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All Outputs (33)

Developing and evaluating threshold-based algorithms to detect drinking behavior in dairy cows using reticulorumen temperature (2019)
Journal Article
Vázquez-Diosdado, J., Miguel-Pacheco, G., Plant, B., Dottorini, T., Green, M., & Kaler, J. (2019). Developing and evaluating threshold-based algorithms to detect drinking behavior in dairy cows using reticulorumen temperature. Journal of Dairy Science, 102(11), 10471-10482. https://doi.org/10.3168/jds.2019-16442

© 2019 American Dairy Science Association In this study, we assessed for the first time the use of a reticuloruminal temperature bolus and a thresholding method to detect drinking events and investigated different factors that can affect drinking beh... Read More about Developing and evaluating threshold-based algorithms to detect drinking behavior in dairy cows using reticulorumen temperature.

Evolution of gene expression levels in the male reproductive organs of Anopheles mosquitoes (2019)
Journal Article
Izquierdo, A., Fahrenberger, M., Persampieri, T., Benedict, M. Q., Giles, T., Catteruccia, F., …Dottorini, T. (2019). Evolution of gene expression levels in the male reproductive organs of Anopheles mosquitoes. Life Science Alliance, 2(1), Article e00191. https://doi.org/10.26508/lsa.201800191

Modifications in gene expression determine many of the phenotypic differentiations between closely related species. This is particularly evident in reproductive tissues, where evolution of genes is more rapid, facilitating the appearance of distinct... Read More about Evolution of gene expression levels in the male reproductive organs of Anopheles mosquitoes.

Discrimination of contagious and environmental strains of Streptococcus uberis in dairy herds by means of mass spectrometry and machine-learning (2018)
Journal Article
Esener, N., Green, M. J., Emes, R. D., Jowett, B., Davies, P. L., Bradley, A. J., & Dottorini, T. (2018). Discrimination of contagious and environmental strains of Streptococcus uberis in dairy herds by means of mass spectrometry and machine-learning. Scientific Reports, 8(1), Article 17517. https://doi.org/10.1038/s41598-018-35867-6

Streptococcus uberis is one of the most common pathogens of clinical mastitis in the dairy industry. Knowledge of pathogen transmission route is essential for the selection of the most suitable intervention. Here we show that spectral profiles acquir... Read More about Discrimination of contagious and environmental strains of Streptococcus uberis in dairy herds by means of mass spectrometry and machine-learning.

Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis (2018)
Journal Article
Probert, C., Dottorini, T., Speakman, A., Hunt, S., Nafee, T., Fazeli, A., …James, V. (2019). Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis. Oncogene, 38(10), 1751-1763. https://doi.org/10.1038/s41388-018-0540-5

© 2018, The Author(s). The role of extracellular vesicles (EVs) as vehicles for cell-to-cell communication between a tumour and its environment is a relatively new concept. The hypothesis that EVs may be critical in co-opting tissues by tumours to ge... Read More about Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis.

Acute Toxoplasma gondii infection in cats induced tissue-specific transcriptional response dominated by immune signatures (2018)
Journal Article
Cong, W., Dottorini, T., Khan, F., Emes, R. D., Zhang, F., Zhou, C., …Zhu, X. (2018). Acute Toxoplasma gondii infection in cats induced tissue-specific transcriptional response dominated by immune signatures. Frontiers in Immunology, 9, Article 2403. https://doi.org/10.3389/fimmu.2018.02403

RNA-sequencing was used to detect transcriptional changes in six tissues of cats, seven days after T. gondii infection. A total of 737 genes were differentially expressed (DEGs), of which 410 were up-regulated and 327 were down-regulated. The liver e... Read More about Acute Toxoplasma gondii infection in cats induced tissue-specific transcriptional response dominated by immune signatures.

Feature selection and comparison of machine learning algorithms in classification of grazing and rumination behaviour in sheep (2018)
Journal Article
Mansbridge, N., Mitsch, J., Bollard, N., Ellis, K., Miguel-Pacheco, G. G., Dottorini, T., & Kaler, J. (2018). Feature selection and comparison of machine learning algorithms in classification of grazing and rumination behaviour in sheep. Sensors, 18(10), Article 3532. https://doi.org/10.3390/s18103532

Grazing and ruminating are the most important behaviours for ruminants, as they spend most of their daily time budget performing these. Continuous surveillance of eating behaviour is an important means for monitoring ruminant health, productivity and... Read More about Feature selection and comparison of machine learning algorithms in classification of grazing and rumination behaviour in sheep.

