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Using titanium complexes to defeat cancer: the view from the shoulders of titans

Cini, Melchoir; Bradshaw, Tracey D.; Woodward, Simon

Authors

Melchoir Cini

Tracey D. Bradshaw

Simon Woodward simon.woodward@nottingham.ac.uk



Abstract

When the first titanium complex with anticancer activity was identified in the 1970s, it was attractive, based on the presence of the dichloride unit in TiCl2Cp2 (Cp = η-C5H5)2, to assume its mode of biological action was closely aligned with cisplatin [cis-PtCl2(NH3)2]. Over the intervening 40 years however a far more complicated picture has arisen indicating multiple cellular mechanisms of cellular action can be triggered by titanium anti-cancer agents. This tutorial review aims to unpick the historical data and provide new researchers, without an explicit cancer biology background, a contemporary interpretation of both older and newer literature and to review the best techniques for attaining the identities of the biologically active titanium species and how these interact with the cancer cellular machinery.

Journal Article Type Article
Journal Chemical Society Reviews
Print ISSN 0306-0012
Electronic ISSN 1460-4744
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
APA6 Citation Cini, M., Bradshaw, T. D., & Woodward, S. (in press). Using titanium complexes to defeat cancer: the view from the shoulders of titans. Chemical Society Reviews, doi:10.1039/C6CS00860G
DOI https://doi.org/10.1039/C6CS00860G
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2017/CS/C6CS00860G#!divAbstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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