All Outputs (48)

Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge (2013)
Journal Article
Beattie, K. A., Luscombe, C., Williams, G., Munoz-Muriedas, J., Gavaghan, D. J., Cui, Y., & Mirams, G. R. (2013). Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge. Journal of Pharmacological and Toxicological Methods, 68(1), 88-96. https://doi.org/10.1016/j.vascn.2013.04.004

Introduction Drugs that prolong the QT interval on the electrocardiogram present a major safety concern for pharmaceutical companies and regulatory agencies. Despite a range of assays performed to assess compound effects on the QT interval, QT prolo... Read More about Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge.

Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment (2013)
Journal Article
Elkins, R. C., Davies, M. R., Brough, S. J., Gavaghan, D. J., Cui, Y., Abi-Gerges, N., & Mirams, G. R. (2013). Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment. Journal of Pharmacological and Toxicological Methods, 68(1), 112-122. https://doi.org/10.1016/j.vascn.2013.04.007

Introduction: Unwanted drug interactions with ionic currents in the heart can lead to an increased pro-arrhythmic risk to patients in the clinic. It is therefore a priority for safety pharmacology teams to detect block of cardiac ion channels, and ne... Read More about Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment.

Probabilistic inference of short-term synaptic plasticity in neocortical microcircuits (2013)
Journal Article
Costa, R. P., Sjöström, P. J., & van Rossum, M. C. (2013). Probabilistic inference of short-term synaptic plasticity in neocortical microcircuits. Frontiers in Computational Neuroscience, 7, https://doi.org/10.3389/fncom.2013.00075

Short-term synaptic plasticity is highly diverse across brain area, cortical layer, cell type, and developmental stage. Since short-term plasticity (STP) strongly shapes neural dynamics, this diversity suggests a specific and essential role in neural... Read More about Probabilistic inference of short-term synaptic plasticity in neocortical microcircuits.

hp-Version composite discontinuous Galerkin methods for elliptic problems on complicated domains (2013)
Journal Article
Antonietti, P. F., Giani, S., & Houston, P. (2013). hp-Version composite discontinuous Galerkin methods for elliptic problems on complicated domains. SIAM Journal on Scientific Computing, 35(3), Article A1417-A1439. https://doi.org/10.1137/120877246

In this paper we introduce the hp-version discontinuous Galerkin composite finite element method for the discretization of second-order elliptic partial differential equations. This class of methods allows for the approximation of problems posed on c... Read More about hp-Version composite discontinuous Galerkin methods for elliptic problems on complicated domains.

Subdeterminant approach for pseudo-orbit expansions of spectral determinants in quantum maps and quantum graphs (2013)
Journal Article
Waltner, D., Gnutzmann, S., Tanner, G., & Richter, K. (2013). Subdeterminant approach for pseudo-orbit expansions of spectral determinants in quantum maps and quantum graphs. Physical Review E, 87(5), https://doi.org/10.1103/PhysRevE.87.052919

We study implications of unitarity for pseudo-orbit expansions of the spectral determinants of quantum maps and quantum graphs. In particular, we advocate to group pseudo-orbits into sub-determinants. We show explicitly that the cancellation of long... Read More about Subdeterminant approach for pseudo-orbit expansions of spectral determinants in quantum maps and quantum graphs.

Berry phase quantum thermometer (2013)
Journal Article
Martin-Martinez, E., Dragan, A., Mann, R. B., & Fuentes, I. (2013). Berry phase quantum thermometer. New Journal of Physics, 15, Article 053036. https://doi.org/10.1088/1367-2630/15/5/053036

We show how the Berry phase can be used to construct a high-precision quantum thermometer. An important advantage of our scheme is that there is no need for the thermometer to acquire thermal equilibrium with the sample. This reduces measurement time... Read More about Berry phase quantum thermometer.

