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Is a persistent global bias necessary for the establishment of planar cell polarity?

Fischer, Sabine; Houston, Paul; Monk, Nick A.M.; Owen, Markus R.

Authors

Sabine Fischer Sabine.Fischer@physikalischebiologie.de

Paul Houston Paul.Houston@nottingham.ac.uk

Nick A.M. Monk n.monk@sheffield.ac.uk

Markus R. Owen Markus.Owen@nottingham.ac.uk

Abstract

Planar cell polarity (PCP) — the coordinated polarisation of a whole field of cells within the plane of a tissue — relies on the interaction of three modules: a global module that couples individual cellular polarity to the tissue axis, a local module that aligns the axis of polarisation of neighbouring cells, and a readout module that directs the correct outgrowth of PCP-regulated structures such as hairs and bristles. While much is known about the molecular components that are required for PCP, the functional details of—and interactions between—the modules remain unclear. In this work, we perform a mathematical and computational analysis of two previously proposed computational models of the local module (Amonlirdviman et al., Science, 307, 2005; Le Garrec et al., Dev. Dyn., 235, 2006). Both models can reproduce wild-type and mutant phenotypes of PCP observed in the Drosophila wing under the assumption that a tissue-wide polarity cue from the global module persists throughout the development of PCP. We demonstrate that both models can also generate tissue-level PCP when provided with only a transient initial polarity cue. However, in these models such transient cues are not sufficient to ensure robustness of the resulting cellular polarisation.

Journal Article Type Article
Publication Date Apr 8, 2013
Journal PLoS ONE
Electronic ISSN 1932-6203
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 8
Issue 4
Article Number e60064
Pages 1-12
Institution Citation Fischer, S., Houston, P., Monk, N. A., & Owen, M. R. (2013). Is a persistent global bias necessary for the establishment of planar cell polarity?. PLoS ONE, 8(4), 1-12. doi:10.1371/journal.pone.0060064
DOI https://doi.org/10.1371/journal.pone.0060064
Keywords Planar cell polarity, cellular polarisation, embryo development
Publisher URL http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060064
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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