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Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: comparison in younger and older adults

Burley, Claire V; Francis, Susan T; Whittaker, Anna C; Mullinger, Karen J; Lucas, Samuel J E

Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: comparison in younger and older adults Thumbnail


Authors

Claire V Burley

Anna C Whittaker

Samuel J E Lucas



Abstract

Introduction: Resting cerebral blood flow (CBF) and perfusion measures have been used to determine brain health. Studies showing variation in resting CBF with age and fitness level using different imaging approaches have produced mixed findings. We assess the degree to which resting CBF measures through transcranial Doppler (TCD) and arterial spin labelling (ASL) MRI provide complementary information in older and younger, fit and unfit cohorts. Methods: Thirty-five healthy volunteers (20 younger: 24±7y; 15 older: 66±7y) completed two experimental sessions (TCD/MRI). Aging and fitness effects within and between imaging modalities were assessed. Results: Middle cerebral artery blood velocity (MCAv, TCD) was lower and transit time (MRI) slower in older compared with younger participants (p

Citation

Burley, C. V., Francis, S. T., Whittaker, A. C., Mullinger, K. J., & Lucas, S. J. E. (2021). Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: comparison in younger and older adults. Brain and Behavior, 11(7), Article e02126. https://doi.org/10.1002/brb3.2126

Journal Article Type Article
Acceptance Date Mar 10, 2021
Online Publication Date May 25, 2021
Publication Date 2021-07
Deposit Date Mar 17, 2021
Publicly Available Date May 25, 2021
Journal Brain and Behavior
Print ISSN 2162-3279
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 11
Issue 7
Article Number e02126
DOI https://doi.org/10.1002/brb3.2126
Keywords Aging, cerebral haemodynamics, MRI functional, multimodal imaging, cerebral blood flow, transcranial Doppler sonography
Public URL https://nottingham-repository.worktribe.com/output/5399914
Publisher URL https://onlinelibrary.wiley.com/doi/10.1002/brb3.2126

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