All Outputs (111)

Exploring structure and function of sensory cortex with 7 T MRI (2017)
Journal Article

In this paper, we present an overview of 7 Tesla magnetic resonance imaging (MRI) studies of the detailed function and anatomy of sensory areas of the human brain. We discuss the motivation for the studies, with particular emphasis on increasing the... Read More about Exploring structure and function of sensory cortex with 7 T MRI.

Endotoxemia in peritoneal dialysis patients: a pilot study to examine the role of intestinal perfusion and congestion (2017)
Journal Article

Endotoxemia is common in advanced chronic kidney disease and is particularly severe in those receiving dialysis. In hemodialysis patients, translocation from the bowel occurs as a consequence of recurrent circulatory stress leading to a reduction in... Read More about Endotoxemia in peritoneal dialysis patients: a pilot study to examine the role of intestinal perfusion and congestion.

Intradialytic Cardiac Magnetic Resonance Imaging to Assess Cardiovascular Responses in a Short-Term Trial of Hemodiafiltration and Hemodialysis (2016)
Journal Article

Hemodynamic stress during hemodialysis (HD) results in recurrent segmental ischemic injury (myocardial stunning) that drives cumulative cardiac damage. We performed a fully comprehensive study of the cardiovascular effect of dialysis sessions using i... Read More about Intradialytic Cardiac Magnetic Resonance Imaging to Assess Cardiovascular Responses in a Short-Term Trial of Hemodiafiltration and Hemodialysis.

Imaging the kidney using magnetic resonance techniques: structure to function (2016)
Journal Article

Purpose of review Magnetic resonance imaging (MRI) offers the possibility to non-invasively assess both the structure and function of the kidney in a single MR scan session. This review summarises recent advancements in functional renal MRI techniqu... Read More about Imaging the kidney using magnetic resonance techniques: structure to function.

Field strength dependence of grey matter R2* on venous oxygenation (2016)
Journal Article

The relationship between venous blood oxygenation and change in transverse relaxation rate (?R2 *) plays a key role in calibrated BOLD fMRI. This relationship, defined by the parameter ?, has previously been determined using theoretical simulations a... Read More about Field strength dependence of grey matter R2* on venous oxygenation.

Prior Consumption of a Fat Meal in Healthy Adults Modulates the Brain's Response to Fat (2016)
Journal Article

Background: Consumption of fat is regulated by reward and homeostatic pathways, but no studies have examined the role of the intake of a high fat meal (HFM) on subsequent brain activation to oral stimuli. Objective: We evaluated how prior consumptio... Read More about Prior Consumption of a Fat Meal in Healthy Adults Modulates the Brain's Response to Fat.

Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging (2016)
Journal Article

Background & Aims Hepatic venous pressure gradient (HVPG) measurement is currently the only validated technique to accurately evaluate changes in portal pressure. In this study, we evaluate the use of non-contrast quantitative magnetic resonance i... Read More about Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging.

Anticipation of thermal pain in diverticular disease (2016)
Journal Article

Background The relative importance of peripheral nerve injury or differences in central pain processing in painful diverticular disease (DD) is unclear. Functional MRI has demonstrated changes in the anticipation of pain in irritable bowel syndrom... Read More about Anticipation of thermal pain in diverticular disease.

Thermal taster status: evidence of cross-modal integration (2016)
Journal Article

Thermal taster status refers to the finding that, in some individuals, thermal stimulation of the tongue elicits a phantom taste. Little is known regarding the mechanism for this, it is hypothesised to be a result of cross-wiring between gustatory an... Read More about Thermal taster status: evidence of cross-modal integration.

Global signal modulation of single-trial fMRI response variability: effect on positive vs negative BOLD response relationship (2016)
Journal Article

In functional magnetic resonance imaging (fMRI), the relationship between positive BOLD responses (PBRs) and negative BOLD responses (NBRs) to stimulation is potentially informative about the balance of excitatory and inhibitory brain responses in se... Read More about Global signal modulation of single-trial fMRI response variability: effect on positive vs negative BOLD response relationship.

Voxel-based, brain-wide association study of aberrant functional connectivity in schizophrenia implicates thalamocortical circuitry (2015)
Journal Article

BACKGROUND: Wernicke’s concept of ‘sejunction’ or aberrant associations among specialized brain regions is one of the earliest hypotheses attempting to explain the myriad of symptoms in psychotic disorders. Unbiased data mining of all possible brain-... Read More about Voxel-based, brain-wide association study of aberrant functional connectivity in schizophrenia implicates thalamocortical circuitry.

Functional connectivity in MRI is driven by spontaneous BOLD events (2015)
Journal Article

A study of T1 relaxation time as a measure of liver fibrosis and the influence of confounding histological factors (2015)
Journal Article

Liver biopsy is the standard test for the assessment of fibrosis in liver tissue of patients with chronic liver disease. Recent studies have used a non‐invasive measure of T1 relaxation time to estimate the degree of fibrosis in a single slice of the... Read More about A study of T1 relaxation time as a measure of liver fibrosis and the influence of confounding histological factors.

Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men (2015)
Journal Article

The ability to maintain skeletal muscle mass appears to be impaired in insulin-resistant conditions, such as type 2 diabetes, that are characterized by muscle lipid accumulation. The current study investigated the effect of acutely increasing lipid a... Read More about Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men.

Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology: Vascular impairments in HD (2015)
Journal Article

Objective Although the underlying cause of Huntington's disease (HD) is well established, the actual pathophysiological processes involved remain to be fully elucidated. In other proteinopathies such as Alzheimer's and Parkinson's diseases, there... Read More about Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology: Vascular impairments in HD.

Hemispheric asymmetry in cerebrovascular reactivity of the human primary motor cortex: an in vivo study at 7 T (2015)
Journal Article

Current functional MRI (fMRI) approaches assess underlying neuronal activity through monitoring the related local variations in cerebral blood oxygenation, blood volume and blood flow. This vascular response is likely to vary across brain regions and... Read More about Hemispheric asymmetry in cerebrovascular reactivity of the human primary motor cortex: an in vivo study at 7 T.

7 Tesla fMRI reveals systematic functional organization for binocular disparity in dorsal visual cortex (2015)
Journal Article

© 2015 the authors. The binocular disparity between the views of the world registered by the left and right eyes provides a powerful signal about the depth structure of the environment. Despite increasing knowledge of the cortical areas that process... Read More about 7 Tesla fMRI reveals systematic functional organization for binocular disparity in dorsal visual cortex.

The effect of isocapnic hyperoxia on neurophysiology as measured with MRI and MEG (2015)
Journal Article

The physiological effect of hyperoxia has been poorly characterised, with studies reporting conflicting results on the role of hyperoxia as a vasoconstrictor. It is not clear whether hyperoxia is the primary contributor to vasoconstriction or whether... Read More about The effect of isocapnic hyperoxia on neurophysiology as measured with MRI and MEG.

Assessing the spatial precision of SE and GE-BOLD contrast at 7 Tesla (2014)
Journal Article

Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation (2014)
Journal Article

Acylcarnitine accumulation in skeletal muscle and plasma has been observed in numerous models of mitochondrial lipid overload and insulin resistance. Fish oil n3PUFA (omega-3 polyunsaturated fatty acids) are thought to protect against lipid-induced i... Read More about Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation.