Penetration and uptake of Nanoparticles in 3D tumour spheroids

Tchoryk, Aleksandra; Taresco, Vincenzo; Argent, Richard; Ashford, Marianne B.; Gellert, Paul; Stolnik, Snow; Grabowska, Anna M.; Garnett, Martin C.

doi:10.1021/acs.bioconjchem.9b00136

All Outputs (8)

Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide (2019)
Journal Article

© 2020 The Royal Society of Chemistry. Combinations of conventional chemotherapeutics with unconventional anticancer agents such as reactive oxygen and nitrogen species may offer treatment benefits for cancer therapies. Here we report a novel polymer... Read More about Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide.

A simple and efficient method for polymer coating of iron oxide nanoparticles (2019)
Journal Article

Iron oxide nanoparticles (IONP) have many possible uses including as MRI contrast agents, for drug delivery and cell labelling, but need to be stabilised and to be rendered biocompatible through appropriate coatings. Many current coatings are subopti... Read More about A simple and efficient method for polymer coating of iron oxide nanoparticles.

Enhanced performance of Candida rugosa lipase immobilized onto alkyl chain modified-magnetic nanocomposites (2019)
Journal Article

Lipase-immobilized nanomaterials with high activity and stable reusability would have a great impact in different fields. However, developing such materials has proven to be challenging. Herein, polymer (pAcDED)-coated magnetic nanoparticles (MNPs) d... Read More about Enhanced performance of Candida rugosa lipase immobilized onto alkyl chain modified-magnetic nanocomposites.

Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update (2019)
Journal Article

The enzymatically synthesized poly (glycerol adipate) (PGA) has demonstrated all the desirable key properties required from a performing biomaterial to be considered a versatile “polymeric-tool” in the broad ﬁeld of drug delivery. The step-growth po... Read More about Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update.

Role of Self‐Assembly Conditions and Amphiphilic Balance on Nanoparticle Formation of PEG‐PDLLA Copolymers in Aqueous Environments (2019)
Journal Article

The production of well-defined and reproducible poly-meric nanoparticles (NPs), in terms of size and stability in biological environments, is undoubtedly a fundamental challenge in the formulation of novel and more effective nanomedicines. The adopti... Read More about Role of Self‐Assembly Conditions and Amphiphilic Balance on Nanoparticle Formation of PEG‐PDLLA Copolymers in Aqueous Environments.

Starch/Poly (Glycerol-Adipate) Nanocomposite Film as Novel Biocompatible Materials (2019)
Journal Article

Starch is one of the most abundant polysaccharides on the earth and it is the most important source of energy intake for humans. Thermoplastic starch (TPS) is also widely used for new bio-based materials. The blending of starch with other molecules m... Read More about Starch/Poly (Glycerol-Adipate) Nanocomposite Film as Novel Biocompatible Materials.

Amphiphilic tri- and tetra-block co-polymers combining versatile functionality with facile assembly into cytocompatible nanoparticles (2019)
Journal Article

In order for synthetic polymers to find widespread practical application as biomaterials, their syntheses must be easy to perform, utilising freely available building blocks, and should generate products which have no adverse effects on cells or tiss... Read More about Amphiphilic tri- and tetra-block co-polymers combining versatile functionality with facile assembly into cytocompatible nanoparticles.

Penetration and uptake of Nanoparticles in 3D tumour spheroids (2019)
Journal Article

Animal models are effective for assessing tumour localisation of nanosystems, but difficult to use for studying penetration beyond the vasculature. Here, we have used well-characterised HCT116 colorectal cancer spheroids to study the effect of nanopa... Read More about Penetration and uptake of Nanoparticles in 3D tumour spheroids.