Community guidelines for GPCR ligand bias: IUPHAR review 32

Kolb, Peter; Kenakin, Terry; Alexander, Stephen P. H.; Bermudez, Marcel; Bohn, Laura M.; Breinholt, Christian S.; Bouvier, Michel; Hill, Stephen J.; Kostenis, Evi; Martemyanov, Kirill; Neubig, Rick R.; Onaran, H. Ongun; Rajagopal, Sudarshan; Roth, Bryan L.; Selent, Jana; Shukla, Arun K.; Sommer, Martha E.; Gloriam, David E.

doi:10.1111/bph.15811

All Outputs (5)

Development of a novel cell-based, In-Cell Western/ERK assay system for the high-throughput screening of agonists acting on the delta-opioid receptor (2022)
Journal Article

Background: Extracellular signal-regulated kinases (ERKs) are important signaling mediators in mammalian cells and, as a result, one of the major areas of research focus. The detection and quantification of ERK phosphorylation as an index of activati... Read More about Development of a novel cell-based, In-Cell Western/ERK assay system for the high-throughput screening of agonists acting on the delta-opioid receptor.

Environmental pharmacology—Dosing the environment: IUPHAR review 36 (2022)
Journal Article

Pesticide action is predominantly measured as a toxicological outcome, with pharmacological impact of sublethal doses on bystander species left largely undocumented. Likewise, chronic exposure, which often results in responses different from acute ad... Read More about Environmental pharmacology—Dosing the environment: IUPHAR review 36.

Perspective article: A proposal for rational drug class terminology (2022)
Journal Article

Collective names for drugs were coined for various reasons, some of which we would now recognise as misguided.

Planning experiments: Updated guidance on experimental design and analysis and their reporting III (2022)
Journal Article

Scientists who plan to publish in British Journal of Pharmacology (BJP) must read this article before undertaking a study. This editorial provides guidance for the design of experiments. We have published previously two guidance documents on experime... Read More about Planning experiments: Updated guidance on experimental design and analysis and their reporting III.

Community guidelines for GPCR ligand bias: IUPHAR review 32 (2022)
Journal Article

GPCRs modulate a plethora of physiological processes and mediate the effects of one-third of FDA-approved drugs. Depending on which ligand activates a receptor, it can engage different intracellular transducers. This ‘biased signalling’ paradigm requ... Read More about Community guidelines for GPCR ligand bias: IUPHAR review 32.