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Protease responsive nanoprobes with tethered fluorogenic peptidyl 3-arylcoumarin substrates (2008)
Journal Article
Welser, K., Grilj, J., Vauthey, E., Aylott, J. W., & Chan, W. C. (2009). Protease responsive nanoprobes with tethered fluorogenic peptidyl 3-arylcoumarin substrates. Chemical Communications, 671-673. https://doi.org/10.1039/b816637d

Protease responsive nanosensors were obtained by the attachment of unique green fluorescent bifunctional 3-arylcoumarin-derived fluorogenic substrates to poly(acrylamide-co-N-(3-aminopropyl)methacrylamide) nanoparticles, in which proteolysis results... Read More about Protease responsive nanoprobes with tethered fluorogenic peptidyl 3-arylcoumarin substrates.

A macroporous polymer-supported cyclic anhydride for efficient sequestration of amines (2008)
Journal Article
Sanna, M., White, P. D., & Chan, W. C. (2008). A macroporous polymer-supported cyclic anhydride for efficient sequestration of amines. Tetrahedron Letters, 49(42), 6160-6162. https://doi.org/10.1016/j.tetlet.2008.08.038

The efficient removal of primary and secondary amines from organic solutions using a macroporous polymer-supported anhydride is described. The sequestering of primary amines by the anhydride via polymer-bound amide formation is completed within 2-4 h... Read More about A macroporous polymer-supported cyclic anhydride for efficient sequestration of amines.

Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC (2008)
Journal Article
Jensen, R. O., Winzer, K., Clarke, S. R., Chan, W. C., & Williams, P. (2008). Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC. Journal of Molecular Biology, 381(2), 300-309. https://doi.org/10.1016/j.jmb.2008.06.018

Virulence in Staphylococcus aureus is regulated via agr-dependent quorum sensing in which an autoinducing peptide (AIP) activates AgrC, a histidine protein kinase. AIPs are usually thiolactones containing seven to nine amino acid residues in which th... Read More about Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC.

Targeting of polyamidoamine-DNA nanoparticles using the Staudinger ligation: Attachment of an RGD motif either before or after complexation (2008)
Journal Article
Parkhouse, S. M., Garnett, M. C., & Chan, W. C. (2008). Targeting of polyamidoamine-DNA nanoparticles using the Staudinger ligation: Attachment of an RGD motif either before or after complexation. Bioorganic and Medicinal Chemistry, 16(13), 6641-6650. https://doi.org/10.1016/j.bmc.2008.05.023

Two new methods for the modular synthesis of targeted gene delivery systems are reported. The PEGylated polyamidoamine DMEDA-PEG-DMEDA-(MBA-DMEDA)n+1-PEG-DMEDA 3 was sequentially modified to contain an integrin-binding peptide ligand via the Stauding... Read More about Targeting of polyamidoamine-DNA nanoparticles using the Staudinger ligation: Attachment of an RGD motif either before or after complexation.

Molecular mechanism of target recognition by subtilin, a class I lanthionine antibiotic (2008)
Journal Article
Parisot, J., Carey, S., Breukink, E., Chan, W. C., Narbad, A., & Bonev, B. (2008). Molecular mechanism of target recognition by subtilin, a class I lanthionine antibiotic. Antimicrobial Agents and Chemotherapy, 52(2), 612-618. https://doi.org/10.1128/AAC.00836-07

The increasing resistance of human pathogens to conventional antibiotics presents a growing threat to the chemotherapeutic management of infectious diseases. The lanthionine antibiotics, still unused as therapeutic agents, have recently attracted sig... Read More about Molecular mechanism of target recognition by subtilin, a class I lanthionine antibiotic.

Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels (2007)
Journal Article
Pardon, M. C., Sarmad, S., Rattray, I., Bates, T. E., Scullion, G. A., Marsden, C. A., …Kendall, D. A. (2007). Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30(7), 1099-1113. https://doi.org/10.1016/j.neurobiolaging.2007.10.002

Environmental factors (e.g. stress, exercise, enrichment) are thought to play a role in the development of Alzheimer's disease later in life. We investigated the influence of repeated novel cage exposure on the development of early Alzheimer's-like p... Read More about Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels.