Separating invariants for arbitrary linear actions of the additive group (2013)
Journal Article
Dufresne, E., Elmer, J., & Sezer, M. (2014). Separating invariants for arbitrary linear actions of the additive group. manuscripta mathematica, 143(1-2), https://doi.org/10.1007/s00229-013-0625-y

We consider an arbitrary representation of the additive group Ga over a field of characteristic zero and give an explicit description of a finite separating set in the corresponding ring of invariants.

Genuine tripartite entanglement and nonlocality in Bose-Einstein condensates by collective atomic recoil (2013)
Journal Article
Piano, S., & Adesso, G. (2013). Genuine tripartite entanglement and nonlocality in Bose-Einstein condensates by collective atomic recoil. Entropy, 15(5), https://doi.org/10.3390/e15051875

We study a system represented by a Bose-Einstein condensate interacting with a cavity field in presence of a strong off-resonant pumping laser. This system can be described by a three-mode Gaussian state, where two are the atomic modes corresponding... Read More about Genuine tripartite entanglement and nonlocality in Bose-Einstein condensates by collective atomic recoil.

Seven new champion linear codes (2013)
Journal Article
Brown, G., & Kasprzyk, A. M. (2013). Seven new champion linear codes. LMS Journal of Computation and Mathematics, 16, https://doi.org/10.1112/S1461157013000041

We exhibit seven linear codes exceeding the current best known minimum distance d for their dimension k and block length n. Each code is defined over F?, and their invariants [n,k,d] are given by [49,13,27], [49,14,26], [49,16,24], [49,17,23], [49,19... Read More about Seven new champion linear codes.

Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs (2013)
Journal Article
Hirt, B. V., Wattis, J. A., & Preston, S. P. (2014). Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs. Journal of Mathematical Biology, 68(6), 1521-1552. https://doi.org/10.1007/s00285-013-0678-2

Telomeres are guanine-rich sequences at the end of chromosomes which shorten during each replication event and trigger cell cycle arrest and/or controlled death (apoptosis) when reaching a threshold length. The enzyme telomerase replenishes the ends... Read More about Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs.

Is a persistent global bias necessary for the establishment of planar cell polarity? (2013)
Journal Article
Fischer, S., Houston, P., Monk, N. A., & Owen, M. R. (2013). Is a persistent global bias necessary for the establishment of planar cell polarity?. PLoS ONE, 8(4), 1-12. https://doi.org/10.1371/journal.pone.0060064

Planar cell polarity (PCP) — the coordinated polarisation of a whole field of cells within the plane of a tissue — relies on the interaction of three modules: a global module that couples individual cellular polarity to the tissue axis, a local modul... Read More about Is a persistent global bias necessary for the establishment of planar cell polarity?.

Spreading dynamics on spatially constrained complex brain networks (2013)
Journal Article
O'Dea, R. D., Crofts, J. J., & Kaiser, M. (2013). Spreading dynamics on spatially constrained complex brain networks. Interface, 10(81), https://doi.org/10.1098/%E2%80%8Brsif.2013.0016

The study of dynamical systems defined on complex networks provides a natural framework with which to investigate myriad features of neural dynamics, and has been widely undertaken. Typically, however, networks employed in theoretical studies bear... Read More about Spreading dynamics on spatially constrained complex brain networks.

Travelling waves in a neural field model with refractoriness (2013)
Journal Article
Meijer, H. G., & Coombes, S. (2014). Travelling waves in a neural field model with refractoriness. Journal of Mathematical Biology, 68(5), 1249-1268. https://doi.org/10.1007/s00285-013-0670-x

At one level of abstraction neural tissue can be regarded as a medium for turning local synaptic activity into output signals that propagate over large distances via axons to generate further synaptic activity that can cause reverberant activity in n... Read More about Travelling waves in a neural field model with refractoriness.

Small polygons and toric codes (2013)
Journal Article
Brown, G., & Kasprzyk, A. M. (2013). Small polygons and toric codes. Journal of Symbolic Computation, 51, https://doi.org/10.1016/j.jsc.2012.07.001

We describe two different approaches to making systematic classifications of plane lattice polygons, and recover the toric codes they generate, over small fields, where these match or exceed the best known minimum distance. This includes a [36,19,12]... Read More about Small polygons and toric codes.

