All Outputs (8)

In silico evaluation and optimisation of magnetic resonance elastography of the liver (2021)
Journal Article
McGrath, D. M., Bradley, C. R., & Francis, S. T. (2021). In silico evaluation and optimisation of magnetic resonance elastography of the liver. Physics in Medicine and Biology, 66(22), Article 225005. https://doi.org/10.1088/1361-6560/ac3263

Objective. Magnetic resonance elastography (MRE) is widely adopted as a biomarker of liver fibrosis. However, in vivo MRE accuracy is difficult to assess. Approach. Finite element model (FEM) simulation was employed to evaluate liver MRE accuracy and... Read More about In silico evaluation and optimisation of magnetic resonance elastography of the liver.

Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies (2021)
Journal Article
McGing, J. J., Radford, S. J., Francis, S. T., Serres, S., Greenhaff, P. L., & Moran, G. W. (2021). Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies. Alimentary Pharmacology and Therapeutics, 54(4), 368-387. https://doi.org/10.1111/apt.16465

Background: Fatigue is the inability to achieve or maintain an expected work output resulting from central or peripheral mechanisms. The prevalence of inflammatory bowel disease (IBD) fatigue can reach 86% in active disease, persisting in 50%-52% of... Read More about Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies.

Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males (2021)
Journal Article
Quinlan, J. I., Franchi, M. V., Gharahdaghi, N., Badiali, F., Francis, S., Hale, A., …Narici, M. V. (2021). Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males. GeroScience, 43(4), 1567-1584. https://doi.org/10.1007/s11357-021-00396-0

Resistance exercise training (RET) is well-known to counteract negative age-related changes in both muscle and tendon tissue. Traditional RET consists of both concentric (CON) and eccentric (ECC) contractions; nevertheless, isolated ECC contractions... Read More about Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males.

Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: comparison in younger and older adults (2021)
Journal Article
Burley, C. V., Francis, S. T., Whittaker, A. C., Mullinger, K. J., & Lucas, S. J. E. (2021). Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: comparison in younger and older adults. Brain and Behavior, 11(7), Article e02126. https://doi.org/10.1002/brb3.2126

Introduction: Resting cerebral blood flow (CBF) and perfusion measures have been used to determine brain health. Studies showing variation in resting CBF with age and fitness level using different imaging approaches have produced mixed findings. We a... Read More about Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: comparison in younger and older adults.

Contrasting Measures of Cerebrovascular Reactivity Between MRI and Doppler: A Cross-Sectional Study of Younger and Older Healthy Individuals (2021)
Journal Article
Burley, C. V., Francis, S. T., Thomas, K. N., Whittaker, A. C., Lucas, S. J., & Mullinger, K. J. (2021). Contrasting Measures of Cerebrovascular Reactivity Between MRI and Doppler: A Cross-Sectional Study of Younger and Older Healthy Individuals. Frontiers in Physiology, 12, Article 656746. https://doi.org/10.3389/fphys.2021.656746

Cerebrovascular reactivity (CVR) is used as an outcome measure of brain health. Traditionally, lower CVR is associated with ageing, poor fitness and brain-related conditions (e.g. stroke, dementia). Indeed, CVR is suggested as a biomarker for disease... Read More about Contrasting Measures of Cerebrovascular Reactivity Between MRI and Doppler: A Cross-Sectional Study of Younger and Older Healthy Individuals.

Quantitative T1 mapping using multi-slice multi-shot inversion recovery EPI (2021)
Journal Article
Sanchez Panchuelo, R. M., Mougin, O., Turner, R., & Francis, S. T. (2021). Quantitative T1 mapping using multi-slice multi-shot inversion recovery EPI. NeuroImage, 234, Article 117976. https://doi.org/10.1016/j.neuroimage.2021.117976

An efficient multi-slice inversion–recovery EPI (MS-IR-EPI) sequence for fast, high spatial resolution, quantitative T1 mapping is presented, using a segmented simultaneous multi-slice acquisition, combined with slice order shifting across multiple a... Read More about Quantitative T1 mapping using multi-slice multi-shot inversion recovery EPI.

Automated renal segmentation in healthy and chronic kidney disease subjects using a convolutional neural network (2021)
Journal Article
Daniel, A., Buchanan, C., Allcock, T., Scerri, D., Cox, E., Prestwich, B., & Francis, S. (2021). Automated renal segmentation in healthy and chronic kidney disease subjects using a convolutional neural network. Magnetic Resonance in Medicine, 86(2), 1125-1136. https://doi.org/10.1002/mrm.28768

Purpose: Total Kidney Volume (TKV) is an important measure in renal disease detection and monitoring. We developed a fully automated method to segment the kidneys from T2-weighted magnetic resonance images (MRI) to calculate TKV of healthy control (H... Read More about Automated renal segmentation in healthy and chronic kidney disease subjects using a convolutional neural network.

Multiparametric MRI assessment of renal structure and function in acute kidney injury and renal recovery (2021)
Journal Article
Buchanan, C., Mahmoud, H., Cox, E., Noble, R., Prestwich, B., Kasmi, I., …Selby, N. M. (2021). Multiparametric MRI assessment of renal structure and function in acute kidney injury and renal recovery. Clinical Kidney Journal, 14(8), 1969-1976. https://doi.org/10.1093/ckj/sfaa221

Background: Acute Kidney Injury (AKI) is associated with a marked increase in mortality as well as subsequent chronic kidney disease (CKD) and end stage kidney disease. We performed multiparametric MRI with the aim of identifying potential non-invasi... Read More about Multiparametric MRI assessment of renal structure and function in acute kidney injury and renal recovery.