All Outputs (165)

Spectroscopic analysis of 1-butyl-2,3-dimethylimidazolium ionic liquids: cation-anion interactions (2017)
Journal Article

In this study, four 1-butyl-2,3-dimethylimidazolium ionic liquids are analysed by X-ray photoelectron spectroscopy, together with three 1-butyl-3-methylimidazolium ionic liquids. A reliable fitting model for the carbon 1s region of 1-butyl-2,3-dimeth... Read More about Spectroscopic analysis of 1-butyl-2,3-dimethylimidazolium ionic liquids: cation-anion interactions.

Controlling the release of indomethacin from glass solutions layered with a rate controlling membrane using fluid-bed processing. Part 1: Surface and cross-sectional chemical analysis (2017)
Journal Article

Fluid bed coating has been shown to be a suitable manufacturing technique to formulate poorly soluble drugs in glass solutions. Layering inert carriers with a drug–polymer mixture enables these beads to be immediately filled into capsules, thus avoid... Read More about Controlling the release of indomethacin from glass solutions layered with a rate controlling membrane using fluid-bed processing. Part 1: Surface and cross-sectional chemical analysis.

Redox-active organic-inorganic hybrid polyoxometalate micelles (2017)
Journal Article

A redox-active hybrid organic-inorganic polyoxometalate surfactant showed solvent-dependent self-assembly to form nano-scale architectures. The supramolecular assemblies exhibited contrasting electronic structure and redox activity to their molecular... Read More about Redox-active organic-inorganic hybrid polyoxometalate micelles.

Stop-frame filming and discovery of reactions at the single-molecule level by transmission electron microscopy (2017)
Journal Article

We report an approach – named chemTEM – to follow chemical transformations at the single-molecule level with the electron beam of a transmission electron microscope (TEM) applied as both a tuneable source of energy and a sub-Angstrom imaging probe. D... Read More about Stop-frame filming and discovery of reactions at the single-molecule level by transmission electron microscopy.

1H CSA parameters by ultrafast MAS NMR: measurement and applications to structure refinement (2017)
Journal Article

A 1H anisotropic-isotropic chemical shift correlation experiment which employs symmetry-based recoupling sequences to reintroduce the chemical shift anisotropy in ?1 and ultrafast MAS to resolve 1H sites in ?2 is described. This experiment is used to... Read More about 1H CSA parameters by ultrafast MAS NMR: measurement and applications to structure refinement.

Low-cost and sustainable organic thermoelectrics based on low-dimensional molecular metals (2017)
Journal Article

More than 70 % of the primary energy consumed world-wide is wasted, mostly as heat below 100 °C[1]. Thermoelectric generators may convert a substantial amount of this energy into electrical power but high production costs and scarcity of efficient th... Read More about Low-cost and sustainable organic thermoelectrics based on low-dimensional molecular metals.

Enzyme engineering: A synthetic biology approach for more effective library generation and automated high-throughput screening (2017)
Journal Article

The Golden Gate strategy entails the use of type IIS restriction enzymes, which cut outside of their recognition sequence. It enables unrestricted design of unique DNA fragments that can be readily and seamlessly recombined. Successfully employed in... Read More about Enzyme engineering: A synthetic biology approach for more effective library generation and automated high-throughput screening.

Probing the origins of vibrational mode specificity in intramolecular dynamics through picosecond time-resolved photoelectron imaging studies (2017)
Journal Article

We have studied the intramolecular dynamics induced by selective photoexcitation of two near-isoenergetic vibrational states in S1 p-fluorotoluene using picosecond time-resolved photoelectron imaging. We find that similar dynamics ensue following the... Read More about Probing the origins of vibrational mode specificity in intramolecular dynamics through picosecond time-resolved photoelectron imaging studies.

Interpolated energy densities, correlation indicators and lower bounds from approximations to the strong coupling limit of DFT (2017)
Journal Article

We investigate the construction of approximated exchange-correlation functionals by interpolating locally along the adiabatic connection between the weak- and the strong-coupling regimes, focussing on the effect of using approximate functionals for t... Read More about Interpolated energy densities, correlation indicators and lower bounds from approximations to the strong coupling limit of DFT.

Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor (2017)
Journal Article

Despite decades of research in the epidermal growth factor receptor (EGFR) signalling field, and many targeted anti-cancer drugs that have been tested clinically, the success rate for these agents in the clinic is low, particularly in terms of the im... Read More about Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor.

The inverse-trans-influence in tetravalent lanthanide and actinide bis(carbene) complexes (2017)
Journal Article

© The Author(s) 2017. Across the periodic table the trans-influence operates, whereby tightly bonded ligands selectively lengthen mutually trans metal-ligand bonds. Conversely, in high oxidation state actinide complexes the inverse-trans-influence op... Read More about The inverse-trans-influence in tetravalent lanthanide and actinide bis(carbene) complexes.

Total Synthesis of the Post‐translationally Modified Polyazole Peptide Antibiotic Goadsporin (2017)
Journal Article

The structurally unique polyazole antibiotic goadsporin contains six heteroaromatic oxazole and thiazole rings integrated into a linear array of amino acids that also contains two dehydroalanine residues. An efficient total synthesis of goadsporin is... Read More about Total Synthesis of the Post‐translationally Modified Polyazole Peptide Antibiotic Goadsporin.

Electrochemical Optimization of Gold Nanoparticles for Efficient Electron Transfer—Implication for Highly Sensitive Biosensing (2017)
Journal Article

Nanoscale engineering of hybrid magnetite–carbon nanofibre materials for magnetic resonance imaging contrast agents (2017)
Journal Article

Magnetic nanomaterials show significant promise as contrast agents for magnetic resonance imaging (MRI). We have developed a new highly efficient one-step procedure for the synthesis of magnetically- functionalised hollow carbon nanofibres, where (i)... Read More about Nanoscale engineering of hybrid magnetite–carbon nanofibre materials for magnetic resonance imaging contrast agents.

Terminal uranium(V/VI) nitride activation of carbon dioxide and carbon disulfide: factors governing diverse and well-defined cleavage and redox reactions (2017)
Journal Article

The reactivity of terminal uranium(V/VI) nitrides with CE2 (E=O, S) is presented. Well-defined C=E cleavage followed by zero-, one-, and two-electron redox events is observed. The uranium(V) nitride [U(TrenTIPS)(N)][K(B15C5)2] (1, TrenTIPS=N(CH2CH2NS... Read More about Terminal uranium(V/VI) nitride activation of carbon dioxide and carbon disulfide: factors governing diverse and well-defined cleavage and redox reactions.

Using titanium complexes to defeat cancer: the view from the shoulders of titans (2017)
Journal Article

When the first titanium complex with anticancer activity was identified in the 1970s, it was attractive, based on the presence of the dichloride unit in TiCl2Cp2 (Cp = ?-C5H5)2, to assume its mode of biological action was closely aligned with cisplat... Read More about Using titanium complexes to defeat cancer: the view from the shoulders of titans.

Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells (2017)
Journal Article

Polymer micelles have emerged as promising carriers for controlled release applications, however, several limitations of micelle-based drug delivery have also been reported. To address these issues, we have synthesized a functional biodegradable and... Read More about Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells.

Identifying and understanding strong vibronic interaction effects observed in the asymmetry of chiral molecule photoelectron angular distributions (2017)
Journal Article

Electron-ion coincidence imaging is used to study chiral asymmetry in the angular distribution of electrons emitted from randomly-oriented enantiomers of two molecules, methyloxirane and trifluoromethyloxirane, upon ionization by circularly polarized... Read More about Identifying and understanding strong vibronic interaction effects observed in the asymmetry of chiral molecule photoelectron angular distributions.

Theoretical study of Si+(2PJ)-RG complexes and transport of Si+(2PJ) in RG (RG = He – Ar) (2017)
Journal Article

We calculate accurate interatomic potentials for the interaction of a singly-charged silicon cation with a rare gas atom of helium, neon or argon. We employ the RCCSD(T) method, and basis sets of quadruple- and quintuple-? quality; each point is coun... Read More about Theoretical study of Si+(2PJ)-RG complexes and transport of Si+(2PJ) in RG (RG = He – Ar).

Palladium-catalyzed enantioselective C-H activation of aliphatic amines using chiral anionic BINOL-phosphoric acid ligands (2017)
Journal Article

© 2017 American Chemical Society. The design of an enantioselective Pd(II)-catalyzed C-H amination reaction is described. The use of a chiral BINOL phosphoric acid ligand enables the conversion of readily available amines into synthetically valuable... Read More about Palladium-catalyzed enantioselective C-H activation of aliphatic amines using chiral anionic BINOL-phosphoric acid ligands.