A biophysical model of endocannabinoid-mediated short term depression in hippocampal inhibition (2013)
Journal Article
Zachariou, M., Alexander, S. P., Coombes, S., & Christodoulou, C. (2013). A biophysical model of endocannabinoid-mediated short term depression in hippocampal inhibition. PLoS ONE, 8(3), Article e58296. https://doi.org/10.1371/journal.pone.0058926

Memories are believed to be represented in the synaptic pathways of vastly interconnected networks of neurons. The plasticity of synapses, that is, their strengthening and weakening depending on neuronal activity, is believed to be the basis of lea... Read More about A biophysical model of endocannabinoid-mediated short term depression in hippocampal inhibition.

Chaste: An Open Source C++ Library for Computational Physiology and Biology (2013)
Journal Article
Mirams, G. R., Arthurs, C. J., Bernabeu, M. O., Bordas, R., Cooper, J., Corrias, A., …Gavaghan, D. J. (2013). Chaste: An Open Source C++ Library for Computational Physiology and Biology. PLoS Computational Biology, 9(3), e1002970. https://doi.org/10.1371/journal.pcbi.1002970

Chaste - Cancer, Heart And Soft Tissue Environment - is an open source C++ library for the computational simulation of mathematical models developed for physiology and biology. Code development has been driven by two initial applications: cardiac ele... Read More about Chaste: An Open Source C++ Library for Computational Physiology and Biology.

Behaviour of the extended Volterra lattice (2013)
Journal Article
Pickering, A., Gordoa, P. R., & Wattis, J. A. (2013). Behaviour of the extended Volterra lattice. Communications in Nonlinear Science and Numerical Simulation, 19(3), https://doi.org/10.1016/j.cnsns.2013.07.009

We investigate the behaviour of solutions of the recently proposed extended Volterra lattice. A variety of methods are used to determine the effects of the new terms on small amplitude equations, and, following approximation of the partial differenti... Read More about Behaviour of the extended Volterra lattice.

mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study (2013)
Journal Article
Walmsley, J., Rodriguez, J. F., Mirams, G. R., Burrage, K., Efimov, I. R., & Rodriguez, B. (2013). mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study. PLoS ONE, 8(2), https://doi.org/10.1371/journal.pone.0056359

Differences in mRNA expression levels have been observed in failing versus non-failing human hearts for several membrane channel proteins and accessory subunits. These differences may play a causal role in electrophysiological changes observed in hum... Read More about mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study.

Dead-time effects on the voltage spectrum of a PWM inverter (2013)
Journal Article
Moore, D. C., Odavic, M., & Cox, S. M. (2014). Dead-time effects on the voltage spectrum of a PWM inverter. IMA Journal of Applied Mathematics, 79(6), https://doi.org/10.1093/imamat/hxt006

An inverter converts a direct-current power supply to an alternating-current power supply. This con- version is achieved by switching the output between the inputs at high frequency. The resulting output voltage may be described by a high-frequency t... Read More about Dead-time effects on the voltage spectrum of a PWM inverter.

Influence of slow oscillation on hippocampal activity and ripples through cortico-hippocampal synaptic interactions, analyzed by a cortical-CA3-CA1 network model (2013)
Journal Article
Taxidis, J., Mizuseki, K., Mason, R., & Owen, M. R. (2013). Influence of slow oscillation on hippocampal activity and ripples through cortico-hippocampal synaptic interactions, analyzed by a cortical-CA3-CA1 network model. Frontiers in Computational Neuroscience, 7(Februa), Article 19. https://doi.org/10.3389/fncom.2013.00003

Hippocampal sharp wave-ripple complexes (SWRs) involve the synchronous discharge of thousands of cells throughout the CA3-CA1-subiculum-entorhinal cortex axis. Their strong transient output affects cortical targets, rendering SWRs a possible means f... Read More about Influence of slow oscillation on hippocampal activity and ripples through cortico-hippocampal synaptic interactions, analyzed by a cortical-CA3-CA1 network model.