Internally quenched peptides for the study of lysostaphin: An antimicrobial protease that kills Staphylococcus aureus (2006)
Journal Article
Warfield, R., Bardelang, P., Saunders, H., Chan, W. C., Penfold, C., James, R., & Thomas, N. R. (2006). Internally quenched peptides for the study of lysostaphin: An antimicrobial protease that kills Staphylococcus aureus. Organic and Biomolecular Chemistry, 4(19), 3626-3638. https://doi.org/10.1039/b607999g

Lysostaphin (EC. 3.4.24.75) is a protein secreted by Staphylococcus simulans biovar staphylolyticus and has been shown to be active against methicillin resistant S. aureus (MRSA). The design and synthesis of three internally quenched substrates for l... Read More about Internally quenched peptides for the study of lysostaphin: An antimicrobial protease that kills Staphylococcus aureus.

Antigenicity of chimeric and cyclic synthetic peptides based on nonstructural proteins of GBV-C/HGV (2005)
Journal Article
Pérez, T., Ercilla, G., Chan, W. C., & Haro, I. (2006). Antigenicity of chimeric and cyclic synthetic peptides based on nonstructural proteins of GBV-C/HGV. Journal of Peptide Science, 12(4), 267-278. https://doi.org/10.1002/psc.719

In this work, new putative epitopes located in nonstructural proteins of GBV-C/HGV were synthesized using solid-phase chemistry for their use in immunoassays. The antigens were obtained in linear, chimeric and cyclic forms with the main aim of improv... Read More about Antigenicity of chimeric and cyclic synthetic peptides based on nonstructural proteins of GBV-C/HGV.

Discovery of antagonist peptides against bacterial helicase-primase interaction in B. stearothermophilus by reverse yeast three-hybrid (2005)
Journal Article
Gardiner, L., Coyle, B. J., Chan, W. C., & Soultanas, P. (2005). Discovery of antagonist peptides against bacterial helicase-primase interaction in B. stearothermophilus by reverse yeast three-hybrid. Cell Chemistry Biology, 12(5), 595-604. https://doi.org/10.1016/j.chembiol.2005.04.007

Developing small-molecule antagonists against protein-protein interactions will provide powerful tools for mechanistic/functional studies and the discovery of new antibacterials. We have developed a reverse yeast three-hybrid approach that allows hig... Read More about Discovery of antagonist peptides against bacterial helicase-primase interaction in B. stearothermophilus by reverse yeast three-hybrid.

Modulation of pRb/E2F functions in the regulation of cell cycle and in cancer (2005)
Journal Article
Seville, L. L., Shah, N., Westwell, A. D., & Chan, W. C. (2005). Modulation of pRb/E2F functions in the regulation of cell cycle and in cancer. Current Cancer Drug Targets, 5(3), 159-170. https://doi.org/10.2174/1568009053765816

Cell proliferation is regulated by the cell cycle, and in order to divide the cell must enter a mitotic state. Prior to mitosis the cell is required to pass through a number of checkpoints, including the critical G1/S restriction point governed by th... Read More about Modulation of pRb/E2F functions in the regulation of cell cycle and in cancer.

A study to investigate the extent of delivery of an intervention in asthma, in a UK national community pharmacy chain, using mystery customers (2005)
Journal Article
Thornley, T., Gray, N., Anderson, C., & Eastham, S. (2006). A study to investigate the extent of delivery of an intervention in asthma, in a UK national community pharmacy chain, using mystery customers. Patient Education and Counseling, 60(2), 246-252. https://doi.org/10.1016/j.pec.2005.01.016

Objective: The objective of this study was to implement a brief intervention in asthma within a UK national pharmacy chain, and through the use of mystery customers, measure the extent of delivery of the intervention over a 4-month period. Methods: M... Read More about A study to investigate the extent of delivery of an intervention in asthma, in a UK national community pharmacy chain, using mystery customers.

The contribution of community pharmacy to improving the public’s health. Report 3, An overview of evidence-base from 1990-2002 and recommendations for action (2005)
Book
Armstrong, M., Lewis, R., Anderson, C., & Blenkinsopp, A. (2005). The contribution of community pharmacy to improving the public’s health. Report 3, An overview of evidence-base from 1990-2002 and recommendations for action. PharmacyHealthLink and the Royal Pharmaceutical Society of Great Britain

Community pharmacists have always played a significant role in promoting, maintaining and improving the public’s health. Based at the heart of communities, they gain a unique understanding of the health needs of the communities they serve through dai... Read More about The contribution of community pharmacy to improving the public’s health. Report 3, An overview of evidence-base from 1990-2002 and recommendations for action.