Adam P. Smalley
Palladium-catalyzed enantioselective C-H activation of aliphatic amines using chiral anionic BINOL-phosphoric acid ligands
Smalley, Adam P.; Cuthbertson, James D.; Gaunt, Matthew J.
Authors
James D. Cuthbertson
Matthew J. Gaunt
Abstract
© 2017 American Chemical Society. The design of an enantioselective Pd(II)-catalyzed C-H amination reaction is described. The use of a chiral BINOL phosphoric acid ligand enables the conversion of readily available amines into synthetically valuable aziridines in high enantiomeric ratios. The aziridines can be derivatized to afford a range of chiral amine building blocks incorporating motifs readily encountered in pharmaceutically relevant molecules.
Citation
Smalley, A. P., Cuthbertson, J. D., & Gaunt, M. J. (2017). Palladium-catalyzed enantioselective C-H activation of aliphatic amines using chiral anionic BINOL-phosphoric acid ligands. Journal of the American Chemical Society, 139(4), 1412-1415. https://doi.org/10.1021/jacs.6b12234
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 19, 2016 |
Online Publication Date | Jan 9, 2017 |
Publication Date | Feb 1, 2017 |
Deposit Date | Dec 4, 2018 |
Publicly Available Date | Dec 6, 2018 |
Journal | Journal of the American Chemical Society |
Print ISSN | 0002-7863 |
Electronic ISSN | 1520-5126 |
Publisher | American Chemical Society |
Peer Reviewed | Peer Reviewed |
Volume | 139 |
Issue | 4 |
Pages | 1412-1415 |
DOI | https://doi.org/10.1021/jacs.6b12234 |
Public URL | https://nottingham-repository.worktribe.com/output/1358552 |
Publisher URL | https://pubs.acs.org/doi/10.1021/jacs.6b12234 |
Contract Date | Dec 6, 2018 |
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