A recombinant Fasciola gigantica 14-3-3 epsilon protein (rFg14-3-3e) modulates various functions of goat peripheral blood mononuclear cells (2018)
Journal Article
Tian, A., Lu, M., Calderón-Mantilla, G., Petsalaki, E., Dottorini, T., Tian, X., …Zhu, X. (2018). A recombinant Fasciola gigantica 14-3-3 epsilon protein (rFg14-3-3e) modulates various functions of goat peripheral blood mononuclear cells. Parasites and Vectors, 11(1), https://doi.org/10.1186/s13071-018-2745-4

Background The molecular structure of Fasciola gigantica 14-3-3 protein has been characterized. However, the involvement of this protein in parasite pathogenesis remains elusive and its effect on the functions of innate immune cells is unknown. We... Read More about A recombinant Fasciola gigantica 14-3-3 epsilon protein (rFg14-3-3e) modulates various functions of goat peripheral blood mononuclear cells.

Evaluation of sampling frequency, window size and sensor position for classification of sheep behaviour (2018)
Journal Article
Walton, E., Casey, C., Mitsch, J., Vázquez-Diosdado, J. A., Yan, J., Dottorini, T., …Kaler, J. (2018). Evaluation of sampling frequency, window size and sensor position for classification of sheep behaviour. Royal Society Open Science, 5(2), https://doi.org/10.1098/rsos.171442

Automated behavioural classification and identification through sensors has the potential to improve health and welfare of the animals. Position of a sensor, sampling frequency and window size of segmented signal data has a major impact on classifica... Read More about Evaluation of sampling frequency, window size and sensor position for classification of sheep behaviour.

VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria (2015)
Journal Article
Canavese, M., Dottorini, T., & Crisanti, A. (2015). VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria. Pathogens and Global Health, 109(6), doi:10.1179/2047773215Y.0000000018

Malaria infection induces, alongside endothelial damage and obstruction hypoxia, a potent inflammatory response similar to that observed in other systemic diseases caused by bacteria and viruses. Accordingly, it is increasingly recognised that cerebr... Read More about VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria.

Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes (2015)
Journal Article
Neafsey, D. E., Waterhouse, R. M., Abai, M. R., Aganezov, S. S., Alekseyev, M. A., Allen, J. E., …Besansky, N. J. (2015). Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes. 00 Journal not listed, 347(6217), Article 1258522. https://doi.org/10.1126/science.1258522

Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vecto... Read More about Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.

CluGene: A Bioinformatics Framework for the Identification of Co-Localized, Co-Expressed and Co-Regulated Genes Aimed at the Investigation of Transcriptional Regulatory Networks from High-Throughput Expression Data (2013)
Journal Article
Dottorini, T., Palladino, P., Senin, N., Persampieri, T., Spaccapelo, R., & Crisanti, A. (2013). CluGene: A Bioinformatics Framework for the Identification of Co-Localized, Co-Expressed and Co-Regulated Genes Aimed at the Investigation of Transcriptional Regulatory Networks from High-Throughput Expression Data. PLoS ONE, 8(6), doi:10.1371/journal.pone.0066196

The full understanding of the mechanisms underlying transcriptional regulatory networks requires unravelling of complex causal relationships. Genome high-throughput technologies produce a huge amount of information pertaining gene expression and regu... Read More about CluGene: A Bioinformatics Framework for the Identification of Co-Localized, Co-Expressed and Co-Regulated Genes Aimed at the Investigation of Transcriptional Regulatory Networks from High-Throughput Expression Data.

Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female (2012)
Journal Article
Dottorini, T., Persampieri, T., Palladino, P., Baker, D. A., Spaccapelo, R., Senin, N., & Crisanti, A. (2013). Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female. FASEB Journal, 27(1), 86-97. doi:10.1096/fj.12-219444

In Drosophila, the accessory gland proteins (Acps) secreted from the male accessory glands (MAGs) and transferred along with sperm into the female reproductive tract have been implicated in triggering postmating behavioral changes, including refracto... Read More about Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female.