All Outputs (39)

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth (2016)
Journal Article

We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20 ppm in feed) or Reporcin (recombi... Read More about Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth.

The impact of growth promoters on muscle growth and the potential consequences for meat quality (2016)
Journal Article

To meet the demands of increased global meat consumption, animal production systems will have to become more efficient, or at least maintain the current efficiency utilizing feed ingredients that are not also used for human consumption. Use of growth... Read More about The impact of growth promoters on muscle growth and the potential consequences for meat quality.

Improving efficiency in meat production (2016)
Journal Article

Selective breeding and improved nutritional management over the past 20–30 years has resulted in dramatic improvements in growth efficiency for pigs and poultry, particularly lean tissue growth. However, this has been achieved using high-quality feed... Read More about Improving efficiency in meat production.

The active form of vitamin D, Calcitriol, induces vasodilation in the rat aorta (2015)
Journal Article

Transcriptome analysis of mRNA and miRNA in skeletal muscle indicates an important network for differential Residual Feed Intake in pigs (2015)
Journal Article

Feed efficiency (FE) can be measured by feed conversion ratio (FCR) or residual feed intake (RFI). In this study, we measured the FE related phenotypes of 236 castrated purebred Yorkshire boars, and selected 10 extreme individuals with high and low R... Read More about Transcriptome analysis of mRNA and miRNA in skeletal muscle indicates an important network for differential Residual Feed Intake in pigs.

Expression of the myosin heavy chain IIB gene in porcine skeletal muscle: the role of the CArG-box promoter response element (2014)
Journal Article

Due to its similarity to humans, the pig is increasingly being considered as a good animal model for studying a range of human diseases. Despite their physiological similarities, differential expression of the myosin heavy chain (MyHC) IIB gene (MYH4... Read More about Expression of the myosin heavy chain IIB gene in porcine skeletal muscle: the role of the CArG-box promoter response element.

Differential effects of short-term ? agonist and growth hormone treatments on expression of myosin heavy chain IIB and associated metabolic genes in sheep muscle (2014)
Journal Article

Growth hormone (GH) and ? agonists increase muscle mass, but the mechanisms for this response are unclear and the magnitude of response is thought to vary with age of animal. To investigate the mechanisms driving the muscle response to these agents,... Read More about Differential effects of short-term ? agonist and growth hormone treatments on expression of myosin heavy chain IIB and associated metabolic genes in sheep muscle.

Dose-dependent effects of vitamin D on transdifferentiation of skeletal muscle cells to adipose cells (2013)
Journal Article

Fat infiltration within muscle is one of a number of features of vitamin D deficiency, which leads to a decline in muscle functionality. The origin of this fat is unclear, but one possibility is that it forms from myogenic precursor cells present in... Read More about Dose-dependent effects of vitamin D on transdifferentiation of skeletal muscle cells to adipose cells.

Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis (2011)
Journal Article

The regulation of muscle fibre transitions has mainly been studied in vivo using conventional histological or immunohistochemical techniques. In order to investigate the molecular regulation of myosin heavy chain (MyHC) isoform expression in cell cul... Read More about Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis.

Use of the Affymetrix human GeneChip array and genomic DNA hybridisation probe selection to study ovine transcriptomes (2011)
Journal Article

Affymetrix GeneChip microarrays are a powerful tool to study global gene expression profiles and have been used on many species. However, no sheep-specific Affymetrix GeneChip is currently available and the bovine array is fairly limited in its cover... Read More about Use of the Affymetrix human GeneChip array and genomic DNA hybridisation probe selection to study ovine transcriptomes.

Calpastatin is associated with lymphovascular invasion in breast cancer (2011)
Journal Article

Metastasis of breast cancer is a major contributor to mortality. Histological assessment of vascular invasion (VI) provides important prognostic information and demonstrates that VI occurs predominantly via lymphatics in breast cancer. We sought to e... Read More about Calpastatin is associated with lymphovascular invasion in breast cancer.

The calpain system and cancer (2011)
Journal Article

The calpains are a conserved family of cysteine proteinases that catalyse the controlled proteolysis of many specific substrates. Calpain activity is implicated in several fundamental physiological processes, including cytoskeletal remodelling, cellu... Read More about The calpain system and cancer.

Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols (2010)
Journal Article

Stearoyl CoA desaturase (SCD) is responsible for converting SFA into MUFA and plays an important role in regulating the fatty acid composition of tissues. Although the number of SCD isoforms differs among species, SCD-1 is the predominant isoform exp... Read More about Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols.

Examination of myosin heavy chain isoform expression in ovine skeletal muscles (2009)
Journal Article

The contractile and associated metabolic characteristics of muscles are determined by their myosin heavy chain (MHC) isoform expression. In large mammals, the level of MHCIIB expression, which is associated with fast glycolytic-type muscle fibers, ha... Read More about Examination of myosin heavy chain isoform expression in ovine skeletal muscles.

The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb (2005)
Journal Article

There is a need to improve the lean tissue content of ruminant animals destined for meat production. Muscle fiber number is set during fetal development. The effect of undernutrition of pregnant ewes on subsequent muscle fiber characteristics of thei... Read More about The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb.

The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb (2005)
Journal Article

There is a need to improve the lean tissue content of ruminant animals destined for meat production. Muscle fiber number is set during fetal development. The effect of undernutrition of pregnant ewes on subsequent muscle fiber characteristics of thei... Read More about The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb.

Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus (2005)
Journal Article

The number of muscle fibers within a muscle has been found to be of high importance for the growth potential of an animal, and this number is set during fetal development. The objective of this study was to identify the ontogeny of muscle cell differ... Read More about Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus.

Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus (2005)
Journal Article

The number of muscle fibers within a muscle has been found to be of high importance for the growth potential of an animal, and this number is set during fetal development. The objective of this study was to identify the ontogeny of muscle cell differ... Read More about Ontogeny of factors associated with proliferation and differentiation of muscle in the ovine fetus.

Expression of calpastatin isoforms in muscle and functionality of multiple calpastatin promoters (2004)
Journal Article

Calpastatin is the specific endogenous inhibitor of calpain proteinase that is encoded by a single gene. Transient transfection assays in both a non-fusing skeletal muscle and non-muscle cell-line demonstrated that the putative porcine calpastatin pr... Read More about Expression of calpastatin isoforms in muscle and functionality of multiple calpastatin promoters.