Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: comparison in younger and older adults

Burley, Claire V; Francis, Susan T; Whittaker, Anna C; Mullinger, Karen J; Lucas, Samuel J E

Abstract

Introduction: Resting cerebral blood flow (CBF) and perfusion measures have been used to determine brain health. Studies showing variation in resting CBF with age and fitness level using different imaging approaches have produced mixed findings. We assess the degree to which resting CBF measures through transcranial Doppler (TCD) and arterial spin labelling (ASL) MRI provide complementary information in older and younger, fit and unfit cohorts. Methods: Thirty-five healthy volunteers (20 younger: 24±7y; 15 older: 66±7y) completed two experimental sessions (TCD/MRI). Aging and fitness effects within and between imaging modalities were assessed. Results: Middle cerebral artery blood velocity (MCAv, TCD) was lower and transit time (MRI) slower in older compared with younger participants (p

Citation

Burley, C. V., Francis, S. T., Whittaker, A. C., Mullinger, K. J., & Lucas, S. J. E. (2021). Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: comparison in younger and older adults. Brain and Behavior, 11(7), Article e02126. https://doi.org/10.1002/brb3.2126

• Journal Article Type: Article
• Acceptance Date: Mar 10, 2021
• Online Publication Date: May 25, 2021
• Publication Date: 2021-07
• Deposit Date: Mar 17, 2021
• Publicly Available Date: May 25, 2021
• Journal: Brain and Behavior
• Print ISSN: 2162-3279
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 7
• Article Number: e02126
• DOI: https://doi.org/10.1002/brb3.2126
• Keywords: Aging, cerebral haemodynamics, MRI functional, multimodal imaging, cerebral blood flow, transcranial Doppler sonography
• Public URL: https://nottingham-repository.worktribe.com/output/5399914
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1002/brb3.2126