Claire V Burley
Contrasting Measures of Cerebrovascular Reactivity Between MRI and Doppler: A Cross-Sectional Study of Younger and Older Healthy Individuals
Burley, Claire V; Francis, Susan T.; Thomas, Kate N; Whittaker, Anna C; Lucas, Samuel JE; Mullinger, Karen J.
Authors
Professor SUSAN FRANCIS susan.francis@nottingham.ac.uk
Professor of Physics
Kate N Thomas
Anna C Whittaker
Samuel JE Lucas
Dr KAREN MULLINGER KAREN.MULLINGER@NOTTINGHAM.AC.UK
Associate Professor
Abstract
Cerebrovascular reactivity (CVR) is used as an outcome measure of brain health. Traditionally, lower CVR is associated with ageing, poor fitness and brain-related conditions (e.g. stroke, dementia). Indeed, CVR is suggested as a biomarker for disease risk. However, recent findings report conflicting associations between ageing or fitness and CVR measures. Inconsistent findings may relate to different neuroimaging modalities used, which include transcranial Doppler (TCD) and blood-oxygen-level-dependant (BOLD) contrast magnetic resonance imaging (MRI). We assessed the relationship between CVR metrics derived from two common imaging modalities, TCD and BOLD MRI, within the same individuals and with expected significant differences (i.e. younger vs. older) to maximise the expected spread in measures. We conducted two serial studies using TCD- and MRI-derived measures of CVR (via inspired 5% CO2 in air). Study 1 compared 20 younger (24±7 years) with 15 older (66±7 years) participants, Study 2 compared 10 younger (22±2 years) with 10 older (72±4 years) participants. Combining the main measures across studies, no significant correlation (r=0.15, p=0.36) was observed between individual participant TCD- and BOLD-CVR measures. Further, these measures showed differential effects between age groups; with TCD-CVR higher in the older compared to younger group (4±1 vs. 3±1 %MCAv/mmHg PETCO2; p0.05, Hedges’ g=1.08). The PCA CVR metrics did not significantly correlate with the BOLD- or TCD-CVR measures. The differing CVR observations between imaging modalities were despite expected, correlated (r=0.62-0.82), age-related differences in resting CBF measures across modalities. Taken together, findings across both studies show no clear relationship between TCD- and BOLD-CVR measures. We hypothesize that CVR differences between imaging modalities are in part due to the aspects of the vascular tree that are assessed (TCD:arteries; BOLD:venules/veins). Further work is needed to understand the between-modality CVR response differences, but caution is needed when comparing CVR metrics derived from different imaging modalities.
Citation
Burley, C. V., Francis, S. T., Thomas, K. N., Whittaker, A. C., Lucas, S. J., & Mullinger, K. J. (2021). Contrasting Measures of Cerebrovascular Reactivity Between MRI and Doppler: A Cross-Sectional Study of Younger and Older Healthy Individuals. Frontiers in Physiology, 12, Article 656746. https://doi.org/10.3389/fphys.2021.656746
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 10, 2021 |
Online Publication Date | Apr 12, 2021 |
Publication Date | Apr 12, 2021 |
Deposit Date | Mar 17, 2021 |
Publicly Available Date | Apr 12, 2021 |
Journal | Frontiers in Physiology |
Publisher | Frontiers Media |
Peer Reviewed | Peer Reviewed |
Volume | 12 |
Article Number | 656746 |
DOI | https://doi.org/10.3389/fphys.2021.656746 |
Keywords | Cerebrovascular reactivity; transcranial Doppler; magnetic resonance imaging |
Public URL | https://nottingham-repository.worktribe.com/output/5399217 |
Publisher URL | https://www.frontiersin.org/articles/10.3389/fphys.2021.656746/full |
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