Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update

Swainson, Sadie M.E.; Styliari, Ioanna D.; Taresco, Vincenzo; Garnett, Martin C.

Abstract

The enzymatically synthesized poly (glycerol adipate) (PGA) has demonstrated all the desirable key properties required from a performing biomaterial to be considered a versatile “polymeric-tool” in the broad field of drug delivery. The step-growth polymerization pathway catalyzed by lipase generates a highly functionalizable platform while avoiding tedious steps of protection and deprotection. Synthesis requires only minor purification steps and uses cheap and readily available reagents. The final polymeric material is biodegradable, biocompatible and intrinsically amphiphilic, with a good propensity to self-assemble into nanoparticles (NPs). The free hydroxylgrouplendsitselftoavarietyofchemicalderivatizationsviasimplereactionpathwayswhich alteritsphysico-chemicalpropertieswithapossibilitytogenerateanendlessnumberofpossibleactive macromolecules. The present work aims to summarize the available literature about PGA synthesis, architecture alterations, chemical modifications and its application in drug and gene delivery as a versatile carrier. Following on from this, the evolution of the concept of enzymatically-degradable PGA-drug conjugation has been explored, reporting recent examples in the literature.

Citation

Swainson, S. M., Styliari, I. D., Taresco, V., & Garnett, M. C. (2019). Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update. Polymers, 11(10), 1561. https://doi.org/10.3390/polym11101561

• Journal Article Type: Article
• Acceptance Date: Sep 20, 2019
• Online Publication Date: Sep 25, 2019
• Publication Date: 2019-10
• Deposit Date: Sep 30, 2019
• Publicly Available Date: Oct 1, 2019
• Journal: Polymers
• Electronic ISSN: 2073-4360
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 10
• Pages: 1561
• DOI: https://doi.org/10.3390/polym11101561
• Public URL: https://nottingham-repository.worktribe.com/output/2722168
• Publisher URL: https://www.mdpi.com/2073-4360/11/10/1561
• Contract Date: Oct 1, 2019