on fibre type composition in young rats. British Journal of Nutrition, 98(2), 292-299. https://doi.org/10.1017/S0007114507701678

Journal Article Type Article
Acceptance Date Jan 29, 2006
Publication Date Aug 1, 2007
Deposit Date Feb 9, 2021
Journal British Journal of Nutrition
Print ISSN 0007-1145
Electronic ISSN 1475-2662
Publisher Cambridge University Press (CUP)
Peer Reviewed Peer Reviewed
Volume 98
Issue 2
Pages 292-299
DOI https://doi.org/10.1017/S0007114507701678
Public URL https://nottingham-repository.worktribe.com/output/3185883
Publisher URL https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/fetal-exposure-to-a-maternal-lowprotein-diet-during-midgestation-results-in-musclespecific-effects-on-fibre-type-composition-in-young-rats/2C0284EB58E89D2BFC481A3E59F9EF10